2006 Fiscal Year Final Research Report Summary
Disease risk and preventive medical evaluation of gene polymorphism in relation to hyperlipidemia and diabetes mellutus
Project/Area Number |
17590509
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Chiba University |
Principal Investigator |
SUWAZONO Yasushi Chiba University, Graduate School of Medicine, Associate Professor, 大学院医学研究院, 助教授 (90302546)
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Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Etsuko Chiba University, Graduate School of Medicine, Lecturer, 大学院医学研究院, 講師 (80097427)
DOCHI Mirei Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手 (30376371)
NOGAWA Koji Chiba University, Graduate School of Medicine, Professor, 大学院医学研究院, 教授 (40019584)
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Project Period (FY) |
2005 – 2006
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Keywords | Genetic polymorphism / Hyperlipidemia / Diabetes mellitus |
Research Abstract |
We examined the relationship between the A1330V and Q89R variants in the low-density lipoprotein receptor-related protein 5 (LRP5) gene, and the risk of hypercholesterolemia in a prospective study in Japanese workers. This study included observations over a 5-year period from 1997 to 2002 on 956 males and 662 females who were not hypercholesterolemic on entry. Hypercholesterolemia was defined as a serum total cholesterol level ≧240 mg/dL. Pooled logistic regression analyses were performed using either of the gene variants with age, body mass index, smoking, alcohol consumption and habitual exercise as the covariates. The risk of the development of hypercholesterolemia was 1.49 times higher in males with the AV genotype of LRP5/A1330V than in males with the AA genotype (95% confidence interval : 1.04-2.12) after adjustment for the effects of other potential covariates. Furthermore, the C1429T of G-protein beta 3 subunit variant was an independent significant risk factors for hypercholesterolemia as well. Therefore, pooled logistic regression analyses were performed again to examine the association between the combination of polymorphisms and hypercholesterolemia using age, body mass index, smoking, alcohol consumption and habitual exercise as covariates that had potential to affect cholesterol levels. The odd ratios in males and females with GNB3/1429TT and LRP5/1330VV or AV genotypes were 4.17 compared to males with the 1429CT or TT and 1330AA genotypes and 3.53 compared to females with the 1429CC, CT or TT and 1330AA genotypes. This study indicates that the combination of GNB3/C1429T and LRP5/A1330V is a very useful marker for predicting the development of hypercholesterolemia in the general Japanese population.
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