2006 Fiscal Year Final Research Report Summary
Study on the Metabolic Syndrome in Japanese Living in Japan and Hawaii for Prevention of Atherosclerotic Disease.
| Project/Area Number |
17590563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
NAKAMURA Yasuyuki Kyoto Women's University, Home Economics, Professor, 家政学部, 教授 (20144371)
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| Co-Investigator(Kenkyū-buntansha) |
UESHIMA Hirotsugu Shiga Univ. of Medical Science, Health Sci, Professor, 医学部, 教授 (70144483)
OKAMURA Tomonori Shiga Univ. of Med. Sci., Health Sci, Assoc Professor, 医学部, 助教授 (00324567)
KITA Yoshikuni Shiga Univ. of Med. Sci., Health Sci, Assist. Professor, 医学部, 助手 (80161462)
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| Project Period (FY) |
2005 – 2006
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| Keywords | The Metabolic Syndrome / Adiponectin / Japanese American in Hawaii / Obesity / Community-based Population / Epidemiology |
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| Research Abstract |
Backgrounds : A novel adipose-specific protein, adiponectin has been suggested to play an important role in modulation of the metabolic syndrome (MetSx). We compared the prevalence of MetSx and the plasma adiponectin concentrations among Japanese men and women in Japan and Hawaii.
Methods : In between 1997 and 1998, community-based men and women aged 40-59 years were examined by common standardized methods-a sample in Japan (130 men and 129 women) and a Japanese-American sample in Hawaii (136 men and 131 women).
MetSx was defined as the co-occurrence of any 3 or more of the following 5 abnormalities: body mass index (BMI) > 30 kg/m2, HbA1c > 5.6%, blood pressure 130/85 mmHg or use of antihypertensive therapy, triglycerides greater than or equal 150 mg/dl, HDLc < 40 mg/dl.
Results : The mean BMI was higher in those who live in Hawaii than those in Japan (men: 23.4±2.8 vs 28.1±4.7 kg/m2, P<0.0001; women: 23.4±3.0 vs 25.9±5.4 kg/m2, P<0.0001). The prevalence of MetSx was higher in those who live in Hawaii than those in Japan (men: 3.9% vs 23.2%, P<0.0001; women: 2.3% vs 9.7%, P=0.012)
The mean adiponectin was higher in those who live in Japan (men: 8.1±3.8 vs 6.7±3.2 μg/ml, P=0.003; women 12.9±6.1 vs 9.3±4.2 μg/ml, P<0.0001), however, the difference was not significant among those with BMI > 28 kg/m2 (P=0.16 for men and P=0.40 for women). Significant determinants of adiponectin were BMI, HDLc and Alcohol consumption in men, and Age, BMI, Site, HDLc, and Energy intake in women.
Conclusions : BMI has a significant effect on MetSx and adiponectin in Japanese.
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Research Products
(6 results)
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[Journal Article] Higher level of adiponectin in America than in Japanese men despite obesity2006
Author(s)
Kadowaki A, Sekikawa A, Okamura T, Takamiya T, Kashiwagi A, Zaky Q, Maegawa H, El-Saed A, Nakamura Y, Evans RW, Edmundowicz, Kita Y, Kuller L, Ueshima H.
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Journal Title
Metabolism 55
Pages: 1561-1563
Description
「研究成果報告書概要(欧文)」より
