2007 Fiscal Year Final Research Report Summary
Development of physiological or biochemical predictors of cognitive decline among community - dwelling older adults
| Project/Area Number |
17590568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
FUJIWARA Yoshinori Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropoli, Sub-leader (50332367)
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| Co-Investigator(Kenkyū-buntansha) |
SHINKAI Shouji Tokyo Metropolitan Foundation for Resaeach on Agings, and Promition of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Leader (60171063)
AMANO Hidenori Tokyo Metropolitan Foundation for Resaeach on Agings, and Promition of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Research Assistant (90260306)
UCHIDA Hayato University of Hyogo, School of Human Science and Environment, Associate Professor (50213442)
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| Project Period (FY) |
2005 – 2007
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| Keywords | cognitive decline / screening / physiological marker / biochemical marker / prevention of disability |
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| Research Abstract |
Objective: To Develop physiological or biochemical predictors for cognitive decline among community-dwelling older adults
Methods: The study population included 382 community-dwelling Japanese person ages 70 years and older who participated in a comprehensive health examination June 2004. In addition to conventional medical examination such as blood pressure and routine blood analyses, cognitive function was tested using the Mini-Mental State Examinations (MMSE) and phonological and semantic verbal fluency tests. Also, we examined brachial-ankle pulse wave velocity (baPWV) which is an independent predictor of cardiovascular diseases and serum β_2-microglobulin (β_2-M) which is an independent predictor of total mortality. Results: Poor cognitive function (MMSE<24; phonological verbal fluency test<12 words) was independently associated with the middle tertile of baPWV (1750-2070 cm/sec) by cross-sectional analysis (odds ratio =9.66, 95% confidence interval = 1.15 to 80.93; odds ratio =1.73, 95% confidence interval = 1.10 to 2.74, respectively) but was not significant by 3-year follow-up. On the other hand, high concentration of β_2-M (≧1.5 mg/dL) was an independent predictor of poor phonological verbal fluency (odds ratio =2.09, 95% confidence interval = 1.04 to 4.21).
Conclusion: higher β_2-M might contribute to the subsequent poor phonological verbal fluency.
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