2007 Fiscal Year Final Research Report Summary
The association offunctional gene polymorphisms with tbe progression of liver fibrosis in chronic hepatitis C.
| Project/Area Number |
17590641
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tottori University |
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Principal Investigator |
MURAWAKI Yoshikazu Tottori University, Faculty of Medicine, Professor (90144659)
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| Project Period (FY) |
2005 – 2007
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| Keywords | chronic hepatitis / liver fibrosis / genotype / MMP-1 / MMP-3 / MMP-9 / TGF-β1 / IL-1β |
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| Research Abstract |
In chronic hepatitis C, the interindividual difference in responses against the hepatic necroinflammation appears to be important in the progression of liver fibrosis. This study was to examine the possible association of MMP-1 -1607 1G/2G, MMP-2. -1306 C/T, MMP-3 -1171 5A/6A, MMP-7 -181 A/G, MMP-9 -1562 T/C, TGF-βl +819 T/C, IL-lβ -511 C/T, IL-1RN VNTR polymorphisms with the progression of liver fibrosis in Japanese patients with hepatitis C virus-related chronic liver disease, using cross-sectional and longitudinal study designs. We examined 93 chronic hepatitis C patients and 90 liver cirrhosis C patients. The chronic hepatitis patients were divided into progressive fibrosis and non-progressive fibrosis groups. Gene lymorphisms were analyzed using a polymerase-chain reaction-based assay. In the cross-sectional study, the MMP-1 2G/2G homozygotes and MMP-9 C/C homozygotes were significantly more in cirrhosis group than in chronic hepatitis group, whereas other genotypes showed no significant differences. In the longitudinal study, MMP-3 5A carriers and TGF-β1 T carriers were significantly more in the progressive fibrosis group than in non-progressive fibrosis group, whereas other genotypes showed no significant differences. These findings suggest that MMP-1, MMP-3, MMP-9 and TGF-131 genotypes account for some of the variability in the progression of chronic hepatitis C.
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[Journal Article] Association of functional gene polymorphisms of interleukin-I f and transforming growth factor -β1 with the progression of liver fibrosis in Japanese patients with hepatitis C virus-related chronic liver disease2007
Author(s)
Mandai, M., Murawaki, Y., Okamoto, K., Ohtani, H., Maeda, N., Yuasa, I
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Journal Title
Yonago Acta med 50
Pages: 89-97
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genetic polymorphismsof matrix metalloproteinases and interleukin-β with the progression of liver fibrosis in chronic hepatitis C.2006
Author(s)
Mandai, M., Okamoto, K., Mimura, K., Ootani, H., Maeda, N., Murawaki, Y
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Journal Title
Jpn Pharmacol Ther 34
Pages: S171-S174
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The association of MMP-1, -3 and -9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients2005
Author(s)
Okamoto, K., Mandai, M., Mimura, K., Murawaki, Y., Yuasa, I
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Journal Title
Res Commun Mol pathol Pharmacol 117-118
Pages: 77-89
Description
「研究成果報告書概要(欧文)」より
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