2006 Fiscal Year Final Research Report Summary
Proteomic analysis of liver cells infected with hepatitis C virus
| Project/Area Number |
17590647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAKI Akinobu Okayama University, University Hospital of Medicine And Dentistry, Assistant, 医学部・歯学部附属病院, 助手 (80359885)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Jun Okayama University, University Hospital of Medicine And Dentistry, Assistant, 医学部・歯学部附属病院, 助手 (90379743)
IWASAKI Yoshiaki Okayama University, University Hospital of Medicine And Dentistry, Assistant, 医学部・歯学部附属病院, 助手 (00314667)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Hepatocellular carcinoma / Proteome analysis |
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| Research Abstract |
Chronic infection of hepatitis C virus (HCV) is closely related with hepatocarcinogenesis. Although considerable progress has been made during recent years, the mechanism of carcinogenesis is still in discussion. We have employed proteomic techniques in an HCV replicon cell, to elucidate the mechanism of hepatocarcinogenesis in HCV infected patients. By comparing the protein expression profiles of HCV subgenomic replicon cell line and its cured cell, we obtained several proteins that were positively expressed in replicon cells. There were several proteins that could be associated with cell proliferation and apoptosis control including UCH-L1, TCP-1, RALDH1, and Elongation factor 2. Such an analysis of protein expression profile in HCV replication cells will extend our understanding of the mechanism of HCV hepatocarcinogenesis.
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