Clinical Impact of Dysadherin Expression in tissue of Pancreatic Cancer obtained by biopsy and resection.

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17590665
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: KUBOTA Kensuke Yokohama City University, Hospital, Associate professor, 附属病院内視鏡室, 準教授 (70381499)
• Co-Investigator(Kenkyū-buntansha): ATSUSHI Nakajima Yokohama City University, School of medicine, Associate professor, 医学研究科, 準教授 (30326037) ; KIRIKOSHI Hiroyuki Yokohama City University, Hospital, Assistant Professor, 附属病院, 助手 (80347294)
• Project Period (FY): 2005 – 2006
• Keywords: Pancreatic cancer / Dysadherin / Early diagnosis

Research Abstract

In this study, we tried to investigate the clinicalpathological impact of dysadherin expression by using tissue obtained biopsy and resection from patients with pancreatic cancer, which could be an early marker for human pancreatic cancer. T Shimamura elucidated the cell motility and metastatic potential of dysadherin expression in the human pancreatic cancer cells (T Shimamura et al. Dysadherin expression facilitate cell motility and metastatic potential of human pancreatic cancer cells. Cancer Research 2004;64:6989-6995).
Although, we studied this new marker in pancreatic juice contained cancer cells obtained while ERCP compared with patients of chronic pancreatitis and with autoimmune pancreatitis in 2007, it was difficult to obtain pancreatic cancer cells using endfoscopic procedure. We could' t get any useful and rewarding result.
In 2008, we modified our method to take pancreatic tissue by using FNA and endoscopic biopsy from duodenal papilla. As a result, we found that the positivity rate of dysadherin is significantly higher in pancreatic tissue and tissue of duodenal papilla than that from patients with chronic pancreatitis. We conclude that the detection of dysadherin expression in human advanced pancreatic cancer in the resected tissues and biopsied specimens is useful marker.

Research Products

• [Journal Article] Type IV collagen 7s domain is independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage. (2007)
  • Author(s): M Yoneda, H Mawatari, K Fujuta, Kyoko Yonemitu, S Kato, H Takahashi, S Saito, H Kirikoshi, M Inamori, Y Nozaki, Y Abe, K Kubota, S Saito, T Iwasaki, Y Terauti, S Togo, A Nakajima
  • Journal Title: J Gastroenterology 42 Pages: 375-381
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Type IV collagen 7s domain is independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage. (2007)
  • Author(s): M Yoneda, H Mawatari, K Fujuta, Kyoko Yonemitu, S Kato, H Takahashi, S Saito, H Kirikoshi, M Inamori, Y Nozaki, Y Abe, K Kubota, S Saito, T Iwasaki, Y Terauti, S Togo, A Nakajima
  • Journal Title: J Gastroenterol. 42 Pages: 375-381
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical Significance of Swollen Duodenal Papilla in Autoimmune Pancreatitis
  • Author(s): Kensuke Kubota, Hiroshi Iida, Toshio Fujisawa, Masami Ogawa, Masahiko Inamori, Satoru Saito, Yukio Kakuta, Hisashi Oshiro, Atushi Nakajima
  • Journal Title: Pancreas (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinicopathological study of resected cases with primary carcinoma of thecystic duct.
  • Author(s): Kensuke Kubota, Yukio Kakuta, Yoshiaki Inayama, Masato Yoneda, Yasunobu Abe, Masahiko Inamori, Hiroyuki Kirikoshi, Satoru Saito, Atushi Nakajima, Kazuya Sugimori, Kenichi Matuo, Takeda Kazunaga, Hiroshi Shimada
  • Journal Title: Hepato-Gastroenterology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary-Mucinous Neoplasms.
  • Author(s): Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshi H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A
  • Journal Title: J Hepatobiliary Pancreat Surg. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical Significance of Swollen Duodenal Papilla in Autoimmune Pancreatitis
  • Author(s): Kensuke Kubota, Hiroshi Iida, Toshio Fujisawa, Masami Ogawa, Masahiko Inamori, Satoru Saito, Yukio Kakuta, Hisashi Oshiro, Atushi Nakajima
  • Journal Title: Pancreas. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinicopathological study of resected cases with primary carcinoma of thecystic duct.
  • Author(s): Kensuke Kubota, Yukio Kakuta, Yoshiaki Inayama, Masato Yoneda, Yasunobu Abe, Masahiko Inamori, Hiroyuki Kirikoshi, Satoru Saito, Atushi Nakajima, Kazuya Sugimori, Kenichi Matuo, Takeda Kazunaga, Hiroshi Shimada
  • Journal Title: Hepato-Gastroenterology. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary-Mucinous Neoplasms.
  • Author(s): Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshi H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A.
  • Journal Title: J Hepatobiliary Pancreat Surg. (in press)
  • Description: 「研究成果報告書概要(欧文)」より