2006 Fiscal Year Final Research Report Summary
Basic Research for Regeneration Therapy for Liver Failure
| Project/Area Number |
17590682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
AZUMA Toshifumi Tokyo Dental College, Dept.Dental Medicine, Ass.Prof, 歯学部, 助教授 (00222612)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Jiro Tokyo Dental College, Dept.Medicine, Prof, 歯学部, 教授 (50198470)
WAKABAYASHI Go Iwate University, Dept.of Medicine, Prof, 医学部, 教授 (50175064)
OKANO Hideyuki Keio university, Dept.of Medicine, Prof, 医学部, 教授 (60160694)
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| Project Period (FY) |
2005 – 2006
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| Keywords | SP cell / Stem Cell / Stem cell transplantation / liver Failure / Liver cirrhosis / Hepatocyte transplantation / Primary hepatocyte culture / Spleen |
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| Research Abstract |
Self-renewal is one of the primary functions of stem cells, assisting in tissue repair and maintenance. However, its precise mechanism has yet to be determined. We found that liver injury caused a remarkable increase in the frequencies of side population (SP) cells in mouse and human spleen. On the other hand, other splenomegaly-causing diseases elicited no increase in splenic SP frequency. We found that liver damage induced expression of TGF-β in spleen, which inhibited Fas-mediated apoptosis of splenic SP cells by down-regulating Fas expression. This mechanism may account for increased splenic SP frequency in liver injury. If so, apoptosis may play an important role in the regulation of self-renewal in SP cells.
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