2006 Fiscal Year Final Research Report Summary
Assessment and Evaluation of Vascular Vulnerability in Patients with Atherosclerosis: Clinical Examination and Application
| Project/Area Number |
17590753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University, Kumamoto University Hospital |
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Principal Investigator |
SUGIYAMA Seigo Kumamoto University, Kumamoto University Hospital, Lecturer, 医学部附属病院, 講師 (90274711)
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| Project Period (FY) |
2005 – 2006
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| Keywords | athero sclerosis / ultrasound / plaque stabilization / lipid lowering / statin / cholesterol / endothelial cells / diabetes |
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| Research Abstract |
OBJECTIV ES: Atherosclerotic plaque stabilization is a promising clinical strategy to prevent cardiovascular events in patients with coronary artery disease (CAD). There is a correlation between coronary and carotid plaque instability, and echolucent plaques are recognized as vulnerable plaques. We examined whether intensive cholesterol-lowering therapy with statins in nonhypercholesterolemic patients is effective in improving echolucency of vulnerable plaques assessed by ultrasound with integrated backscatter (IBS) analysis.We also examine whether CD144-EMP (endothelium derived microparticles) is useful as a specific marker of endothelial cell (EC) dysfunction and to determine whether plasma levels of circulating CD144-EMP predicted CAD in patients with type 2 diabetes mellitus (DM).
RESULTS : Total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-sensitivity C-reactive protein were significantly decreased in the statin group. Significant increases of echogenicity of
… More
carotid plaques were noted in the statin grcup but not in the diet group without significant regression of plaque-IMT values in both groups. We demonstrated that CD144-positive microparticles were derived selectively from human EC. The levels of CD144-EMP reflected the degree of in vitro hydrogen-peroxide-induced EC injury and impairment of in vivo endothelium-dependent coronary vasodilation. Plasma CD144-EMP levels were increased significantly in DM patients compared with patients without DM. In DM patients, the elevated levels of CD144-EMP were the most significant risk factor for CAD relative to all other traditional risk factors.
CONCLUSIONS: Statin therapy is rapidly effective in increasing echogenicity of vulnerable plaques without regression of plaque size in nonhypercholesterolemic patients with CAD. Quantitative assessment of carotid plaque quality by ultrasound with IBS is clinically useful for monitoring atherosclerotic lesions by evaluating vulnerability of atheroma. The CD144-positive EMP exist in human plasma, and plasma CD144-EMP levels can be a clinically specific and quantitative marker of EC dysfunction and/or injury. Measurement of CD144-EMP, by providing a quantitative assessment of EC dysfunction, may be useful for identifying DM patients with increased risk of CAD. Less
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Research Products
(15 results)
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[Journal Article] Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease2006
Author(s)
Koga, H., Sugiyama, S., Kugiyama, K., Fukushima, H., Watanabe, K., Sakamoto, T., Yoshimura, M., Jinnouchi, H., Ogawa, H.
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Journal Title
Eur Heart J 27
Pages: 817-823
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease2006
Author(s)
Otsuka, F., Sugivama, S., Kojima, S., Maruyoshi, H., Funahashi, T., Matsui, K., Sakamoto, T., Yoshimura, M., Kimura, K., Umemura, S., Ogawa, H.
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Journal Title
J Am Coll Cardiol 48
Pages: 1155-1162
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Characterization of smooth muscle-like cells in circulating human peripheral blood2006
Author(s)
Sugiyama, S., Kugiyama, K., Nakamura, S., Kataoka, K., Aikawa, M., Shimizu, K., Koide, S., Mitchell, R.N., Ogawa, H., Libby, P.
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Journal Title
Atherosclerosis 187
Pages: 351-362
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fulminant myocarditis survivor after 56 hours of non-responsive cardiac arrest successfully returned to normal life by cardiac resynchronization therapy : a case report2006
Author(s)
Sugamura, K., Sugivama, S., Kawano, H., Horio, E., Ono, S., Kojima, S., Kaikita, K., Sagishima, K., Sakamoto, T., Yoshimura, M., Kinoshita, Y., Ogawa, H.
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Journal Title
J Cardiol 48
Pages: 345-352
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Floating coronary artery thrombus prior to the onset of acute myocardial infarction2006
Author(s)
Maruyoshi, H., Sugiyama, S., Araki, S., Kojima, S., Hayasaki, T., Kaikita, K., Fukushima, S., Kageshita, T., Sakamoto, T., Yoshimura, M., Ono, T., Ogawa, H.
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Journal Title
Intern Med 45
Pages: 173-174
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease.2005
Author(s)
Watanabe, K., Sugivama, S., Kugiyama, K., Honda, O., Fukushima, H., Koga, H., Horibata, Y., Hirai, T., Sakamoto, T., Yoshimura, M., Yamashita, Y., Ogawa, H.
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Journal Title
J Am Coll Cardiol 46
Pages: 2022-2030
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease2005
Author(s)
Koga, H., Sugiyama, S., Kugiyama, K., Watanabe, K., Fukushima, H., Tanaka, T., Sakamoto, T., Yoshimura, M., Jinnouchi, H., Ogawa, H.
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Journal Title
J Am Coll Cardiol 45
Pages: 1622-1630
Description
「研究成果報告書概要(欧文)」より
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