2008 Fiscal Year Final Research Report
The role of oxidative stress induced by NAD(P)H oxidase of leukocyte on cardiovascular damages in chronic kidney disease
| Project/Area Number |
17590830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
KIYOMOTO Hideyasu Kagawa University, 医学部附属病院, 講師 (00304585)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Akira 香川大学, 医学部, 教授 (10325334)
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| Project Period (FY) |
2005 – 2008
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| Keywords | NAD(P)Hオキシダーゼ / 慢性腎不全 / 酸化ストレス / 白血球 / 遺伝子発現 / 透析 |
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| Research Abstract |
慢性腎臓病患者より血液を採取し酸化ストレスの定量と白血球NAD(P)Hオキシダーゼの遺伝子発現を検討した。血液中の酸化ストレスは腎障害の進行に従い増加し、特に末期腎不全である血液透析群で有意な上昇を認めた。白血球からmRNAを抽出し、NAD(P)Hオキシダーゼのp22phox遺伝子発現を調査すると、同様に血液透析腎不全群で酸化ストレスは有意に上昇し、この上昇は透析膜の性能や透析期間とは関連がなかったが、心筋自己抗体の陽性者頻度が上昇した。
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[Journal Article] Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells2009
Author(s)
Kaifu K, Kiyomoto H, Hitomi H, Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa S, Nagata D, Nishiyama A, Kohno M.
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Journal Title
Nephrol Dial Transplant 24(3)
Pages: 809-815
Peer Reviewed
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[Journal Article] Interferon-γ enhances superoxide production in human mesangial cells via the JAK-STAT pathway2006
Author(s)
Moriwaki K, Kiyomoto H, Hitomi H, Ihara G, Kaifu K, Matsubara K, Hara T, Kondo N, Ohmori K, Nishiyama A, Fukui T, Kohno M
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Journal Title
Kidney Int 70(4)
Pages: 788-93
Peer Reviewed
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[Journal Article] Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells2006
Author(s)
Hitomi H, Fukui T, Moriwaki K, Matsubara K, Sun GP, Rahman M, Nishiyama A, Kiyomoto H, Kimura S, Ohmori K, Abe Y, Kohno M
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Journal Title
J Hypertens 24
Pages: 1089-95
Peer Reviewed
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[Journal Article] Effective LDL apheresis in a case of peripheral circulatory insufficiency in the forearm from repeated internal arteriovenous fistula surgeries2005
Author(s)
Hara T, Kiyomoto T, Moriwaki K, Higashiyama, Matsubara K, Hitomi H, Kondo N, Kaifu K, Ihara K, Ohmori K, Kohno M.
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Journal Title
日本アフェレシス学会雑誌 25(1)
Pages: 52-56
Peer Reviewed
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[Journal Article] Aldosterone Stimulates Reactive Oxygen Species Production through Activation of NADPH Oxidase in Rat Mesangial Cells2005
Author(s)
Miyata K, Rahman M, Shokoji T, Nagai Y, Zhang GX, Sun GP, Kimura S, Yukimura T, Kiyomoto H, Kohno M, Abe Y, Nishiyama A
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Journal Title
J Am Soc Nephrol 16(10)
Pages: 2906-2912
Peer Reviewed
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[Journal Article] Reduction of oxidized low-density lipoprotein by the long-term use of vitamin E-coated dialyzers in hemodialysis patients2005
Author(s)
Hara T, Takahashi N, Kiyomoto H, Moriwaki K, Fujioka H, Matsubara K, Kondo N, Shokoji T, Kiyomoto K, Hirohata M, Ishizu T, Akiyama K, Nishiyama A, Ohmori K, Kohno M
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Journal Title
Dialysis & Transplantation 33(4)
Pages: 197-202
Peer Reviewed
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