2006 Fiscal Year Final Research Report Summary
A new diagnostic criterion for myositis based on clinical and pathological findings
| Project/Area Number |
17590863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Jun The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40260492)
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| Project Period (FY) |
2005 – 2006
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| Keywords | myositis / classification / clinical / pathology |
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| Research Abstract |
This project aimed to propose new diagnostic criteria for myositis based on clinical and pathological findings. Firstly we analyzed the frequency of diagnostic clinical and pathological findings for myositis in biopsied muscles from 126 consecutive cases with PM/DM. We found that the immunohistochemical findings of aberrant expression of MHC-I antigen on non-necrotic fibers are frequent and are good marker for detecting inflammatory changes even with sparse inflammatory cells. We also found that the findings of the invasion of CD8 positive lymphocytes into non-necrotic fibers, which findings are specific for polymyositis are about 5%, and the frequency of the findings of perifascicular atrophy and the deposition of complement complexes on endomysial capillaries are 13% and 23% respectively. Ultrastrucural observation showed that the findings of tuburoreticular profiles in endothelial cells and destruction of endomysial capillaries are other good markers for diagnosis of dermatomyositis. The multifactor analysis between clinical and pathological factors did not show correlation between clinical and pathological findings. Following above results, we proposed a new diagnostic criterion based on skin changes and immunohistochemical and ultrastructural pathological findings in biopsied muscle. The validity of the new criteria was assessed through analyzing clinical pictures of consecutive 187 cases with PM/DM. The 187 cases were classified into 10 PM cases (6%), 94DM cases (50%), 62 unclassified myositis cases (33%) and 21 probable myositis cases. It was revealed that the clinical pictures between PM and DM are quite different and the cases with malignancy, collagen disease or pulmonary fibrosis were found only in DM group. The serum cytokine profiles (GM-CSF、 IFN-γ、IL-1b,2,4,5,6,8,10,TNF-a) assessed in 69 PM/DM cases also showed the difference between PM and DM groups. The results supported the validity of the proposed new criteria.
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[Journal Article] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.2007
Author(s)
Matsumoto L, Yamamoto T, Higashihara M, Sugimoto I, Kowa H, Shibahara J, Nakamura K, Shimizu J, Ugawa Y, Goto J, Dalmau J, Tsuji S
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Journal Title
Mov Disord. 31(Epub ahead of print)
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.2007
Author(s)
Matsumoto L, Yamamoto T, Higashihara M, Sugimoto I, Kowa H, Shibahara J, Nakamura K, Shimizu J, Ugawa Y, Goto J, Dalmau J, Tsuji S.
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Journal Title
Mov Disord. Jan 31(Epub ahead of print)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The pro-apoptotic human BH3-only peptide harakiri is expressed in crytococcus-infected perivascular macrophages in HIV-1 encephalitis patients.2006
Author(s)
Shinoe T, Wanaka A, Nikaido T, Kakuta Y, Masunaga A, Shimizu J, Duyckaerts C, Imaizumi K, Iwamoto A, Kanazawa I.
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Journal Title
Neurosci Lett. Jan 30,393(2-3)
Pages: 102-107
Description
「研究成果報告書概要(欧文)」より
