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2007 Fiscal Year Final Research Report Summary

Possible important role of DNA methylation in the induction of SLE ; relating to the new therapeutic strategy of SLE

Research Project

Project/Area Number 17591057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

SEKIGAWA Iwao  Juntendo University, School of Medicine, professor (80179332)

Project Period (FY) 2005 – 2007
KeywordsSystemic lupus ervthematosus / Human endogenous retovirus / Epigenetics / DNA methylation / DNMT- 1 / DNA microarrav / Estrogen
Research Abstract

The precise pathogenesis of systemic lupus erythematosus (SLE) is still unclear, however, autoantibodies are thought to be produced by increased transcription of certain elf antigens, such as human endogenous retroviruses (HERV). We have found that transcription of HERV is increased in patients with SLE as compared to normal individuals and this increase is related to quantitative decreasing of DNA methyl transferase (DNMT)-1. In addition, theses increasing effects of transcription of endogenous self antigens seem to be related to sex hormone such as estrogen. In order to investigate the effect of sex hormones on the gene expressions, changes in gene expression in peripheral blood mononuclear cells (PBMC) were examined during the menstrual cycle in females, under the comparison of gene expression of patients with SLE using DNA microarray methods. Based on these findings, certain genes (such as the tumor necrosis factor receptor superfamily, member 14; TNFRSF14, and signal regulatory protein, gamma; SIRPG) appear to contribute to gender difference of SLE. These findings may open the way to a new therapeutic strategy of SLE.

  • Research Products

    (20 results)

All 2008 2007 2006 2005

All Journal Article (20 results) (of which Peer Reviewed: 10 results)

  • [Journal Article] Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss2008

    • Author(s)
      Sekigawa I, Kaneda K, Kaneko H, et. al.
    • Journal Title

      Rheumatol Int 28

      Pages: 623-626

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Two cases of dermatomyositis associated with interstitial pneumonia:Comprehensive study of gene expression2008

    • Author(s)
      Kawasaki M, Kaneda K, Sekigawa I, et. al.
    • Journal Title

      Clin Exp Rheumatol 26

      Pages: 379-380

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor-α antibody therapy2008

    • Author(s)
      Sekigawa I, Yanagida M, Iwabuchi K, et. al.
    • Journal Title

      Clin Exp Rheumatol 26

      Pages: 261-

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss2008

    • Author(s)
      Sekigawa, I, Kaneda, K, Kaneko, H, et. al.
    • Journal Title

      Rheumatol Int 28

      Pages: 623-626

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two cases of dermatomyositis associated with interstitial pneumonia : Comprehensive study of gene expression2008

    • Author(s)
      Kawasaki, M, Kaneda, K, Sekigawa, I, et. al.
    • Journal Title

      Clin Exp Rheumatol 26

      Pages: 379-380

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor-a antibody therapy2008

    • Author(s)
      Sekigawa, I, Yanagida, M, Iwabuchi, K, et. al.
    • Journal Title

      Clin Exp Rheumatol 26

      Pages: 261-267

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Possible role of DNA methylation in the Review induction of systemic lupus erythematosus2007

    • Author(s)
      Sekigawa I, Kawasaki M, Ogasawara H, et. al.
    • Journal Title

      Current Rheumatology Review 3

      Pages: 11-16

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus2007

    • Author(s)
      Inui A, Ogasawara H, Sekigawa I, et. al.
    • Journal Title

      Clin Rheumatol 26, 1675- 26

      Pages: 1675-1678

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Seroprevalence of IgG anti-Toxoplasma antibodies in asymptomatic patients infected with human immunodeficiency virus in Janpan2007

    • Author(s)
      Naito T, Inui A, Sekigawa I, et. al.
    • Journal Title

      Intern Med 46

      Pages: 1149-1150

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Possible role of DNA methylation in the induction of systemic lupus erythematosus2007

    • Author(s)
      Sekigawa, I, Kawasaki, M, Ogasawara, H, et. al.
    • Journal Title

      Current Rheumatology Review 3

      Pages: 11-16

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus2007

    • Author(s)
      Inui, A, Ogasawara, H, Sekigawa, I, et. al.
    • Journal Title

      Clin Rheumatol 26

      Pages: 1675-1678

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Seroprevalence of IgG anti-Toxoplasma antibodies in asymptomatic patients infected with human immunodeficiency virus in Japan2007

    • Author(s)
      Naito, T, Inui, A, Sekigawa, I, et. al.
    • Journal Title

      Intern Med 46

      Pages: 1149-1150

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of human immunodeficiency virus type 1 integration by using a specific,sensitive and quantitative assay based on real-time polymerase chain reaction2006

    • Author(s)
      Yamamoto N, Tanaka C, Sekigawa I, et. al.
    • Journal Title

      Virus genes 32

      Pages: 105-113

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Expression of DNMT-1 in patients with atopic dermatitis2006

    • Author(s)
      Nakamura T, Sekigawa I, Ogasawara H, et. al.
    • Journal Title

      Arch Dermal Res 298

      Pages: 253-256

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] DNA methylation:its contribution to systemic lupus erythematosus2006

    • Author(s)
      Sekigawa I, Kawasaki M, Ogasawara H, et. al.
    • Journal Title

      Clin Exp Med 6

      Pages: 99-106

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of human immunodeficiency virus type 1 integration by using a specific, sensitive and quantitative assay based on real-time polymerase chain reaction2006

    • Author(s)
      Yamamoto, N, Tanaka, C, Sekigawa, I, et. al.
    • Journal Title

      Virus genes 32

      Pages: 105-113

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of DNMT-1 in patients with atopic dermatitis2006

    • Author(s)
      Nakamura, T, Sekigawa, I, Ogasawara, H, et. al.
    • Journal Title

      Arch Dermal Res 298

      Pages: 253-256

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] DNA methylation : its contribution to systemic lupus erythematosus2006

    • Author(s)
      Sekigawa, I, Kawasaki, M, Ogasawara, H, et. al.
    • Journal Title

      Clin Exp Med 6

      Pages: 99-106

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Interleukin-16 in patients with alopecia areata2005

    • Author(s)
      Tanyasiri K, Hira K, Sekigawa I, et. al.
    • Journal Title

      J Dermatol Sci 37

      Pages: 51-55

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Interleukin-16 in patients with alopecia areata2005

    • Author(s)
      Tanyasiri, K, Hira, K, Sekigawa, I, et. al.
    • Journal Title

      J Dermatol Sci 37

      Pages: 55-51

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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