2006 Fiscal Year Final Research Report Summary
The establishment of the novel diagnosis methods based on the analysis of the pathogenesis of the allergic diseases
| Project/Area Number |
17591080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
MATSUI Eiko Gifu University, Graduate school of medicine, Research associate, 大学院医学系研究科, 助手 (90334929)
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| Project Period (FY) |
2005 – 2006
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| Keywords | allergy / gene / the kit of diagnosis / cytokine / the cascade of arakidonic acid |
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| Research Abstract |
Allergic diseases are caused by complex interactions of genetic and environmental factors. We focused on IFN-γ and IL-12, which play pivotal roles in the suppressive system in allergic reactions and searched for genes related to the signal transduction.
(1) In this study, based on reports from all over the world including the above-mentioned results, we tried to genetically re-categorize allergy. There are 4 factors for categorization ; (1) antigen recognition site of the HLA class II-peptide-T cell receptor as a determinant of antigen specificity in allergic reactions, (2) B cell response in IgE production, (3) mediator production, and (4) target organs.
(2) There is a great inter-individual variation in the pathogenesis of allergy. Since rapid and precise assay is necessary to apply gene polymorphisms to clinical treatment/diagnosis, in other words, to provide tailor-made medicine, an allergy gene diagnosis kit using an invader assay was developed.
(3) In future studies, it is necessary to elucidate usefulness of these polymorphisms for the tailor-made medicine in allergic disease.
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[Journal Article] A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases.2005
Author(s)
Yoshikawa K, Matsui E, Kaneko H, Fukao T, Shinoda S, Fukutomi O, Aoki M, Kasahara K, Kondo N
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Journal Title
Int J Mol Med 16
Pages: 827-831
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Leaky phenotype of X-linked agammagobulinaemia in a Japaneses family.2005
Author(s)
Kaneko H, Kawamoto N, Asano T, Mabuchi Y, Horikosi H, Teramoto T, JIN-RONG, Matsui E, Kondo M, Fukao T, Kasahara K, Kondo N
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Journal Title
Clin Exp Immunol. 140
Pages: 520-523
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases2005
Author(s)
Yoshikawa K, Matsui E, Kaneko H, Fukao T, Inoue R, Teramoto T, Shinoda S, Fukutomi 0, Aoki M, Kasahara K, Kondo N
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Journal Title
Int J Mol Med. 16
Pages: 827-831
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Leaky phenotype of X-linked agammagobulinaemia in a Japaneses family2005
Author(s)
Kaneko H, Kawamoto N, Asano T, Mabuchi Y, Horikosi H, Teramoto T, JIN-RONG, Matsui E, Kondo M, Fukao T, Kasahara K, Kondo N
-
Journal Title
Clin Exp Immunol. 140
Pages: 520-523
Description
「研究成果報告書概要(欧文)」より
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