2006 Fiscal Year Final Research Report Summary
Analysis on the etiology and patho-physiology of neonatal thrombosis and the development of their therapy
| Project/Area Number |
17591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAKAHASHI Yukihiro Nara Medical University, School of Medicine, Professor, 医学部, 教授 (60142379)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Chiharu Nara Medical University, School of Medicine, Lecturer, 医学部, 講師 (60316073)
NISHIKUBO Toshiya Nara Medical University school of Medicine, School of Medicine, Associate Professor, 医学部, 助教授 (20208169)
YASUHARA Hajime Nara Medical University School of Medicine, School of Medicine, Assistant, 医学部, 助手 (00398447)
ARAI Ikuyo Nara Medical University School of Medicine, School of Medicine, Assistant, 医学部, 助手 (80405406)
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| Project Period (FY) |
2005 – 2006
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| Keywords | neonatal thrombosis / anti-thrombotic factor / protein C / TAFI / neonatal central catheter |
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| Research Abstract |
From the nation-wide survey of neonatal thrombosis in Japan supported by this foundation, the frequency of neonatal thrombosis in Japan was one-tenth lower than that of western countries. But, this survey was retrospective, and the diagnostic criteria were not fully assured. Therefore, it is unclear whether the difference is due to the race or the diagnostic skill. However, the etiology and patho-physiology of neonatal thrombosis from this survey were similar to those of the reports from western countries. The therapy of neonatal thrombosis in Japan was mostly conservative, but the fibrinolytic therapy, such as u-PA or t-PA, was used in some cases as in adult cases. But, the doses and the timing of the fibrinolytic therapy were not assured and then it needs to establish it near future. In this survey, the incidence of the genetic factors was very low. But in our experience, the plasma levels of protein C or another anti-thrombotic factor were very low comparing with the matched-aged-co
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ntrol values. And these factors gradually reached to the control values with the growth. Therefore, the genetic factor is not to be denied but it seems that the low anti-thrombotic factor is one of the risk factors in neonatal thrombosis.
Until now, the plasma levels of the coagulation and fibrinolytic factors in newborn are intensively investigated, but the recent researches and our studies demonstrate that it is important to evaluate it in the whole blood milieu included the platelets from the physiological perspective. At that time, it was suggested that the platelet-activation factors, such as small amount of thrombin and ADP exaggerated the coagulation, then, it is important to regulate these platelet-activation factors for the understanding the homeostasis and thrombosis in the newborn. From the study on the activated VII (VIIa) developed for the treatment of the bleedings in patients with hemophilia inhibiter, The VIIa pathway is important to physiologic haemostatic mechanism and Vila induced the effective homeostasis even in a few amount of platelets.
It is also necessary to reveal the physiological haemostatic regulatory system. Thrombin activatable inhibitory factor (TAFI) was established by the immunological method, we continued the measurement of plasma levels in newborn at several patho-physiological conditions. We revealed the some physiological significance in the newborn homeostasis and continued the study.
Finally, we will reveal the risk factors of neonatal thrombosis and establish the diagnostic criteria, and perform the prospective study near future. Less
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Research Products
(44 results)
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[Journal Article] ITP Committee of the Japanese Society of Pediatric Hematology Consensus guideline for diagnosis and treatment of childhood idiopathic thrombocytopenic purpura2006
Author(s)
Shirahata A, Ishii E, Eguchi H, Okawa H, Ohta S, Kaneko T, Konishi S, Sako M, Sekine I, Takahashi Y, Taki M, Tsuchiya S, Fujisawa K, Bessho F, Horikoshi Y, Mimaya J, Akatsuka J, Miyazaki S.
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Journal Title
Int J Hemato1. 83
Pages: 29-38
Description
「研究成果報告書概要(欧文)」より
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[Book] 小児慢性疾患診療マニ ュアル2006
Author(s)
高橋幸博, 吉岡 章.監修, 加藤忠明 編集, 柳澤正義, 別所文雄, 内山聖, 森川昭廣, 藤枝憲二, 武井修治, 杉原茂孝, 伊藤道徳, 小池健一, 飯沼一宇, 白木和夫, 原田正平
Total Pages
473-476
Publisher
診断と治療社 東京
Description
「研究成果報告書概要(欧文)」より
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