2007 Fiscal Year Final Research Report Summary
The changes of cytologic features of melanocytes after verious treatments
| Project/Area Number |
17591159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KIKUCHI Kanako The University of Tokyo, Hospital, Assuciate Professor (60186195)
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| Co-Investigator(Kenkyū-buntansha) |
KOMINE Mayumi The University of Tokyo, 医学部附属病院, Assistant Professor (00282632)
KADONO Takafumi The University of Tokyo, 医学部附属病院, Assistant Professor (80292910)
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| Project Period (FY) |
2005 – 2007
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| Keywords | melanocytes / ultraviolet B / Vitiligo / psoriasis |
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| Research Abstract |
We treated 5 patients considered to have pseudoscleroderma associated by various malignancies from 1994 to 2002 in our department. Sixty-six of 71 patients with sclerotic skin changes were diagnosed as systemic sclerosis (SSc) while 5 patients (7%) were diagnosed as pseudoscleroderma associated with cancer during the period. Serum basic fibroblast growth factor (bFGF) levels in the 5 patients with pseudoscleroderma were highly elevated compared to the levels in controls. Elevated expression of bFGF was detected on fibroblasts of the affected skin and in one lung cancer tissue sample that was taken by excision.
Narrowband ultraviolet B (NBUVB, TL-01) lamps are powerful therapeutic tools for several skin diseases, such as psoriasis and vitiligo. Elevated uric acid serum levels are a frequent finding in psoriasis and it is generally believed that there is an association between hyperuricemia and psoriasis. Exacerbation of psoriasis by UV energy would be expected to be accompanied by increa
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sed nucleic acid production and hyperuricemia. However, vitiligo vulgaris is not thought to be predisposed toward hyperuricemia. We found four generalized vitiligo patients who demonstrated hyperuricemia after NBUVB treatments. We measured the time course of changes in serum levels of the melanin-related metabolite 5-S-cysteinyldopa (5-S-CD) in psoriasis patients undergoing NBUVB phototherapy. Eleven Japanese patients with generalized psoriasis vulgaris received NBUVB treatment 5 times per week, with an initial dose of 0.1J/cm^2. The dose was increased by 10% to 20% per treatment for more than 20 treatments. Serum samples were taken before, and 3, 7, 10, 14, 28 days after the phototherapy. After 4 weeks of NBUVB treatment, 9 of 11 patients were in remission. Two patients were dropped from the investigation before day 28 because of other complications. The Mean level of 5-S-CD in serum was significantly elevated on days 7, 10 14, and 28 compared with that before the phototherapy. The serum 5-S-CD level peaked on day 10. Less
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