2006 Fiscal Year Final Research Report Summary
A research on the dendritic cell activation in psoriasis
| Project/Area Number |
17591188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | JIKEI UNIVERSITY (2006)
St. Marianna University School of Medicine (2005) |
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Principal Investigator |
HIGAKI Megumu Jikei University, School of Medicine, Professor, 医学部, 教授 (70156553)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Psoriasis / Keratinocytes / CD208 / Dendritic cells / Differentiation / Lysosome / Immunohistochemistry |
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| Research Abstract |
Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and infiltration of inflammatory leukocytes. Since the important role of innate immunity involving dendritic cells (DCs) and keratinocytes has been suggested in psoriasis, we immunohistochemically examined the expression of DC markers such as CD1a,CD83,CD207 (Langerin), CD208 (DC-LAMP), and CD209 (DC-SIGN) in psoriatic skin. Interestingly, CD208 was strongly expressed in suprabasal layer keratinocytes in addition to DCs in the perivasular lesions of the psoriatic dermis. Furthermore, the enhanced expression of CD208 in the perinuclear lesions of IFN-g-/TPA-stimulated keratinocytes was observed in vitro. Since a defect of the granular layer in psoriatic lesions has been recognized, increased expression of lysosome-related CD208 in the suprabasal keratinocytes of psoriatic lesions might represent aberrant epidermal differentiation. Additionally, these CD208-positive keratinocytes possessing antigen-processing activity might play a key role as antigen-presenting cells in psoriatic skin.
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Author(s)
Jong-Won Park, Kurosawa S, Aizawa H, Hamano H, Harada Y, Asano S, Mizushima Y, Higaki M.
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Journal Title
BIOSENS BIOELECTRON 22
Pages: 409-414
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Pharmacokinetics and enhanced PKR response in patients with chronic hepatitis C treated with pegylated interferon alpha-2b and ribavirin.2006
Author(s)
Asahina Y, Izumi N, Umeda N, Hosokawa T, Ueda K, Doi F, Tsuchiya K, Nakanishi H, Matsunaga K, Kitamura T, Kurosaki M, Uchihara M, Higaki M, Miyake S.
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Journal Title
J VIRAL HEPATITIS
Pages: doi:10.1111/j.1365-2893.2006.00803.x
Description
「研究成果報告書概要(欧文)」より
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