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2007 Fiscal Year Final Research Report Summary

Objective diagnostic method for schizophrenia using structural and functional neuroimages

Research Project

Project/Area Number 17591201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

KAWASAKI Yasuhiro  University of Toyama, Neuropsychiatry, Assistant Professor (80242519)

Co-Investigator(Kenkyū-buntansha) SUZUKI Michio  University of Toyama, Neuropsychiatry, Professor (40236013)
SUMIYOSHI Tomiki  University of Toyama, Neurcpsychiatry, Associate professor (80286062)
TAKAHASHI Tutomu  University of Toyama, Neuropsychiatry, Teaching assistant (60345577)
IWATA Takuya  University of Toyama, Neuropsychiatry, Teaching assistant (20324048)
KURACHI Masayoshi  University of Toyama, Neurcpsychiatry, Professor (80019603)
Project Period (FY) 2005 – 2007
KeywordsSchizophrenia / Magnetic resonance imaging / Event related potential / Diagnosis
Research Abstract

Existing operational diagnostic systems for major psychiatric disorders such as schizophrenia are based solely on clinical manifestations and associated psycho-social impairments. Because the laboratory measurements of the brain are stable relative to clinical manifestations, structural and functional neuroimagings might provide additional information to psychiatric diagnostic systems for more valid classifications. Tb identify the correlative pattern of neuro-physiological brain activity and gray matter distribution those best discriminate schizophrenia patients from healthy subjects, we applied discriminant function analysis techniques using the multivariate linear model and the low-resolution brain electromagnetic tomography (LORETA) and the voxel-based morphometry (VBM). These studies dose not revealed significant correlative pattern of LORETA neuro-physiological activity as well as VBM gray matter distribution. Obtained results can discriminate between the male patients with schizophrenia and the male control subjects. These patterns allowed favorable classification of subjects into different groups. Further elaboration of the present method may contribute to the clinical diagnosis of schizophrenia in the future.

  • Research Products

    (24 results)

All 2008 2007 2006 2005 Other

All Journal Article (13 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry.2008

    • Author(s)
      Kawasaki Y., Suzuki M., Takahashi T., et. al.
    • Journal Title

      Biological Psychiatry 63

      Pages: 793-800

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] McGuire P, Seto H, Kurachi M: Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry2008

    • Author(s)
      Kawasaki, Y, Suzuki, M, Takahashi, T, Nohara, S
    • Journal Title

      Biol. Psychiatry 63

      Pages: 793-800

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls.2007

    • Author(s)
      Kawasaki Y., Suzuki M., Kherif F., et. al.
    • Journal Title

      Neuroimage 34

      Pages: 235-242

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia.2007

    • Author(s)
      Kawasaki Y., Sumiyoshi T., Higuchi Y., et. al.
    • Journal Title

      Schizophrenia Research 94

      Pages: 164-171

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Brief assessment of cognition in schizophrenia. Varidation of the Japanese version. Psychiat2007

    • Author(s)
      Kaneda, Y, Sumiyoshi, T, Keeefe, R, Ishimoto, Y, Numata, S, Ohmori, T
    • Journal Title

      Clin Neuroschi 61

      Pages: 602-609

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia2007

    • Author(s)
      Kawasaki, Y, Sumiyoshi, T, Higuchi, Y, Ito, T, Takeuchi, T, Kurachi, M
    • Journal Title

      Schizophr. Res 94

      Pages: 164-171

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls2007

    • Author(s)
      Kawasaki, Y, Suzuki, M, Kherif, F, Takahashi, T, Zhou, SY, Nakamura, K, Matsui, M, Sumiyoshi, T, Seth, H, Kurachi, M
    • Journal Title

      Neuroimage 34

      Pages: 235-42

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia: A preliminary report2007

    • Author(s)
      Takahashi, T, Suzuki, M, Tanino, R, Zhou, SY, Hagino, H, Niu, L, Kawasaki, Y, Seth, H, Kurachi, M
    • Journal Title

      Psychiatry Res. Neuroimaging 154

      Pages: 209-219

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum2006

    • Author(s)
      Takahashi, T, Suzuki, M, Zhou, S-Y, Tanino, R, Hagino, H, Kawasaki, Y, Matsui, M, Seth, H, Kurachi, M
    • Journal Title

      Schizophr. Res 83

      Pages: 131-143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri2006

    • Author(s)
      Takahashi, T, Suzuki, M, Zhou, S-Y, Tanino, R, Hagino, H, Niu, L, Kawasaki, Y, Seth, H, Kurachi, M
    • Journal Title

      Schizophr. Res 87

      Pages: 116-126

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Electrical brain activity and response to olanzapine in schizophrenia: A study with LORETA images of P300. Prog2006

    • Author(s)
      Sumiyoshi, T, Higuchi, Y, Kawasaki, Y, Matsui, M, Kato, K, Yuuki, H, Arai, H, Kurachi, Air
    • Journal Title

      Neuro-Psychopharmacol. & Biol. Psychiatry 30

      Pages: 1299-1303

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Neuropsychological correlates of an attention-related negative component elicited in an auditory oddball paradigm in schizophrenia2005

    • Author(s)
      Higashima, M, Nagasawa, T, Oka, T, Tsukada, T, Okamoto, T, Kornai, Y, Kawasaki, Y, Koshino, Y
    • Journal Title

      Neuropsychobiology 51

      Pages: 177-182

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Male-specific volume expansion of the human hippocampus during adolescence2005

    • Author(s)
      Suzuki, M, Hagino, H, Nohara, S, Zhou, S-Y, Kawasaki, Y, Takahashi, T, Matsui, M, Seth, H, Ono, T, Kurachi, M
    • Journal Title

      Cereb. Cortex 15

      Pages: 187-193

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Implementing clinical service young people at risk of developing psychosis in Toyama Japan2008

    • Author(s)
      Kawasaki, Y, Suzuki, M., Sumiyoshi, T., Takahashi, T., Nishiyama, S., Matui , M., Kurachi, M., Kazukawa, S
    • Organizer
      The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
    • Place of Presentation
      Montreux, Switzerland
    • Year and Date
      2008-02-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Voxel-based analysis of P300 elecctrophysiological topography associated with positive and negative symptoms of schizophrenia2008

    • Author(s)
      Kawasaki, Y., Sumiyoshi, T., Higuchi, Y. Ito, T., Takeuchi, M., Suzuki, M
    • Organizer
      The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
    • Place of Presentation
      Montreux, Switzerland
    • Year and Date
      2008-02-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Clinical service for young people at risk of deveroping psychosis: Toyama early detection & intervention project.2007

    • Author(s)
      Kawasaki Y., Suzuki M., Takahashi T., et. al.
    • Organizer
      The XIX World Congress of the World Association for Social Psychiartry
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2007-10-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Clinical service for young people at risk of deveroping psychosis: Toyama early detection & intervention project2007

    • Author(s)
      Kawasaki, Y., Suzuki, M., Takahashi, T., Iwata, T., Sumiyoshi, T., Matui, M., Kurachi, M., Kazukawa, S
    • Organizer
      The XIX World Congress of the World Association for Social Psychiartry
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2007-10-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry2007

    • Author(s)
      Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M., McGuire, P
    • Organizer
      The 20th European College of Neuropsychopharmacology Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2007-10-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Multivariate voxel based morphometry to map structural characteristics associated with gender differences in schizophrenia2006

    • Author(s)
      Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M
    • Organizer
      The19th Congress of the European College of Neuropsychopharmacology
    • Place of Presentation
      Paris
    • Year and Date
      20060900
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Can event-related potentials be of diagnostic value for schizophrenia?2006

    • Author(s)
      Kawasaki, Y., Sumiyoshi, T., Higuchi, Y., Takeuchi, M., Ito, T., Kurachi, M
    • Organizer
      The 28th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Edinburgh
    • Year and Date
      20060900
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Can electrophysiological findings be of diagnostic value for schizophrenia2006

    • Author(s)
      Kawasaki, Y, Sumiyoshi, T., Higuchi, Y., Takeuchi, M., Kurachi, M
    • Organizer
      Association of European Psychiatrists-14th European Congress of Psychiatry
    • Place of Presentation
      Nice
    • Year and Date
      20060300
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Can structural MRI findings be of diagnostic value for schizophrenia2005

    • Author(s)
      Kawasaki, Y., Suzuki, M., Takahashi, T., Kurachi, M
    • Organizer
      The 2nd ECNS-ISNIP Joint Meeting
    • Place of Presentation
      Munich, Germany
    • Year and Date
      20050900
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 精神疾患の脳画像解析・診断学「III.脳画像検査の臨床応用」2008

    • Author(s)
      平安良雄、笠井清登 編 川崎康弘、鈴木道雄, ら 著
    • Total Pages
      127
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.med.u-toyama.ac.jp/neuropsychiatry/index-kokoro.html

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Published: 2010-02-04  

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