2007 Fiscal Year Final Research Report Summary
The study related to the mechanism of the onset for methamphetamine dependence in Japanese and Taiwanese populations.
| Project/Area Number |
17591203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
ANITHA Ayyappan Pillai Hamamatsu University School of Medicine, The medical department, Assistant Professor (70377753)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kazahiko Hamamatsu University School of Medicine, The medical department, Senior Assistant Professor (80263911)
MORI Norio Hamamatsu University School of Medicine, The medical department, Professor (00174376)
TAKEI Noriyoshi Hamamatsu University School of Medicine, Research Center for Child Mental Development United Graduate School of Child Development, Professor (80206937)
MINABE Yoshio Hamamatsu University School of Medicine, Kanazawa University Hospital, Professor (60181947)
KAWAI Masayoshi Hamamatsu University School of Medicine, The medical department, Senior Assistant Professor (30283352)
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| Project Period (FY) |
2005 – 2007
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| Keywords | methamphetamine / dependence |
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| Research Abstract |
SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes : a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.
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[Journal Article] An association study of monoamine oxidase A(MAOA)gene polymorphism in methamphetamine psychosis2009
Author(s)
Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
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Journal Title
Neurosci Lett 455
Pages: 120-123
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers2008
Author(s)
Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
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Journal Title
Ann N Y Acad Sci 1139
Pages: 49-56
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association Analysis of SOD2 Variants with Methamphetamine Psychosis in Japanese and Taiwanese Populations2006
Author(s)
Nakamura K, Chen C-K, Sekine Y, Iwata Y, Anitha A, Loh E-W, Takei N, Suzuki A, Kawai M, Takebyashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball D, Yoshikawa T, Shih-Ku Lin S-K, Mori N.
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Journal Title
Hum Genet 120
Pages: 243-252
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder2006
Author(s)
Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
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Journal Title
Psychiatr Genet 16
Pages: 133-138
Description
「研究成果報告書概要(欧文)」より
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