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2007 Fiscal Year Final Research Report Summary

Comprehensive research project of diagnosis and treatment of dementia with Lewy bodies

Research Project

Project/Area Number 17591207
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNagoya University

Principal Investigator

UMEGAKI Hiroyuki  Nagoya University, University Hospital, Assistant Professor (40345898)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yusuke  Nagoya University, Granduate school of Medicine, Designated assistant Professor (90378167)
AKATSU Hnroyasu  Fukushimura Hosipital, Choju Medical Institute, Vice-director (00399734)
Project Period (FY) 2005 – 2007
Keywordsdopamine / acetylcholine / cognitive function / dementia with Lewv bodies / Alzheimer's disease / hippocampus / institution placement / motor function
Research Abstract

In the current study we investigated the pathophysiology of dementia with Lewy bodies (DLB) to explore the new strategy of treatment of this disease. What we have shown are below.
1, By studying the autopsy brains of patients with DLB and Alzheimer's disease (AD), we found that at admission to residential hallucinations, impaired wakefulness, impairment of activities of daily living and emotional disturbance were more frequent at admission in DLB patients than in AD patients. Moreover, DLB patients had higher scores in the cognitive test at admission and shorter time from onset of dementia to institutionalization than did AD patients.
2, DLB patients have severer impairment of the cholinergic neurons projecting to the hippocampus compared to the normal elderly and patients with AD.
3, By using the animal models with memory impairment induced by the cholinergic neuronal dysfunction, the injection of dopamine agonists into the hippocampus ameliorated the memory impairment.
Taken all these together we demonstrated that DLB is a disease that is very distinguished from Alzheimer's disease in terms of disease course and care burden and the dual therapy strategy to enhance both cholinergic and dopaminergic neuronal systems has relevance. We have started the combination therapy with L-dopa and cholinesterase inhibitior for DLB. Four DLB patients have taken treatment with L-dopa (62.8mg/day) for 3 month. So far we have not reached the conclusion on the efficacy of this treatment because of the small number of the patients involved

  • Research Products

    (44 results)

All 2008 2007 2006 2005

All Journal Article (38 results) (of which Peer Reviewed: 19 results) Presentation (6 results)

  • [Journal Article] Factors Associated with Lower Mini Mental State Examination Scores in Elderly Japanese Diabetes Mellitus Patients.2008

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      Neurobiol Aging (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Long-term effects of a loose restriction of carbohydrates diet on HbAlc levels, BMI and tapering of sulfonylureas in type2 diabetes: a two-year follow-up study.2008

    • Author(s)
      Haimoto H, Iwata M, Wakai K, Umegaki H
    • Journal Title

      Diab Res Clin Prac. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Glucose Control Levels, Ischemic Brain Lesions, and Hyperinsulinemia were Associated with Cognitive Dysfunction in Diabetic Elderly.2008

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      Age and Ageing (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Discontinuation of Donepezil for the Treatment of Alzheimer's Disease in Geriatric Practice.2008

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      Int. Psychogeriatr. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of the entorhinal cortex on diurnal ACTH and corticosterone release inrats.2008

    • Author(s)
      Zhu W, Zhang R, Changchun H, Umegaki H
    • Journal Title

      Neuroendocrinology letters (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] AGING OF THE STRIATUM: Mechanisms and Interventions2008

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      AGE (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Visceral fat contribution of insulin resistance in the elderly.2008

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      J Am Geriatr Soc. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Factors Associated with Lower Mini Mental State Examination Scores in Elderly Japanese Diabetes Mellitus Patients2008

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      Neurobiol Aging (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Long-term effects of a loose restriction of carbohydrates diet on HbAlc levels, BMI and tapering of sulfonylureas in type 2 diabetes : a two-year follow-up study2008

    • Author(s)
      Haimoto, H, Iwata, M, Wakai, K, Umegaki, H
    • Journal Title

      Diab Res Clin Prac (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Glucose Control Levels, Ischemic Brain Lesions, and Hyperinsulinemia were Associated with Cognitive Dysfunction in Diabetic Elderly2008

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      Age and Ageing (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Discontinuation of Donepezil for the Treatment of Alzheimer's Disease in Geriatric Practice2008

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      Int. Psychogeriatr (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats2008

    • Author(s)
      Zhu, W, Zhang, R, Changchun, H, Umegaki, H
    • Journal Title

      Neuroendocrinology letters (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] AGING OF THE STRIATUM : Mechanisms and Interventions2008

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      AGE (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ZVisceral fat contribution of insulin resistance in the elderly2008

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      JAm Geriatr Soc (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Attitudes toward disclosing the diagnosis of dementia in Japan.2007

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      Int. Psychogeriatr. 19

      Pages: 253-265

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Attitudes toward disclosing the diagnosis of dementia in Japan2007

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      Int. Psychogeriatr 19

      Pages: 253-265

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Depletion of cholinergic neurons in nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.2006

    • Author(s)
      Fujishiro H, Umegaki H
    • Journal Title

      Acta Neuropathol. 111(2)

      Pages: 109-114

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Behavioral, Psychological, and Physical Symptoms in Group Homes for the Older Adults with Dementia.2006

    • Author(s)
      Onishi, J, Suzuki Y, Umegaki H, et. al.
    • Journal Title

      Int Psychogeriatr. 3

      Pages: 1-12

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Factors associated with cognitive impairment in elderly diabetes mellitus patients.2006

    • Author(s)
      Suzuki M, Umegaki H, et. al.
    • Journal Title

      J Am Geriatr Soc. 54(3)

      Pages: 558-559

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cognitive Function in the Elderly with Diabetes Mellitus.2006

    • Author(s)
      Umegaki H, Iguchi A
    • Journal Title

      J Clin Biochem Neutr. 38(1)

      Pages: 19-24

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cognitive dysfunction associates with white matter hyperintensities and subcorticalatrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese Elderly Diabetes Intervention Trial(J-EDIT)2006

    • Author(s)
      Akisaki T, Sakurai T, Takata T, Umegaki H, et. al.
    • Journal Title

      Diabetes/Metabolism Research and Reviews 22(5)

      Pages: 376-384

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Association between insulin resistance and cognitive function in elderly diabetic patients.2006

    • Author(s)
      Suzuki M, Umegaki H, et. al.
    • Journal Title

      Geriatr. Gerotr. Intr. 6

      Pages: 254-259

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Functional Recovery of the Striatal Cholinergic System in Aged Rats by Adenoviral Vector-mediated Gene Transfer of Dopamine D_2 Receptor.2006

    • Author(s)
      Umegaki H, et. al.
    • Journal Title

      Mech Ageing Dev. 127(10)

      Pages: 813-815

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Depletion of cholinergic neurons in nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies2006

    • Author(s)
      Fujishiro, H, Umegaki, H
    • Journal Title

      Acta Neuropathol 111(2)

      Pages: 109-114

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Behavioral, Psychological, and Physical Symptoms in Group Homes for the Older Adults with Dementia2006

    • Author(s)
      Onishi, J, Suzuki, Y, Umegaki, H, et. al.
    • Journal Title

      Int Psychogeriatr 3

      Pages: 1-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Factors associated with cognitive impairment in elderly diabetes mellitus patients2006

    • Author(s)
      Suzuki, M, Umegaki, H, et. al.
    • Journal Title

      JAm Geriatr Soc 54(3)

      Pages: 558-559

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cognitive Function in the Elderly with Diabetes Mellitus.2006

    • Author(s)
      Umegaki, H, Iguchi, A
    • Journal Title

      J Qin Biochem Neutr 38(1)

      Pages: 19-24

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cognitive dysfunction associates with white matter hyper-intensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitusJapanese Elderly Diabetes Intervention Trial (J-EDIT)2006

    • Author(s)
      Akisaki, T, Sakurai, T, Takata, T, Umegaki,H, et. al.
    • Journal Title

      Diabetes/ Metabolism Research and Reviews 22(5)

      Pages: 376-384

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association between insulin resistance and cognitive function in elderly diabetic patients2006

    • Author(s)
      Suzuki, M, Umegaki, H, et. al.
    • Journal Title

      Geriatr. Gerotr. Intr 6

      Pages: 254-259

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functional Recovery of the Striatal Cholinergic System in Aged Rats by Adenoviral Vector-mediated Gene Transfer of Dopamine D2 Receptor2006

    • Author(s)
      Umegaki, H, et. al.
    • Journal Title

      Mech Ageing Dev 127(10)

      Pages: 813-815

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus.2005

    • Author(s)
      Adeli-Rankouhi S, Umegaki H, et. al.
    • Journal Title

      Neuroendocrinol lett. 26

      Pages: 225-230

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects onethanol drinking.2005

    • Author(s)
      Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, Umegaki H, et. al.
    • Journal Title

      Life Sciences 77

      Pages: 130-139

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dopamine D_2 receptor has a role in memory function. Implications fordopamine-acetylcholine interaction in the ventral hippocampus.2005

    • Author(s)
      Fujishiro H, Umegaki H, et. al.
    • Journal Title

      Psychopahrmacology 16

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Influence of behavioral and psychological symptoms of dementia(BPSD)and environment of care on caregivers' burden.2005

    • Author(s)
      Onishi J, Suzuki Y, Umegaki H, et. al.
    • Journal Title

      Arch Gerontol Geriatr. 41(2)

      Pages: 159-168

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus2005

    • Author(s)
      Adeli-Rankouhi, S, Umegaki, H, et. al.
    • Journal Title

      Neuroendocrinol lett 26

      Pages: 225-230

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dopamine D2R DNA transfer in dopamine D2 receptor -deficient mice : Effects on ethanol drinking2005

    • Author(s)
      Thanos, PK, Rivera, SN, Weaver, K., Grandy, DK, Rubinstein, M, Umegaki, H, et. al.
    • Journal Title

      Life Sciences 77

      Pages: 130-139

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dopamine D2 receptor has a role in memory function. Implications for dopamine-acetylcholine interaction in the ventral hippocampus2005

    • Author(s)
      Fujishiro, H, Umegaki, H, et. al.
    • Journal Title

      Psychopahrmacology 16

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Influence of behavioral and psychological symptoms of dementia (BPSD) and environment of care on caregivers' burden2005

    • Author(s)
      Onishi, J, Suzuki, Y, Umegaki, H, et. al.
    • Journal Title

      Arch Gerontol Geriatr 41(2)

      Pages: 159-168

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] レビー小体型認知症の診断治療に関する総合研究2007

    • Author(s)
      梅垣宏行
    • Organizer
      第49回日本老年学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Comprehensive research project of diagnosis and treatment of dementia with Lewy bodies2007

    • Author(s)
      Hiroyuki, Umegaki
    • Organizer
      The 49th Annnual Meeting of the Japan Geriatrics Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D2 receptor.2006

    • Author(s)
      Hiroyuki Umegaki
    • Organizer
      36th annual meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2006-10-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D2 receptor2006

    • Author(s)
      Hiroyuki, Umegaki
    • Organizer
      36th annual meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2006-10-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ドーパミンの認知機能改善作用のレビー小体痴呆への応用2005

    • Author(s)
      梅垣宏行
    • Organizer
      第6回老年疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Application of dopamine for the cognitive enhancement2005

    • Author(s)
      Hiroyuki, Umegaki
    • Organizer
      6th Rounen Shikkan Kenkyukai
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-07-16
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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