2006 Fiscal Year Final Research Report Summary
The Correlation between Cytokines and Depressive State in General Aged Population: The Imari Study
| Project/Area Number |
17591220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Saga University |
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Principal Investigator |
YAMADA Shigeto Saga University, Faculty of Medicine, Professor, 医学部, 教授 (20158190)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIKAWA Hideki Saga University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (90380758)
UEKI Hiroshi Saga University, Faculty of Medicine, Instructor, 医学部, 助手 (40336128)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Depression / Cytokine |
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| Research Abstract |
Previous studies have been suggested that proinflammatory cytokines and their soluble receptors or receptor antagonists are involved in the etiopathogenesis of depressive disorders. However, it is not clear whether or not the activated secretion of proinflammatory cytokines in one of the causes or one of the effects of depressive disorders. We herein report that the correlation between cytokines and depressive state in general aged population. Ninety-nine (24 men and 75 women) subjects who lived in Kurokawa Region, Imari City, Saga, Japan, were participated in the present study. We measured plasma concentrations of six cytokines such as interleukin (IL)-1β, IL-2, IL-6, tumor necrosis factor (TNF) α, soluble IL-2 receptor (sIL-2R) and sIL-6R. We evaluated depressive state of the subjects with Beck Depression Inventory-Second Edition (BDI-II). IL-1 levels were significantly correlated with the scores of BDI-II (p = 0.027, p = 0.222), whereas the other five cytokine levels were not correlated. These findings suggested that IL-1 is involved in the pathogenesis of pre-onset depressive disorders.
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