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2006 Fiscal Year Final Research Report Summary

Cortical excitability in schizophrenic patients studied by transcranial magnetic stimulation.

Research Project

Project/Area Number 17591228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

SHINOSAKI Kazuhiro  Wakayama medical university, School of Medicine, Neuropsychiatry, Professor, 医学部, 教授 (40215984)

Co-Investigator(Kenkyū-buntansha) UKAI Satoshi  Wakayama medical university, School of Medicine, Lecturer, 医学部, 講師 (80324763)
MATSUMOTO Naokai  Wakayama medical university, School of Medicine, Research associate, 医学部, 助手 (60326361)
TSUJI Tomikimi  Wakayama medical university, School of Medicine, Research associate (10347586)
SHOUYAMA Masaru  Wakayama medical university, School of Medicine, Research associate (70364081)
KOSE Asami  Wakayama medical university, School of Medicine, Research associate (10405425)
Project Period (FY) 2005 – 2006
Keywordsschizophrenia / transcranial magnetic stimulation / startled auditory stimulation / TMS / PPI / GABA / NMDA
Research Abstract

Short intracortical inhibition (SICI) of motor cortex is obtained with paired transcranial magnetic stimulation (TMS) and is probably largely mediated by neurons containing γ-aminobutyric acid (GABA). Prepulse inhibition (PPI) is obtained using startled auditory paired stimulation and probably reflects the Dopamine-NMDA function.
Impaired SICI was found in schizophrenic patients with typical anti-psychotics medications, high BPRS core and low GAF score, and more frequently found in disorganized type than in delusional type. Impaired SICI was thought to be a trait marker in some patients,.
PPI abnormality was found in 60ms and 480ms conditions in schizophrenic patients. No significant correlation was found between PPI and demographic scores (onset age, duration of illness, total amount of medication and nicotine per day), mental state measurements (PANSS, GAF) and cognitive function scores (MMSE, FAB, ATMT), suggesting that PPI may well became a trait marker.
SICI, PPI appear to well become a physiological stool for early intervention and a prediction of clinical outcome.

  • Research Products

    (18 results)

All 2007 2006 2005 Other

All Journal Article (15 results) Book (3 results)

  • [Journal Article] 体性感覚野へのrTMSによるHFOsの変化2007

    • Author(s)
      鵜飼聡, 他
    • Journal Title

      臨床脳波 49

      Pages: 83-89

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Donepezil in the treatment of musical hallucinations.2007

    • Author(s)
      Ukai S, Yamamoto M, Tanaka M, Shinosaki K, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. 61(2)

      Pages: 190-2

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese 'Shiritori' Word Generation Task.2006

    • Author(s)
      Yamamoto M, et al.
    • Journal Title

      Neuropsychobiology 53

      Pages: 215-222

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Right parietal activation during delusional state in episodic interictal psychosis of epilepsy : a report of two cases.2006

    • Author(s)
      Ishii R, et al.
    • Journal Title

      Epilepsy Behav. 9

      Pages: 367-372

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 情動を脳波で測定する2006

    • Author(s)
      水野(松本)由子, 他
    • Journal Title

      臨床脳波 48

      Pages: 629-637

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 「統合失調症は神経変成疾患か?」生理学的観点から-MMN,PPIを中心に-2006

    • Author(s)
      鵜飼聡, 他
    • Journal Title

      脳21 9

      Pages: 403-405

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 自傷行為から長期の身体拘束を要した統合失調症にvalporateが有効であった1例2006

    • Author(s)
      正山勝, 他
    • Journal Title

      臨床神経薬理 10 2006 119-123 10

      Pages: 119-123

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 統合失調症の認知リハビリテーション2006

    • Author(s)
      松本直起, 他
    • Journal Title

      Schizophrenia Frontier 7

      Pages: 262-256

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ECTとrTMSによるうつの治療2006

    • Author(s)
      篠崎和弘, 他
    • Journal Title

      脳と精神の医学 17

      Pages: 223-230

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese 'Shiritori' Word Generation Task.2006

    • Author(s)
      Yamamoto M, Ukai S, Shinosaki K, Ishii R, Kawaguchi S, Ogawa A, Mizuno-Matsumoto Y, Fujita N, Yoshimine T, Takeda M.
    • Journal Title

      Neuropsychobiology. 53(4)

      Pages: 215-22

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Right parietal activation during delusional state in episodic interictal psychosis of epilepsy : a report of two cases.2006

    • Author(s)
      Ishii R, Canuet L, Iwase M, Kurimoto R, Ikezawa K, Robinson SE, Ukai S, Shinosaki K, Hirata M, Yoshimine T, Takeda M.
    • Journal Title

      Epilepsy Behav. 9(2)

      Pages: 367-72

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 統合失調症と前頭前野.2005

    • Author(s)
      石井良平, 鵜飼聡, 岩瀬真生, 篠崎和弘, 武田雅俊
    • Journal Title

      Clinical Neuroscience 23

      Pages: 223-230

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of regional cerebral blood flow in fahr disease with schizophrenia-like psychosis : a case report.2005

    • Author(s)
      Shouyama M, Kitabata Y, Kaku T, Shinosaki K.
    • Journal Title

      AJNR Am J Neuroradiol. 26(10)

      Pages: 2527-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Wavelet-crosscorrelation analysis : Non-stationary analysis of neurophysiological signals.2005

    • Author(s)
      Mizuno-Matsumoto Y, Ukai S, Ishii R, Date S, Kaishima T, Shinosaki K, Shimojo S, Takeda M, Tamura S, Inouye T.
    • Journal Title

      Brain Topogr. 17(4)

      Pages: 237-52

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Donepezil in the treatmentof musicalhallucinations

    • Author(s)
      Ukai K, et al.
    • Journal Title

      Pyschiatry and clinical neurosciences (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 統合失調症の前頭葉機能の脳磁図解析. 「前頭葉 : その機能とネットワーク、神経科学の基礎と臨床XII」(板倉徹編)2005

    • Author(s)
      篠崎和弘
    • Total Pages
      10
    • Publisher
      ブレーン出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 高齢者に特有な精神症候群7. 音楽性幻聴. 「現代老年精神医療」(武田雅俊編)2005

    • Author(s)
      鵜飼聡, 山本雅清, 篠崎和弘
    • Total Pages
      3
    • Publisher
      永井書店、大阪
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 脳の老化、生理学、高齢者で問題になる脳波、TMSによるアルツハイマー病患者の皮質の興奮性の充進. 「現代老年精神医療」(武田雅俊編)2005

    • Author(s)
      篠崎和弘, 郭哲次, 北端裕司
    • Total Pages
      8
    • Publisher
      永井書店、大阪
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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