Prediction of tumor response to chemoradiotherapyagainst esophageal cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 17591241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yamagata University (2006-2008); Tohoku University (2005)
• Principal Investigator: NEMOTO Kenji Yamagata University, 医学部, 教授 (10208291)
• Project Period (FY): 2005 – 2008
• Keywords: 食道癌 / 化学放射線療法 / 反応予測 / 免疫組織染色

Research Abstract

切除可能食道癌に対する化学放射線療法症例の免疫染色結果と予後、局所制御の関連につき検討を行った。Ki-67ラベリングインデックス高値(40%以上)、VEGF、uPA の染色性が低い症例では予化学放射線療法後の生存率も良好で、局所制御も高率に得られていた。今後、高率に局所制御が得られる症例では化学放射線療法を勧め、それ以外の症例で手術を勧めることにより、無駄な手術、無駄な化学放射線療法の施行を避けることができ、全体の予後の改善も可能になる。

Research Products

• [Journal Article] Comparison ofcisplatin and 5-fluorouracilchemotherapy protocols combined withconcurrent radiotherapy for esophagealcancer (2009)
  • Author(s): Sakayauchi T, Nemoto K, Ishioka C,Onishi H, Yamamoto M, Kazumoto T,Makino M, Yonekura R, Itami J, SasakiS, Suzuki G, Hayabuchi N, Tamamura H,Onimaru R, Yamada S.
  • Journal Title: Jpn J Radiol 27 Pages: 131-137
  • Peer Reviewed
• [Journal Article] Long-term results ofradiotherapy for T1a and T1bN0M0glottic carcinoma (2008)
  • Author(s): Nomiya T, Nemoto K, Wada H, Takai Y,Yamada S.
  • Journal Title: Laryngoscope 118 Pages: 1417-1421
  • Peer Reviewed
• [Journal Article] Efficacy of novel hypoxiccell sensitiser doranidazole in thetreatment of locally advancedpancreatic cancer Long-term resultsof a placebo-controlled randomisedstudy (2008)
  • Author(s): Karasawa K, Sunamura M, Okamoto A,Nemoto K, Matsuno S, Nishimura Y,Shibamoto Y.
  • Journal Title: Radiother Oncol 87 Pages: 326-330
  • Peer Reviewed
• [Journal Article] Carbon IonRadiation Therapy for Primary RenalCell Carcinoma Initial ClinicalExperience (2008)
  • Author(s): Nomiya T, Tsuji H, Hirasawa N, Kato H,Kamada T, Mizoe J, Kishi H, Kamura K,Wada H, Nemoto K, Tsujii H.
  • Journal Title: Int J Radiat Oncol BiolPhys 72(3) Pages: 828-33
  • Peer Reviewed
• [Journal Article] Prospective single-arm studyof 72 Gy hyperfractionated radiationtherapy and combination chemotherapyfor anaplastic astrocytomas (2008)
  • Author(s): Nomiya T, Nemoto K, Kumabe T, Takai Y,Yamada S.
  • Journal Title: BMC Cancer 16 Pages: 11
  • Peer Reviewed
• [Journal Article] A phase II study onstereotactic body radiotherapy forstage I non-small cell lung cancer (2007)
  • Author(s): Koto M, Takai Y, Ogawa Y, Matsushita H,Takeda K, Takahashi C, Britton KR,Jingu K, Takai K, Mitsuya M, Nemoto K,Yamada S
  • Journal Title: Radiother Oncol 85 Pages: 429-434
  • Peer Reviewed
• [Journal Article] A new Ncategory for cancer in theesophagogastric junction based onlymph node compartment (2007)
  • Author(s): Fujita H, Aiko T, Tsurumaru M, YoshidaM, Shimoda T, Kawano T, Udagawa H, OzawaS, Matsubara H, Nemoto K
  • Journal Title: Esophagus 4 Pages: 103-110
  • Peer Reviewed
• [Journal Article] Temporal Change in Brain NatriureticPeptide after Radiotherapy forThoracic Esophageal Cancer (2007)
  • Author(s): Jingu K, Nemoto K, Kaneta T, Oikawa M,Ogawa Y, Ariga H, Takeda K, SakayauchiT, Fujimoto K, Narazaki K, Takai Y,Nakata E, Fukuda H, Takahashi S, YamadaS.
  • Journal Title: Int JRadiat Oncol Biol Phys 69 Pages: 1417-23
  • Peer Reviewed
• [Journal Article] Prognostic significance ofsurgery and radiation therapy in casesof anaplastic astrocytoma retrospective analysis of 170 cases (2007)
  • Author(s): Nomiya T, Nemoto K, Kumabe T, Takai Y,Yamada S.
  • Journal Title: J Neurosurg 106 Pages: 575-581
  • Peer Reviewed
• [Journal Article] Chemoradiotherapy for a patient with agiant esophageal fistula (2007)
  • Author(s): Nomiya T, Teruyama K, Wada H, Nemoto K.
  • Journal Title: World J Gastroenterol 13 Pages: 2250-2254
  • Peer Reviewed
• [Journal Article] Phase I trial of concurrentchemoradiation with weekly nedaplatinin patients with squamous cellcarcinoma of the uterine cervix (2007)
  • Author(s): Yoshinaga K, Niikura H, Ogawa Y, NemotoK, Nagase S, Takano T, Ito K, Yaegashi N.
  • Journal Title: Gynecol Oncol 104 Pages: 36-40
  • Peer Reviewed
• [Journal Article] Dose escalationstudy of docetaxel and nedaplatin inpatients with relapsed or refractorysquamous cell carcinoma of theesophagus pretreated using cisplatin,5-fluorouracil, and radiation (2006)
  • Author(s): Yoshioka T, Sakayori M, Kato S, ChibaN, Miyazaki S, Nemoto K, Shibata H,Shimodaira H, Ohtsuka K, Kakudo Y,Sakata Y, Ishioka C.
  • Journal Title: Int J Clin Oncol 11 Pages: 454-460
  • Peer Reviewed
• [Journal Article] The utility of18F-fluorodeoxyglucose positronemission tomography for earlydiagnosis of radiation-inducedmyocardial damage (2006)
  • Author(s): Jingu K, Kaneta T, Nemoto K, IchinoseA, Oikawa M, Takai Y, Ogawa Y, NakataE, Sakayauchi T, Takai K, Sugawara T,Narazaki K, Fukuda H, Takahashi S,Yamada S
  • Journal Title: Int J Radiat Oncol Biol Phys 66 Pages: 845-851
  • Peer Reviewed
• [Journal Article] Prospective trial ofradiotherapy for patients 80 years ofage or older with squamous cellcarcinoma of the thoracic esophagus (2006)
  • Author(s): Kawashima M, Kagami Y, Toita T, Uno T,Sugiyama M, Tamura Y, Hirota S, Fuwa N,Hashimoto M, Yoshida H, Shikama N,Kataoka M, Akuta K, Sasaki K, TamamotoT, Nemoto K, Ito H, Kato H, Yamada S,Ikeda H
  • Journal Title: Int J Radiat Oncol Biol Phys 64 Pages: 1112-1121
  • Peer Reviewed
• [Journal Article] Resultsof radiation therapy combined withnedaplatin (cis-diammine-glycoplatinum) and 5-Fluorouracil for postoperativelocoregional recurrent esophagealcancer (2006)
  • Author(s): Jingu K, Nemoto K, Matsushita H,Takahashi C, Ogawa Y, Sugawara T,Nakata E, Takai Y, Yamada S
  • Journal Title: BMC Cancer 6 Pages: 50
  • Peer Reviewed
• [Journal Article] Predictive factorsfor acute esophageal toxicity inthoracic radiotherapy (2006)
  • Author(s): Takeda K, Nemoto K, Saito H, Ogawa Y,Takai Y, Yamada S
  • Journal Title: Tohoku J Exp Med 20 Pages: 299-306
  • Peer Reviewed
• [Journal Article] Advantage of acceleratedfractionation regimens in definitiveradiotherapy for stage II glotticcarcinoma (2006)
  • Author(s): Nomiya T, Nemoto K, Wada H, Takai Y,Yamada S
  • Journal Title: Ann Otol Rhinol Laryngol 115 Pages: 727-732
  • Peer Reviewed
• [Journal Article] Results of radiationtherapy for superficial esophagealcancer using standard radiotherapymethod recommended by Japanese Society of Therapeutic Radiology and Oncology (JASTRO)study group (2006)
  • Author(s): Nemoto K, Yamada S, Nishio M, Aoki M,Nakamura R, Matsumoto Y, Sasamoto R,Saito Y, Takayama M, Mitsuhashi N, GomiK, Kanesaka N, Kobayashi M, Ohnishi H,Sasaki S, Tamamura H, Mitsumori M,Nishimura Y, Tsujino K, Takemoto M,Uchida N, Yamamoto M, Shioyama Y,Hirakawa K, Ono S
  • Journal Title: Anti Cancer Res. 26 Pages: 1507-1512
  • Peer Reviewed
• [Journal Article] Expression of thymidinephosphorylase and VEGF in esophageal squamous cell carcinoma (2006)
  • Author(s): Nomiya T, Nemoto K, Nakata E, Takai Y,Yamada S
  • Journal Title: Oncol Rep. 15 Pages: 1497-1501
  • Peer Reviewed
• [Journal Article] S-1, an oralfluoropyrimidine, enhances radiation response of DLD-1/FU human colon cancerxenografts resistant to 5-FU (2006)
  • Author(s): Nakata E, Fukushima M, Takai Y, NemotoK, Ogawa Y, Nomiya T, Nakamura Y, MilasL, Yamada S
  • Journal Title: Oncol Rep 16 Pages: 465-471
  • Peer Reviewed
• [Journal Article] The utility of(18)F-fluorodeoxyglucose positronemission tomography for earlydiagnosis of radiation-inducedmyocardial damage (2006)
  • Author(s): Jingu K, Kaneta T, Nemoto K, IchinoseA, Oikawa M, Takai Y, Ogawa Y, NakataE, Sakayauchi T, Takai K, Sugawara T,Narazaki K, Fukuda H, Takahashi S,Yamada S.
  • Journal Title: Int J Radiat OncolBiol Phys. 66 Pages: 845-51
  • Peer Reviewed
• [Presentation] Prospective Comparison of Outcome and Post-treatment Quality ofLife in Patients with Operable ThoracicEsophageal Cancer ReceivingChemoradiotherapy and PatientsUndergoing Surgery (2008)
  • Author(s): Nemoto K, Ariga H, Yamada S, Onodera K,Satomi S.
  • Organizer: The 21st International Symposium Modern Radiation Oncology InnovativeTechnologies And Translational Research Foundation
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-20
• [Presentation] Chemoradiationtherapy for resectable esophagealcancer, survival and quality of life (2006)
  • Author(s): Nemoto K, Ariga H
  • Organizer: 5th Japan-US cancer symposium
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2006-09-07
• [Presentation] Results ofradiation therapy for superficialesophageal cancer using standardradiotherapy method recommended byJapanese Society of TherapeuticRadiology and Oncology(JASTRO)studygroup (2005)
  • Author(s): Nemoto K. Yamada S, Mistuhashi N, GomiK, Nishio M, Yamamoto M, Shioyama Y,Tsujino M, Mitsumori M, Nishimura Y,Nakamura R, Matsumoto Y.
  • Organizer: 47th ASTRO meeting
  • Place of Presentation: Denver, CO
  • Year and Date: 20051016-19
• [Book] 食道がん。化学放射線療法プラクティカルガイド (2009)
  • Author(s): 根本建二、野宮琢磨、和田仁
  • Total Pages: 171-179
  • Publisher: 南山堂
• [Book] 食道癌. 放射線治療計画ガイドライン2008 (2008)
  • Author(s): 根本建二
  • Total Pages: 157-163
  • Publisher: メディカル教育研究社
• [Book] 放射線治療の対象となる腫瘍とその病期. セカンドオピニオン実践ガイド (2007)
  • Author(s): 根本建二、山田章吾
  • Total Pages: 68-72
  • Publisher: 文光堂