2007 Fiscal Year Final Research Report Summary
The bystander effect observed in boron neutron capture therapy
| Project/Area Number |
17591266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KINASHI Yuko Kyoto University, Research Reactor Institute, Assistant Professor (80252534)
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| Project Period (FY) |
2005 – 2007
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| Keywords | micronucleus / lymphocyte / boron neutron capture therapy / acute radiation effect / α粒子 |
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| Research Abstract |
Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy
(1) A comparison with thyroid cancer patients treated with radioiodine
This study evaluated micronuclei induction in peripheral T-lymphocytes after BNCT (boron neutron capture therapy) irradiation of brain tumor and head-and-neck cancer patients. In all of these patients, the micronucleus frequency increased after BNCT; the number of micronuclei per 1000 binucleated T-lymphocytes after BNCT increased by 33.0±12.2 for brain tumor patients and 22.8±10.3 for head-and-neck cancer patients. In comparison to 14 thyroid cancer patients administered radioiodine (3.3-5.6 GBq) treatment, the frequency of micronuclei after internal radioiodine therapy increased to 105.0±30.5 per 1000 binucleated T-lymphocytes for thyroid cancer patients; thereafter, the increased micronucleus frequency of BNCT patients was less than one-third that seen for thyroid cancer patients after radioiodine treatment
(2) A comparison with X-ray radiotherapy
The evidence of acute radiation effect was studied based on a questionnaire answered by the chief physician. In an in-vitro neutron radiation study, we observed standard dose-response model induction and calculated the maximal biological dose estimation as 0.24 Gy-eq for head and neck tumor patients and 0.20 Gy-eq for brain tumor patients. The total body radiation dose obtained by biological estimation using the micronucleus assay correlated with the total effective dose of BNCT obtained by thermal neutron fluence and TLD estimation. The increased micronucleus frequency in BNCT patients was less than one-third of that in malignant tumor patients after X-ray radiotherapy.
These findings (1 and 2) demonstrate the usefulness of BNCT for selective high-LET radiotherapy, in association with a low irradiation effect of cytological radiation damage after BNCT, which provides a high tumor target dose for each cancer patient.
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[Journal Article] Radiobiologic significance of response of intratumor quiescent cells to accelated carbon ion beams compared with gamma-rays and reactor neutron beams2008
Author(s)
S. Masunaga, K Ando, A Uzawa, R Hirayama, Y Furusawa, S Koike, Y Sakurai, K. Nagata, M. Suzuki, G. Kashino, Y. Kinashi, H Tanaka, A Maruhashi and K. Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 70
Pages: 221-228
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Biological dosimetry using micronucleus assay of lymphocytes for BNCT patients2008
Author(s)
Y., Kinashi, Y., Sakurai, S., Masunaga, M., Suzuki, K., Nagata, K., Ono
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Journal Title
J.Jpn.Soc.Ther.Radiol.Oncol 20
Pages: 23-28
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Radiobiologic significance of response of intratumor quiescent cells to accelated carbon ion beams compared with gamma-rays and reactor neutron beams2008
Author(s)
S., Masunaga, K., Ando, A., Uzawa, R., Hirayama, Y., Furusawa, S., Koike, Y., Sakurai, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, H., Tanaka, A., Maruhashi, K.,Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 70
Pages: 221-228
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells.2007
Author(s)
Kashino G, Prise KM, Suzuki K, Matsuda N, Kodama S, Suzuki M, Nagata K, Kinashi Y, Masunaga S, Ono K, Watanabe M.
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Journal Title
Journal of Radiation Research 48
Pages: 327-333
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] The bystandar effect observed in boron neutron capture therapy : a study of the induction of mutations in the HPRT locus2007
Author(s)
Y., Kinashi, S., Masunaga, M., Suzuki, K., Nagata, S., Takahashi, K., Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 68
Pages: 508-514
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy : A comparison with thyroid cancer patients treated with radioiodine2007
Author(s)
Y., Kinashi, S., Masunaga, Y., Sakurai, M., Suzuki, K., Nagata, K., Ono
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Journal Title
Journal of Radiation Research 48
Pages: 197-204
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Dependency of rapair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treated in vivo, with reference to the effect on intratumor quescent cell popuration2007
Author(s)
S., Masunaga, A., Takahashi, K., Ohnishi, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, T., Ohnishi, K., Ono
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Journal Title
Oncology Reports 18
Pages: 1589-1596
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Inhibition of repair if radiation-induced damage by mild temperature hyperthermia, reffering to the effect on quiescent cell popurations2007
Author(s)
S., Masunaga, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, H., Tanaka, A., Maruhashi, K., Ono
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Journal Title
Radiation Medicine 25
Pages: 417-425
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells2007
Author(s)
Kashino, G., Prise KM., Suzuki, K., Matsuda, N., Kodama, S., Suzuki, M., Nagata, K., Kinashi, Y., Masunaga, S., Ono, K., Watanabe, M
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Journal Title
Journal of Radiation Research 48
Pages: 327-333
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma A preliminary experimental study of boron neutron capture therapy for malignant tumors sreading in thoracic cavity2007
Author(s)
M., Suzuki, Y., Sakurai, S., Hagiwara, S., Masunaga, Y., Kinashi, K., Nagata, A., Maruhashi, M., Kudo, K., Ono
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Journal Title
Japanese Journal of Clinical Oncology 37
Pages: 376-381
Description
「研究成果報告書概要(欧文)」より
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