Development of prostate MR spectra analysis at high magnetic field for the purpose of evaluation of tumor aggressiveness

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17591267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Dokkyo Medical University (2006); Kobe University (2005)
• Principal Investigator: KAJI Yasushi Dokkyo Medical University, School of Medicine, Professor, 医学部, 教授 (10273947)
• Co-Investigator(Kenkyū-buntansha): SUGIMURA Kazuro Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (00136384) ; FUJII Masahiko Kobe University, Graduate School of Medicine, Associate Professor, 医学部附属病院, 助教授 (00228959) ; FUJISAWA Masato Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (30243314) ; KURODA Kagayaki Tokai University, Faculty of Information and Electronics, Associate Professor, 電子情報学部, 助教授 (70205243)
• Project Period (FY): 2005 – 2006
• Keywords: prostate cancer / citrate / MR spectroscopy

Research Abstract

80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.
Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.