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2006 Fiscal Year Final Research Report Summary

Development of prostate MR spectra analysis at high magnetic field for the purpose of evaluation of tumor aggressiveness

Research Project

Project/Area Number 17591267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionDokkyo Medical University (2006)
Kobe University (2005)

Principal Investigator

KAJI Yasushi  Dokkyo Medical University, School of Medicine, Professor, 医学部, 教授 (10273947)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Kazuro  Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (00136384)
FUJII Masahiko  Kobe University, Graduate School of Medicine, Associate Professor, 医学部附属病院, 助教授 (00228959)
FUJISAWA Masato  Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (30243314)
KURODA Kagayaki  Tokai University, Faculty of Information and Electronics, Associate Professor, 電子情報学部, 助教授 (70205243)
Project Period (FY) 2005 – 2006
Keywordsprostate cancer / citrate / MR spectroscopy
Research Abstract

80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.
Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.

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Published: 2008-05-27  

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