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2006 Fiscal Year Final Research Report Summary

Visualization of Molecular Mechanism of Brain Function and Neurological Disease Using High Magnetic Field MRI

Research Project

Project/Area Number 17591275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokushima

Principal Investigator

HARADA Masafumi  The University of Tokushima, Faculty of Medicine, Professor, 医学部, 教授 (20228654)

Co-Investigator(Kenkyū-buntansha) KAJI Ryuuji  The University of Tokushima, Institute of Health Biosciences, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 (00214304)
UENO Syuuichi  The University of Tokushima, Faculty of Medicine, Professor, 医学部, 教授 (80232768)
KUBO Hitoshi  The University of Tokushima, Faculty of Medicine, Assoc.Professor, 医学部, 講師 (00325292)
Project Period (FY) 2005 – 2006
KeywordsMRS / GABA / NAA / MEGA-PRESS / SPECT
Research Abstract

Gamma-aminobutyric acid (GABA) in normal subjects and patients was measured using MEGA-PRESS on clinical 3T MR apparatus and the GABAnergic index was proposed. The result of GABA nergic index was compared with the data of receptor scintigraphy in the autistic patients.
Ten autistic patients (2〜11 y.o., mean 5.2 y.o.) were measured by routine anatomical MRI and after obtaining informed consents from their parents, single voxel proton MRS including MEGA-PRESS was conducted. As age-matched normal controls, six children (3〜12 y.o., mean 6.6 y.o.) who show no neurological abnormality and anatomical disorder in the brain by MRI were recruited after getting informed consents. The measured locations were left frontal lobe and left basal ganglia. The in-vitro data of NAA, Glutamine, Glutamate and GABA were acquired by MEGA-PRESS and set as a basis-set for LCModel. The quantification of signals in the difference and original spectrum by MEGA-PRESS were conducted by LCModel. A new parameter for GABAnergic neurons was defined as followed: GABAnergic index=(GABA signal from a subtracted spectra divided by NAA signal from the original spectra without selective pulses).
The result of GABAnergic index in the frontal lobe and basal ganglia and this index in the frontal lobe on autistic patients were lower than that on normal controls (p<0.05). However, there is no difference in the basal ganglia between autism and normal controls. An example of the receptor scintigraphy (iomazenil SPECT) showed the activity ratio of the frontal lobe/cerebellum in autism was lower than that of the normal controls. This finding on the receptor scintigraphy was almost consistent with the result of GABAnergic index, suggesting the decrease of GABAnergic activity in the frontal lobe on autistic patients.
The GABAnergic index calculated from MEGA-PRESS data would be useful for the evaluation of neurochemical disorder on autistic patients.

  • Research Products

    (9 results)

All 2007 2006 2005

All Journal Article (8 results) Book (1 results)

  • [Journal Article] Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of OCD patients.2007

    • Author(s)
      Sumitani S
    • Journal Title

      Psychiatry Research Neuroimaging 154

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of OCD patients.2007

    • Author(s)
      Sumitani S, Harada M, et al.
    • Journal Title

      Psychiatry Research Neuroimaging 154

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 中枢神経のMRI-脳機能や代謝の評価を中心に-2006

    • Author(s)
      原田雅史
    • Journal Title

      映像情報Medical 37・14

      Pages: 44-50

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 3 Tesla MRI装置による中枢神経のMRI, MRS2006

    • Author(s)
      原田雅史
    • Journal Title

      Radiology Frontier 08・04

      Pages: 156-157

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 脳血管障害におけるMRSの有用性2006

    • Author(s)
      原田雅史
    • Journal Title

      臨床画像 22・4

      Pages: 76-84

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] MR spectroscopy2006

    • Author(s)
      原田雅史
    • Journal Title

      Clinical Neuroscience 24・4

      Pages: 443-446

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cerebral hyperperfusion in a patient with eclampsia with perfusion-weighted magnetic resonance imaging.2005

    • Author(s)
      Takeuchi M
    • Journal Title

      Radiation Medicine 23・5

      Pages: 376-379

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cerebral hyperperfusion in a patient with eclampsia with perfusion-weighted magnetic resonance imaging2005

    • Author(s)
      Takeuchi M, Harada M, et al.
    • Journal Title

      Radiation Medicine 23

      Pages: 376-379

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 脳神経外科学大系第2巻検査・診断法MRS2006

    • Author(s)
      原田雅史
    • Total Pages
      9
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

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