2007 Fiscal Year Final Research Report Summary
Development of a new diagnostic method for early Alzheimer's disease using brain perfusion SPECT and numerical analysis
| Project/Area Number |
17591313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute for Longevity Sciences,NCGG |
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Principal Investigator |
ITO Kengo National Institute for Longevity Sciences,NCGG, National Center for Geriatrics and Gerontology Department of Brain Sciences and Molecular Imaging, Department Head (70184653)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi National Center for Geriatrics and Gerontology, Department of Brain Sciences and Molecular Imaging Section of Brain Pathophysiology, Section Chief (60242864)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Alzheimer's disease / early diagnosis / SPECT / numerical analysis |
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| Research Abstract |
To achieve a higher diagnostic performance of brain perfusion SPECT for Alzheimer's disease(AD) a new method, voxel based weighted factor analysis(VBWFA), has been developed based on multivariate analysis and then clinically validated in mild cognitive impairment(MCI) cases. Methods : ^123I-IMP brain perfusion SPECT data were processed using 3D-SSP in 19 normal controls(NC) and 12 AD patients, and then the factor analysis of surface projection images with global mean normalization was performed. After extracting factor score images suggesting AD characteristics, factor scores were weighted to optimize the differentiation between NC and AD and the sum of squares was considered as the score of each case. Using these data as a basic data set, numerical diagnosis was performed in 25 MCI patients. The results of numerical diagnosis were compared with image diagnosis of SPECT by visual interpretation in all cases and with clinical outcomes in 10 cases. Results : Factor analysis of the data set of NC and AD revealed factor score images reflecting the changes of cerebral blood flow in the posterior cingulate gyri/precunei, parietotemporal association area, medial temporal area, and frontal base. Factor score for each MCI case was distributed randomly between NC and AD. The results of numerical diagnosis were in agreement with image diagnosis in 21 of the 25 cases and with clinical outcomes in 8 of the 10 cases. Conclusion : The VBWFA based on multivariate analysis can extract image characteristics of AD and would be useful for early diagnosis of AD at MCI stage.
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Research Products
(27 results)
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[Journal Article] Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients2007
Author(s)
Nihashi T, Yatsuya H, Hayasaka K, Kato R, Kawatsu S, Arahata Y, Iwai K, Takeda A, Washimi Y, Yoshimura K, Mizuno K, Kato T, Naganawa S, Ito K
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Journal Title
Radiat Med 25
Pages: 255-262
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Presentation] A numerical diagnostic method of alzheimer's disease with imp-spect and automated gyral rois2005
Author(s)
Yoshimura K, Kato T, Nihashi T, Abe Y, Arahata Y, Iwai K, Takeda A, Tanaka I, Kato R, Kawatsu S, Nakamura A, Kachi T, Washimi Y, Ito K
Organizer
Society of Nuclear Medicine, 52nd Annual Meeting
Place of Presentation
カナダ
Year and Date
20050618-22
Description
「研究成果報告書概要(和文)」より
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[Presentation] A numerical diagnostic method of alzheimer's disease with imp-spect and automated gyral rois2005
Author(s)
Yoshimura K, Kato T, Nihashi T, Abe Y, Arahata Y, Iwai K, Takeda A, Tanaka I, Kato R, Kawatsu S, Nakamura A, Kachi T, Washimi Y, Ito K
Organizer
Society of Nuclear Medicine, 52nd Annual Meeting
Place of Presentation
Canada
Year and Date
20050618-22
Description
「研究成果報告書概要(欧文)」より
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