2006 Fiscal Year Final Research Report Summary
Basic research of bone marrow cells for liver regeneration, fibrogenesis, and carcinogenesis
| Project/Area Number |
17591316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
INAGAKI Mitsuhiro Asahikawa Medical College, Department of Surgery, assistant professor, 医学部, 講師 (80261410)
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| Co-Investigator(Kenkyū-buntansha) |
KASAI Shinichi Asahikawa Medical College, Dept.of Surgery, professor, 医学部, 教授 (40091566)
OGAWA Katsuhiro Asahikawa Medical College, Dept.of Pathology, professor, 医学部, 教授 (50045514)
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| Project Period (FY) |
2005 – 2006
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| Keywords | bone marrow cells / pheripheral blood cell / G-CSF / analbuminemic rat / 70% partial hepatectomy / PCR / microdissection / in situ hybridization |
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| Research Abstract |
We investigated whether bone marrow cells (BMCs) of normal rats (F344) can raise albumin-producing hepatocytes in analbuminemic rat (F344a1b) livers. (J.Arikura, M.Inagaki et al. Journal of Hepatology 41;215-221,2004.X.Huiling, M. Inagaki et al. Journal of Surgical Research 122 (1) ; 75-82,2004)
In this project, we got the following results using the F344a1b.
Experiment 1 Cryopreserved BMCs can induce the growth of alb+ hepatocytes after transplantation in the F344alb liver after 70% partial hepatectomy. (M. Inagaki et al. Surgery Today 35;955-960,2005) Experiment 2 F344 rat liver nonparenchymal cell transplantation can increase the number of Alb+ hepatocytes in the liver following hematopoietic reconstitution in irradiated F344alb. (European Surgical Research 38;533-539,2006)
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