2007 Fiscal Year Final Research Report Summary
The relationship between gender-related diffrenoe in immune response and DHEA following surgical stress
| Project/Area Number |
17591356
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
MATSUTANI Takeshi Nippon Medical School, Faculty of Medicine, Assistant Professor (50366712)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SASAJIMA Koji Nippon Medical School, Faculty of Medicine, Professor (80158930)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Keywords | gender difference related treatment / surgical stress / modulation of host response |
|---|
| Research Abstract |
Object : To determine whether gender differences are observed in circulating sex hormone and inflammatory cytokine levels following major surgery.
Method : Twenty-nine patients (male ; n = 21, female ; n = 8) who underwent gastrectomy for gastric cancer, 42 patients (male ; n = 26, female ; n = 16) who underwent colorectal surgery for colorectal cancer, and 21 patients (male ; n = 17, female ; n = 4) who underwent thoracic-abdominal surgery for esophageal cancer were measured the circulating 17β-estradial, testosterone, DHEA and inflammatory cytokines.
Results : The percentage of patients in female group who had severe complications was significantly lower than the corresponding percentage of the male group. Inflammatory cytokines and CRP levels in male group increased significantly compared to the female group. The 17β-estradiol-to-testostrone ratio in the postoperative complication of male group was significantly higher in the control male group. There were no differences in DHEA levels between the postoperative complication and control groups in male.
After surgery, the circulating adiponectin levels decreased and leptin levels increased. The alteration of adiponectin and leptin levels were significantly correlated with the 17β-estradiol-to-testostrone ratio and testosterone levels.
Conclusion : Our data revealed that the adipocyte dysfunction under the regulation of sex hormones might develop postoperative complications after major surgery.
These results were already presented in the surgical-related meeting. Two original papers "Depressed adipocyte function is a risk factor for postoperative infection following colorectal cancer surgery" and "Gender-related difference in immune responses following major surgical trauma are diminished by preoperative steroid administration" were submitted.
|
Research Products
(37 results)
-
-
-
[Journal Article] Liver cytoldne production and ICAM-1 expression following bone Fracture, tissue trauma, and hemorrhage in middle-aged mice2007
Author(s)
Matsutani, T., Kang, SC., Miyashita, M., Sasajima, K., Choudhry, MA., Bland, KL., Chaudry, IH
-
Journal Title
American Journal of Physiology-Gastrointestinal and Liver Physiology 292
Pages: G268-G274
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Young and middle-aged associated difference in cytokeratin expression After bone fracture, tissue trauma, and hemorrhage2007
Author(s)
Matsutani, T., Kang, SC., Miyashita, M., Sasajima, K., Choudhry, MA., Bland, KL., Chaudry, IH
-
Journal Title
American Journal of Surgery 193
Pages: 61-68
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] The relationship between inflammatory response in the tissue and aged factor following mice trauma-hemorrhage (in Japanese)2007
Author(s)
Matsutani, T., Sasajima, K., Maruyama, H., Matsuda, A., Miyamoto, M., Yokoyama, T., Suzuki, S., Kashiwabara, M., Miyashita, M., Tajiri, T., Chaudry, IH
-
Journal Title
The Japan Shock Society 21
Pages: 61-66
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Journal Article] Dehydroepiandtrosterone modulates tool-like receptor expression on Splenic macrophages of mice after severe polymicrobial sepsis2005
Author(s)
Matsuda, A., Furukawa, K., Suzuki, H., Matsutani, T., Tajiri, T., Chadury, IH
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
