2007 Fiscal Year Final Research Report Summary
Clinical research of adjuvant chemotherapy to prevent recurrence after surgical resection for liver metastasis from colorectal cancer
Project/Area Number |
17591377
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
KOKUDO Norihiro The University of Tokyo, The Tokyo University Hospital, Professor (00205361)
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Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Kiyoshi The Tokyo University, Hospital, Lecturer (20292906)
YAMAMOTO Junji The Cancer Institute Hospital, Department of Digestive Surgery, Chief (40342654)
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Project Period (FY) |
2005 – 2007
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Keywords | Cancer / Surgery / Chemotherapy / Metastasis |
Research Abstract |
The first aim of this clinical research is to investigate whether oral adjuvant chemotherapy using calcium folinate and tegafur uracil can decrease recurrence rate in patients undergoing surgical resection for liver metastasis from colorectal cancer. The second aim is to investigate the clinical effects of this adjuvant chemotherapy on prognosis by measuring mRNA level of TS (thymidylate synthase), TP (thymidine phosphorylase), DPD (dihydropyrimidine dehydrogenase), and OPRT (orotate phosphoribosyltrasferase) in the resected cancerous tissue. Between February 2004 and March 2008, total 110 patients have been registered. Registration of 70 patients is needed to the goal. The study period was set until the end of 2008, however, we extend the period until the end of 2009, because the pace of registration has been promoted and achievement of the goal is important to obtain some scientific conclusion in this trial. This extension of the study period was determined in the annual meeting held in April8 2008 in Tokyo. Although the registration pace is slower than was expected, the achievement of the goal is at last in sight. For the second aim, we have gathered the resected specimen of all registered patients, and will measure mRNA level (TS, TP, DPD, OPRT) after the achievement of the goal. We will register 180 patients (goal) until the end of 2009, and follow them up for at least 3 years. The results of this study will be acknowledged to the public in domestic and international meetings, and will be published in some English peer-reviewed journals. During the term of project, we discussed the practical problems about the registration of RCT in a short letter, which was published in Journal of Clinical Oncology (2007; 25:1299-1300). In addition, we have done presentation in scientific meetings and published articles concerning surgical treatment for primary and metastatic liver carcinomas.
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Research Products
(363 results)
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[Journal Article] KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma2007
Author(s)
Wei Tang, Qian Guo, Xianjun Qu, Yoshinori Inagaki, Yasuji Seyama, Yutaka Midorikawa, Ruoyan Gai, Norihiro Kokudo, Yasuhiko Sugawara, Munehiro Nakata, Masatoshi Makuuchi
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Journal Title
Oncol Rep 17
Pages: 737-741
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 肝臓手術と膵臓手術における特殊縫合糸使用実態に関する多施設調査-医療経済面からの考察2007
Author(s)
國土典宏, 兼松隆之, 炭山嘉伸, 中田精三, 島田光生, 樫村暢一, 磯部陽, 平田哲, 山口俊晴, 松山裕, 杉浦伸一, 出月康夫
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Journal Title
日本臨床外科学会雑誌 68(5)
Pages: 1077-1081
Description
「研究成果報告書概要(和文)」より
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[Journal Article] KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma2007
Author(s)
Wei Tang, Qian Guo, Xianjun Qu, Yoshinori Inagaki, Yasuji Seyama, Yutaka Midorikawa, Ruoyan Gai, Norihriro Kokudo, Yasuhiko Sugawara, Munehiro Nakata, Masatoshi Makuuchi
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Journal Title
Oncol Rep 17
Pages: 737-741
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clinical significance of subcellular Iocalization of KL-6 mucin in primary colorectal adenocarcinoma and the metastatic tissues.2006
Author(s)
Qian Guo, Wei Tang, Yoshinori Inagaki, Yutaka Midorikawa, Norihiro K, okudo, Yasuhiko Sugawara, Munehiro Nakata, Toshiro Konishi, Hirokazu Nagawa, Masatoshi Makuuchi
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Journal Title
World J Gastroenterol 12(1)
Pages: 54-59
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Endoscopic Management of Biliary Complications after Adult Living Donor Liver Transplantation2006
Author(s)
Takeshi Tsujino, Hiroyuki Isayama, Yasuhiko Sugawara, Takashi Sasaki, Hirofumi, Kogure, Yousuke Nakai, Natsuyo Yamamoto, Naoki Sasahira, Noriyo Yamashiki, Minoru Tada, Haruhiko Yoshida, Norihiro Kokudo, Takao Kawabe, Masatoshi Makuuchi, Masao Omata
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Journal Title
Am J Gastroenterol 101
Pages: 2230-2236
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Avoiding Pandemic Influenza: Improvements and Concerns in China s Public Health System2006
Author(s)
Ruoyan Gai, Jinxiang Han, Yong Huang, Qingqiang Yao, Xianjun Qu, Munehiro Nakata, Norihiro Kokudo, Yasuhiko Sugawara, Masatoshi Makuuchi, Chushi Kuroiwa, Wwi Tang
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Journal Title
Journal of Health Care and Society 16(1)
Pages: 139-150
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Endoscopic Management of Biliary Complications after Adult Living Donor Liver Transplantation2006
Author(s)
Takeshi Tsujino, Hiroyuki Isayama, Yasuhiko Sugawara, Takashi Sasaki, Hirofumi, Kogure, Yousuke Nakai, Natsuyo Yamamoto, Naoki Sasahira, Noriyo Yamashiki, Minoru Tada, Haruhiko Yoshida, Noribriro Kokudo, Takao Kawabe, Masatoshi Makuuchi, Masao Omata
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Journal Title
Am J Gastroenterol 101
Pages: 2230-2236
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Avoiding Pandemic Influenza : Improvements and Concerns in China s Public Health System2006
Author(s)
Ruoyan Gai, Jinxiang Han, Yong Huang, Qinggiang Yao, Xianjun Qu, Munehiro Nakata, Norihriro Kokudo, Yasuhiko Sugawara, Masatoshi Makuuchi, Chushi Kuroiwa, Wwi Tang
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Journal Title
Journal of Health Care and Society 16(1)
Pages: 139-150
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Hepatitic C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression2005
Author(s)
Hideyuki Miyoshi, Hajime Fujie, Yoshizumi Shintani, Takeya Tsutsumi, Seiko Shinzawa, Masatoshi Makuuchi, Norihiro Kokudo, Yoshiharu Matsuura, Tetsuro Suzuki, Tatsuo Miyamura, Kyoji Moriya, Kazuhiko Koike
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Journal Title
J Hepatol 43
Pages: 757-763
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling(SOCS)-1 gene expression2005
Author(s)
Hideyuki Miyoshi, Hajime Fujie, Yoshizumi Shintani, Takeya Tsutsumi, Seiko Shinzawa, Masatoshi Makuuchi, Norihriro Kokudo, Yoshiharu Matsuura, Tetsuro Suzuki, Tatsuo Miyamura, Kyoji Moriya, Kazuhiko Koike
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Journal Title
J Hepatol 43
Pages: 757-763
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Liver resection for multiple hepatocellular carcinoma2007
Author(s)
Takeshi Ishizawa, Kiyoshi Hasegawa, Keiji Sano, Hiroshi Imamura, Yoshi fumi Beck, Yasuhiko Sugawara, Norihiro Kokudo, Masatoshi Makuuchi
Organizer
17th Asian Pacific Association for the Study of the liver(APASL)Conference
Place of Presentation
Kyoto
Year and Date
20070327-30
Description
「研究成果報告書概要(和文)」より
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[Presentation] Liver resection for multiple hepatocellular carcinoma2007
Author(s)
Takeshi Ishizawa, Kiyoshi Hasegawa, Keiji Sano, Hiroshi Imamura, Yoshifumi Beck, Yasuhiko Sugawara, Norihriro Kokudo, Masatoshi Makuuchi
Organizer
17th Asian Pacific Association for the Study of the liver(APASL) Conference
Place of Presentation
Kyoto
Year and Date
20070327-30
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 肝門部悪性リンパ腫の1切除例2007
Author(s)
大道清彦、青木琢、國土典宏、高本健史
Organizer
第295回日本消化器病学会関東支部例会、
Place of Presentation
海運クラブ
Year and Date
2007-07-07
Description
「研究成果報告書概要(和文)」より
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[Presentation] Repeat Hepatic Resection for Remnant Liver Recurrence of Hepatic Colorectal Cancer Metastases2006
Author(s)
Norihriro Kokudo, Hiroshi Imamura, Yasuji Seyama, Daisho Endo, Takuya Hashimoto, Masami Minagawa, Yoshifumi Beck, Keiji Sano, Yasuhiko Sugawara, Masatoshi Makuuchi
Organizer
16th World Congress of the International Association of Surgeons and Gastroenterologists, State-of-the-Art New Frontiers in Liver Surgery
Place of Presentation
Madrid
Year and Date
20060522-27
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 診断に苦慮した膵島細胞腫瘍の一例2006
Author(s)
有田淳一 國土典宏 伊佐山浩道 幕内雅敏
Organizer
第1回神経内分泌腫瘍における診断と治療について
Place of Presentation
東京ドームホテル
Year and Date
2006-10-03
Description
「研究成果報告書概要(和文)」より
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[Presentation] 肝移植後ノカルジア症の1例2005
Author(s)
佐野圭二、菅原寧彦、辛 宣廣、國土典宏、幕内雅敏
Organizer
第2回東京消化器外科感染症研究会
Place of Presentation
東京
Year and Date
2005-06-18
Description
「研究成果報告書概要(和文)」より
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