2006 Fiscal Year Final Research Report Summary
Molecular Diagnosis of colorectal cancer using preoperative endoscopic biopsies with clinical DNA chip
| Project/Area Number |
17591396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
TAKEMASA Ichiro Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (50379252)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hirofumi Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (30322184)
IKEDA Masataka 0saka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (80335356)
SEKIMOTO Mitsugu Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10273658)
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| Project Period (FY) |
2005 – 2006
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| Keywords | colorectal cancer / DNA chip / gene expression profile / molecular diagnostic system / endoscopic biopsy |
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| Research Abstract |
The aim of this study is to establish the preoperative molecular diagnostic system for colorectal cancer using endoscopic biopsies and to apply the system into clinic with the improvement of technical and financial problems in cDNA microarray. We had established the molecular diagnostic system for the prognosis of colorectal cancer with 30K human whole gene DNA chip using 200 surgical resected specimens, and we also identified the key genes related to the metastasis and recurrence.
With the results provided, we had revealed following two important knowledge related to gene expression profile of colorectal cancer; there is smaller difference of inter-tumor genetic heterogeneity than that of intra-tumor genetic heterogeneity, and so we can obtain representative gene expression profile using only one endoscopic biopsy. And we can distinguish colorectal adenoma and cancer from intact colorectal mucosa with our diagnostic system.
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[Journal Article] Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer.2006
Author(s)
Gu J., Yamamoto H., Ogawa M., Ngan C.Y., Danno K., Hemmi H., Kyo N., Takemasa I., Ikeda M., Sekimoto M., Monden M.
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Journal Title
Oncol Rep. 15(4)
Pages: 779-783
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma : a new approach to identify novel tumor markers.2006
Author(s)
Kurokawa Y., Honma K., Takemasa I., Nakamori S., Kita-Matsuo H., Motoori M, Nagano H, Dono K, Ochiya T., Monden M, Kato K.
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Journal Title
Int J Oncol. 28(2)
Pages: 383-391
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway.2006
Author(s)
Seki Y, Yamamoto H, Yee Ngan C, Yasui M, Tomita N, Kitani K, Takemasa I, Ikeda M, Sekimoto M, Matsuura N, Albanese C, Kaneda Y, Pestell RG, Monden M.
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Journal Title
Mol Cancer Ther. 5(4)
Pages: 985-994
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Antisense to cyclin DI inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells : implication of tumor vascularization.2006
Author(s)
Yasui M, Yamamoto H., Ngan CY., Damdinsuren B., Sugita Y., Fukunaga H., Gu J., Maeda M., Takemasa I., Ikeda M., Fujio Y, Sekimoto M., Matsuura N., Weinstein IB., Monden M.
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Journal Title
Clin Cancer Res. 12(15)
Pages: 4720-4729
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prediction of peritoneal metastasis in advanced gastric cancer by gene expression profiling of the primary site.2006
Author(s)
Motoori M., Takemasa I., Doki Y., Saito S., Miyata H., Takiguchi S., Fujiwara Y, Yasuda T., Yano M., Kurokawa Y., Komori T., Yamasaki M., Ueno N., Oba S., Ishii S., Monden M., Kato K.
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Journal Title
Eur J Cancer 42
Pages: 1897-1903
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression and Mutation of SMAD4 in poorly Differentiated Carcinoma and Signet-ring Cell Carcinoma of the Colorectum.2006
Author(s)
Seshimo I, Yamamoto H., Mishima H., Kurata A., Suzuki R., Ezumi K., Takemasa 1., Ikeda M., Fukushima T., Tujinaka T., Sekimoto M., Kikkawa N., Takenoshita S., Monden M.
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Journal Title
J.Exp.Clin.Cancer Res 25
Pages: 433-442
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Low-dose oxaliplatin enhances the antitumor efficacy of paclitaxel in human gastric cancer cell lines.2006
Author(s)
Gu J., Yamamoto H., Lu X., Ngan CY., Tsujino T., Konishi K., Takemasa I., Ikeda M., Nagata H., Hashimoto S., Matsuzaki T., Sekimoto M., Takagi A., Monden M.
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Journal Title
Digestion. 74(1)
Pages: 19-27
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression of PPARdelta in multistage carcinogenesis of the colorectum : implications of malignant cancer morphology.2006
Author(s)
Takayama 0., Yamamoto H., Damdinsuren B., Sugita Y., Ngan CY., Xu X., Tsujino T., Takemasa I., Ikeda M., Sekimoto M., Matsuura N., Monden M.
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Journal Title
Br J Cancer 95(7)
Pages: 889-895
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-D : -glucose Uptake by Positron Emission Tomography in Colorectal Cancer.2006
Author(s)
Gu J., Yamamoto H, Fukunaga H, Danno K, Takemasa I, Ikeda M, Tatsumi M, Sekimoto M, Hatazawa J, Nishimura T, Monden M.
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Journal Title
Dig Dis Sci. 11(3)
Pages: 2198-205
Description
「研究成果報告書概要(欧文)」より
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