2006 Fiscal Year Final Research Report Summary
Quantitative analysis of mRNA of Intraductal papillary mucinous neoplasms: To differentiate carcinoma from benign neoplasms
| Project/Area Number |
17591412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NAGAI Eishi Kyushu University Hospital, First department of sureerv, Research Associate, 大学病院, 助手 (30264021)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masao Kyushu University, Department of surgery and clinical oncology, Professor, 大学院医学研究院, 教授 (30163570)
MIZUMOTO Kazuhiro Kyushu University Hospital, First department of surgery, Assistant professor, 大学病院, 講師 (90253418)
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| Project Period (FY) |
2005 – 2006
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| Keywords | gene / pancreatic cancer / diagnosis |
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| Research Abstract |
Intraductal papillary mucinous neoplasms(IPMN) are common cystic tumors of the pancreas and are known to show transition from adenoma to carcinoma accompanied by several molecular abnormalities. The prognosis of patients with intraductal papillary mucinous carcinoma is poor. It is very important to make a early diagnosis of carcinoma to reduce the mortality of the patients. We used quantitative real-time reverse transcription-PCR with gene specific priming to measure MUC1, MUC4, MUC5AC, MUC6, SlOOP, S100A11, Sonic hedghog(SHH), hTERT in various types of pancreatic tumours.
The quantitative analyses of MUC1, MUC5AC, S 100P, S100A11 and SHH are useful for differentiation between neoplasms and non-neoplastic lesions. There is significant differences in the expression of hTERT between carcinoma and IPMN. The hTERT analysis of pancreatic juice may provide some advantages for the follow-up of a subset of patients with IPMN.
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