Genomic alterations of the gastrointestinal cancers

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17591413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: KYUSHU UNIVERCITY
• Principal Investigator: YOSHITAKE Shinichirou Kyushu University, Hospital, Department of Anestheology, Assistant Professor, 大学病院, 講師 (80315142)
• Co-Investigator(Kenkyū-buntansha): INOUE Hiroshi Kyushu University, Medical Insttitute of Bioregulation, Department of Molecular and Cellular Biology, Associate Professor, 生体防御医学研究所, 助教授 (90203249) ; INOUE Kenji Kyushu University, Hospital, Department of Molecular and Cellular Biology, Fellow, 大学病院, 医員 (20403917)
• Project Period (FY): 2005 – 2006
• Keywords: DNA microarray / Esophageal cancer / BAC / microdissection / loss / gain / genomic alteration

Research Abstract

Genomic alterlations of the gastrointestinal cancer were surveyed with BAC-based DNA Microarray. 23 cases of esophageal cancer cases were employed and DNAs of the tumor and surrounding normal mucosa were extracted with lazar micirodissection apparatus and purified. BAC microarray comprising of 4030 human genomic spots were applied for the analysis. Amplitude level of each spots were all found to remain within the log ±0.5 of the signal deviation. Among 4.030 genomic spots, 33 representative loci were shown to be correlated with the patient's long-range prognosis. Each spot has an average of 1 to 5 genes, which might be closely related to carcinogenesis.

Research Products

• [Journal Article] BAC Clones Related to Prognosis in Patients with Esophageal Squamous Carcinoma : An Array Comparative Genomic Hybridization Study (2007)
  • Author(s): Hirasaki, S.他
  • Journal Title: Oncologist 12 Pages: 406-417
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease (2007)
  • Author(s): Utsunomiya, T. 他
  • Journal Title: World J Gastroenterol 33 Pages: 383-390
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] BAC Clones Related to Prognosis in Patients with Esophageal Squamous Carcinoma : An Array Comparative Genomic Hybridization Study. (2007)
  • Author(s): Hirasaki S, Noguchi T, Mimori K, Onuki O, Morita M, Inoue H, Sugihara K, Mori M, Hirano T.
  • Journal Title: Oncologist 12 Pages: 406-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease. (2007)
  • Author(s): Utsunomiya T, Okamoto M, Wakiyama S, Hashimoto M, Fukuzawa K, Ezaki T, Aishima S, Yoshikawa Y, Hanai T, Inoue H, Barnard G F, Mori M.
  • Journal Title: World J Gastroenterol 13(3) Pages: 383-90
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of skp2 expression in primary breast cancer. (2006)
  • Author(s): Sonoda H. 他
  • Journal Title: Clin Cancer Res 12 Pages: 1215-1220
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fatty acid binding protein 6 is overexpressed in colorectal cancer. (2006)
  • Author(s): Ohmachi T. 他
  • Journal Title: Clin Cancer Res 12 Pages: 5090-5095
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression (2006)
  • Author(s): Mimori, K. 他
  • Journal Title: Cancer Res 66 Pages: 2683-2690
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Significance of skp2 expression in primary breast cancer. (2006)
  • Author(s): Sonoda H, Inoue H, Ogawa K, Utsunomiya.T, Masuda TA, Mori M.
  • Journal Title: Clin Cancer Res 12(4) Pages: 1215-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fatty acid binding protein 6 is overexpressed in colorectal cancer. (2006)
  • Author(s): Ohmachi T, Inoue H, Mimori K, Tanaka F, Sasaki A, Kanda T, Fujii H, Yanaga K, Mori M.
  • Journal Title: Clin Cancer Res 12(17) Pages: 5090-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. (2006)
  • Author(s): Mimori K, Ishii H, Nagahara H, Sudo T, Yamashita K, Inoue H, Barnard GF, Mori M.
  • Journal Title: Cancer Res 66(5) Pages: 2683-90
  • Description: 「研究成果報告書概要(欧文)」より