2007 Fiscal Year Final Research Report Summary
Research of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography
Project/Area Number |
17591430
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
TANIGUCHI Hiroki Kyoto Prefectural University of Medicine, Division of Digestive Surgery, Department of Surgery, Associate Professor (20217136)
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Project Period (FY) |
2005 – 2007
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Keywords | Tositron emission comnuted tomorranh / PET / henatic blood flow / oxveen metabolism / elucose metabolism / henatic tumor / tumor blood flow |
Research Abstract |
Malignant tumors repeat cell division and also proliferation actively even in bad environment. Consequently, it is thought that the glycolytic pathway largely contributes to getting energy for cell proliferation. In other words, anaerobic glucose metabolism is greatly facilitated not in normal tissue but in malignant tumor. Examination with positron emission computed tomography (PEI) using 18F-fluorodeoxygluoose (FDG) is to apply this phenomenon. Even though differential diagnosis which the tumor is benign or malignant and definition of invasive area are difficult, FDG-PET makes qualitative diagnosis possible by imaging study. On the other hand, FDG-PET enable quantitative evaluation of tumor glucose metabolism Detection rate by FDG-PET is extremely low in hepatocellular carcinoma (HCC), although it in malignant tumor is high even in metastatic liver tumor. It is thought that fundamental differences between (HCC) and the other cancer are due to their blood supply. HCC is rich in the bl
… More
ood vessels than the other cancer and it blood supply is abundant. In other words, it is thought that glucose metabolism is active in HCC. FDG-PET is indicator of anaerobic glucose metabolism and negative image of FDG-PET indicate to aerobic metabolism. Namely, it is expected that there is inverse correlation between blood flow in the cancer and anaerobic glucose metabolic rate (detection rate of FDG-PEI).The purpose of this research is to clarify the reason of low detection rate of HCC in FDG-PET. The relationship between the blood supply and anaerobic glucose metabolism of the tumor seem to be universal exceeding the kind of neoplasm. As results, anaerobic glucose metabolism related to blood flow and oxygen consumption in HCC, and also it related to oxygen consumption rate in other malignant tumors. It was thought that xygen deficiency is supplemented with elevation of effective oxygen consumption (oxygen consumption rate) in malignant tumors, but oxygen deficiency is supplemented with increase in blood flow in HCC. Less
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[Journal Article] 膵腺胞細胞癌の1例2008
Author(s)
中村 寛子, 藤信 明, 真崎 武, 伊藤 剛, 中村 憲治, 渡辺 太治, 柏本 錦吾, 川口 耕, 谷口 弘毅, 内藤 和世
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Journal Title
京都府立与謝の海病院誌 5
Pages: 52-55
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 丘疹-紅皮症を契機に胃癌、大腸癌、前立腺癌が発見された1例2008
Author(s)
上田 英史, 藤信 明, 筏 さやか, 平山 きふ, 野本 剛史, 川口 耕, 柏本 錦吾, 中村 憲治, 渡辺 太治, 伊藤 剛, 谷口 弘毅, 内藤 和世
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Journal Title
京都府立与謝の海病院誌 5
Pages: 63-67
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 乳腺腺様嚢胞癌の1例2008
Author(s)
青木 史子, 中村 憲治, 伊藤 剛, 真崎 武, 柏本 錦吾, 川口 耕, 渡辺 太治, 藤信 明, 谷口 弘毅, 内藤 和世
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Journal Title
京都府立与謝の海病院誌 5
Pages: 68-74
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 大腸腺扁平上皮癌の1例2008
Author(s)
岡田 悟, 伊藤 剛, 真崎 武, 柏本 錦吾, 藤信 明, 渡辺 太治, 中村 憲治, 川口 耕, 谷口 弘毅, 内藤 和世
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Journal Title
京都府立与謝の海病院誌 5
Pages: 75-80
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] A Saved Case of Nonocclusive Mesenteric Ischemia with Portal Venous Gas by Simultaneous Operation2008
Author(s)
Toshiyuki, Kosuga, Nobuaki, Fuji, Tsuyoshi, Itoh, Taiji, Watanabe, Kingo, Kashimoto, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Japanese Journal of Gastroenterological Surgery 41-1
Pages: 111-116
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Port site herniation of the small bowel following laparoscopy-assisted distal gastrectomy: a case report2008
Author(s)
Tsuyoshi, Itoh, Nobuaki, Fuji, Hiroki, Taniguchi, Taiji, Watanabe, Toshiyuki, Kosuga, Kingo, Kashimoto, Kazuyo, Naito
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Journal Title
Journal of Medical Case Reports 2
Pages: 48-51
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Investigation of case undergone appendectomy2008
Author(s)
Kingo, Kashimoto, Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 23-28
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Circumstances introduced maximal surgical blood order schedule (MSBOS) for elective operation2008
Author(s)
Hiroshi, Ohtaki, Nobuaki, Fuji, Takanori, Nagaoka, Yasuhito, Hayashi, Tsutomu, Yamaguchi, Takeshi, Nomoto, Masako, Ikuta, Kazuhiko, Tokita, Hiroki, Taniguchi
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 29-31
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case report of acinar cell carcinoma in the panceras2008
Author(s)
Hiroko, Nakamura, Nobuaki, Fuji, Takeshi, Mazaki, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 52-55
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case of focal nodular hyperplasia that was difficult to be differentiated from hepatocellular carcinoma2008
Author(s)
Tsutomu, Kawaguchi, Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 56-62
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case found gastric cancer, colorectal cancer, and prostatic cancer taking popular erythroderma opportunity2008
Author(s)
Hidefumi, Ueda, Nobuaki, Fuji, Sayaka, Ikada, Kifu, Hirayama, Takeshi, Nomoto, Tsutomu, Kawaguchi, Kingo, Kashimoto, Kenji, Nakamura, Taiji, Watanabe, Tsuyoshi, Itoh, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 63-67
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case of adenoid cystic carcinoma of the breast2008
Author(s)
Fumiko, Aoki, Kenji, Nakamura, Tsuyoshi, Itoh, Takeshi, Mazaki, Kingo, Kashimoto, Tsutomu, Kawaguchi, Taiji, Watanabe, Nobuaki, Fuji, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 68-74
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case of adenosquamous carcinoma of the colon2008
Author(s)
Satoru, Okada, Tsuyoshi, Itoh, Takeshi, Mazaki, Kingo, Kashimoto, Nobuaki, Fuji, Taiji, Watanabe, Kenji, Nakamura, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 75-80
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A resected case of cystic tumor of the pancreas2008
Author(s)
Katsutoshi, Shoda, Tsuyoshi, Itoh, Takeshi, Mazaki, Nobuaki, Fuji, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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Journal Title
Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
Pages: 81-85
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 地方病院の臨時手術の実際2007
Author(s)
藤信 明, 伊藤 剛, 中村 憲司, 渡辺 太治, 柏本 錦吾, 川口 耕, 谷口 弘毅, 内藤 和世
Organizer
第69回日本臨床外科学会総会
Place of Presentation
横浜
Year and Date
20071129-1201
Description
「研究成果報告書概要(和文)」より
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[Presentation] 閉鎖孔ヘルニア9例の検討2007
Author(s)
川口 耕, 藤信 明, 谷口 弘毅, 伊藤 剛, 中村 憲司, 渡辺 太治, 柏本 錦吾, 内藤 和世
Organizer
第69回日本臨床外科学会総会
Place of Presentation
横浜
Year and Date
20071129-1201
Description
「研究成果報告書概要(和文)」より
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[Presentation] Investigation of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography2007
Author(s)
Hiroki, Taniguchi, Tsutomu, Kawaguchi, Kingo, Kashimoto, Hiroko, Nakamura, Taiji, Watanabe, Kenji, Nakamura, Tsuyoshi, Itoh, Nobuaki, Fuji, Kazuyo, Naito
Organizer
The 69th annual congress of Japanese Surgical Association
Place of Presentation
1,Yokohama
Year and Date
20071129-12
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The actual situation of emergent operation in local hospital2007
Author(s)
Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 69th annual congress of Japanese Surgical Association
Place of Presentation
1,Yokohama
Year and Date
20071129-12
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Investigation of nine cases with obturator hernia hernia2007
Author(s)
Tsutomu, Kawaguchi, Nobuaki, Fuji, Hiroki, Taniguchi, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Kazuyo, Naito
Organizer
The 69th annual congress of Japanese Surgical Association
Place of Presentation
1,Yokohama
Year and Date
20071129-12
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 腹腔鏡下Nissen手術の経験2007
Author(s)
藤信 明, 伊藤 剛, 谷口 弘毅, 内藤 和世
Organizer
第20回日本内視鏡外科学会総会
Place of Presentation
仙台
Year and Date
20071119-21
Description
「研究成果報告書概要(和文)」より
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[Presentation] A Saved Case of Nonocclusive Mesenteric Ischemia with Portal Venous Gas by Simultaneous Operation2007
Author(s)
Toshiyuki, Kosuga, Nobuaki, Fuji, Hiroki, Taniguchi, Tsuyoshi, Itoh, Taiji, Watanabe, Kingo, Kashimoto, Kazuyo, Naito
Organizer
The 62th annual meeting of Japanese Society of Gastroenterological Surgery
Place of Presentation
Tokyo
Year and Date
20070718-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Examination of factors contributing to long term survival after surgery for liver metastasis from colorectal cancer2007
Author(s)
Tsuyoshi, Itoh, Nobuaki, Fuji, Hiroki, Taniguchi, Hisashi, Amaike, Taiji, Watanabe, Toshiyuki, Kosuga, Kingo, Kashimoto, Kazuyo, Naito
Organizer
The 62th annual meeting of Japanese Society of Gastroenterological Surgery
Place of Presentation
Tokyo
Year and Date
20070718-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case with endocrine cell carcinoma of the stomach found due to anemia2007
Author(s)
Kingo, Kashimoto, Nobuaki, Fuji, Tsuyoshi, Itoh, Taiji, Watanabe, Toshiyuki, Kosuga, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 62th annual meeting of Japanese Society of Gastroenterological Surgery
Place of Presentation
Tokyo
Year and Date
20070718-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Investigation for the effect of drugs affecting the blood flow in hepatic tumor2007
Author(s)
Hiroki, Taniguchi, Nobuaki, Fuji, Tsuyoshi, Itoh, Taiji, Watanabe, Toshiyuki, Kosuga, Kingo, Kashimoto, Kazuyo, Naito
Organizer
The 107th annual congress of Japan Surgical Society
Place of Presentation
Osaka
Year and Date
20070411-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 乳腺腺様嚢胞癌の1例2007
Author(s)
青木 史子, 伊藤 剛, 真崎 武, 藤信 明, 中村 憲司, 渡辺 太治, 柏本 錦吾, 谷口 弘毅, 内藤 和世
Organizer
第182回近畿外科学会
Place of Presentation
大阪
Year and Date
2007-12-08
Description
「研究成果報告書概要(和文)」より
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[Presentation] 膵腺房細胞癌の1例2007
Author(s)
中村 寛子, 藤信 明, 伊藤 剛, 中村 憲司, 渡辺 太治, 柏本 錦吾, 谷口 弘毅, 内藤 和世
Organizer
第182回近畿外科学会
Place of Presentation
大阪
Year and Date
2007-12-08
Description
「研究成果報告書概要(和文)」より
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[Presentation] 大腸腺扁平上皮癌の1例2007
Author(s)
岡田 悟, 伊藤 剛, 真崎 武, 藤信 明, 中村 憲司, 渡辺 太治, 柏本 錦吾, 谷口 弘毅, 内藤 和世
Organizer
第182回近畿外科学会
Place of Presentation
大阪
Year and Date
2007-12-08
Description
「研究成果報告書概要(和文)」より
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[Presentation] A case report of acinar cell carcinoma in the panceras2007
Author(s)
Hiroko, Nakamura, Nobuaki, Fuji, Takeshi, Mazaki, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case of focal nodular hyperplasia that was difficult to be differentiated from hepatocellular carcinoma2007
Author(s)
Tsutomu, Kawaguchi, Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case found gastric cancer, colorectal cancer, and prostatic cancer taking popular erythroderma opportunity2007
Author(s)
Hidefumi, Ueda, Nobuaki, Fuji, Sayaka, Ikada, Kifu, Hirayama, Takeshi, Nomoto, Tsutomu, Kawaguchi, Kingo, Kashimoto, Kenji, Nakamura, Taiji, Watanabe, Tsuyoshi, Itoh, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case of adenoid cystic carcinoma of the breast2007
Author(s)
Fumiko, Aoki, Kenji, Nakamura, Tsuyoshi, Itoh, Takeshi, Mazaki, Kingo, Kashimoto, Tsutomu, Kawaguchi, Taiji, Watanabe, Nobuaki, Fuji, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case of adenosquamous carcinoma of the colon2007
Author(s)
Satoru, Okada, Tsuyoshi, Itoh, Takeshi, Mazaki, Kingo, Kashimoto, Nobuaki, Fuji, Taiji, Watanabe, Kenji, Nakamura, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A resected case of cystic tumor of the pancreas2007
Author(s)
Katsutoshi, Shoda, Tsuyoshi, Itoh, Takeshi, Mazaki, Nobuaki, Fuji, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Investigation of 293 cases with acute appendicitis from 2001 to 20062007
Author(s)
Kingo, Kashimoto, Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
Osaka
Year and Date
2007-12-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Generalized peritonitis caused by disease other than of digestive organ2007
Author(s)
Kingo, Kashimoto, Nobuaki, Fuji, Tsuyoshi, Itoh, Taiji, Watanabe, Toshiyuki, Kosuga, Hiroki, Taniguchi, Kazuyo, Naito
Organizer
The 181st annual meeting of Kinki Surgical Society
Place of Presentation
Kyoto
Year and Date
2007-05-12
Description
「研究成果報告書概要(欧文)」より