2006 Fiscal Year Final Research Report Summary
Study on regeneration process and molecular mechanism of liver congestion
| Project/Area Number |
17591448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
YAMANAKA Junichi Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90289083)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Jiro Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (90199373)
IIMURO Yuji Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30252018)
HIRANO Tadamichi Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 講師 (90340968)
SUGIMOTO Takaaki Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (60399152)
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| Project Period (FY) |
2005 – 2006
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| Keywords | liver congestion / liver regeneration / liver transplantation |
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| Research Abstract |
Adult LDLT requires a right lobe graft for adequate liver volume demand. However, a right lobe graft potentially has problems of hepatic venous congestion, which is caused by absence of drainage via middle hepatic vein (MHV) tributaries (V5 and V8). Preoperative prediction of the congested liver volume has never been achieved. The importance of optimal venous outflow for sufficient liver function has become evident along with the development of right lobe LDLT. Venous congestion would result in functional impairment or even necrosis, predisposing to biliary and infectious complications. In LDLT using the right lobe, hepatic venous branch with an diameter of 5mm or more has been believed to require reconstruction. However, no quantifiable criteria for the venous reconstruction have been available to avoid liver congestion. The volumetric estimation of the hepatic venous drainage is required to avoid liver graft and donor residual liver congestion. We have reported the usefulness of our 3D simulation system for prediction hepatic venous drainage area (HEPATOLOGY 2005, J HEPATOBILIARY PANCREAT SURG 2006, ADVANCES IN MEDICAL SCIENCES 2006, WORLD J SURG in press). In this study, we observed introduction of FITC oligo to Kupffer cell using HVJ-liposome in rat model as preliminary experiment. In acute liver injury model, increase in serum inflammatory cytokines such as TNF-α, IL-1β, IL-12, IL-18 was also indicated. Currently, the regulatory effect of NFκB decoy on these inflammatory cytokines are under investigation with regard to liver regeneration in hepatic congestion model.
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