• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Final Research Report Summary

Intrinsic stem cell promote neuronal regeneration by oligomerization of A β 1-42monomer

Research Project

Project/Area Number 17591513
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKobe University

Principal Investigator

KONDOH Takeshi  Kobe University, School of Medicine, Associate Professor (50273769)

Co-Investigator(Kenkyū-buntansha) MATSUMOTOQ Akira  Foundation for Biomedical Research and Innovation, 脳疾患病態解析部, Director (80181759)
KOHMURA Eiji  Kobe University, Graduate School of Medicire, Professor (30225388)
Project Period (FY) 2005 – 2007
KeywordsBone marrow stromal cells / organotopic hipocampal slice / 海馬切片培養
Research Abstract

Bone marrow stromal cells taken from EGFP transgenic mice were sorted by magnetic beads with surface markers of Sca-1 and Thy-1. The cells were then co-cultured on organotopic hippocampal slice or with neuronal cell feeder in dish. On hippocampus, both Sca-1 and Thy-1 positive cells showed 4- 8 folds higher potential to show neuron-like morphology than negative cells. In dish, negative cells fewly survived but each positive cells survived and showed neuron-like differentiation. In both culture condition, retinoic acid supplement accelerate differentiation. Differentiated Sca-1 and Thy-1 positive cells were immunohistochemically GFAP- and NeuN-negative but nestin-, neurofilament and NSE-positive. Neuron-like differentiation of bone marrow cells can be enhanced by selection using cell surface proteins.

  • Research Products

    (2 results)

All 2007

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Effect of VEGF Receptor Antagonist (VGA1155) on Brain Edema in the Rat Cold Injury Model.2007

    • Author(s)
      Koyama J, Miyake S, Sasayama T, Kondoh T, Kohmura e
    • Journal Title

      Kobe J Med Sci. 53

      Pages: 199-207

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of VEGF Receptor Antagonist (VGA1155) on Brain Edema in the Rat Cold Injury2007

    • Author(s)
      Koyama, J, Miyake, S, Sasayama, T, Kondoh, T, Kohmura, E
    • Journal Title

      Kobe J Med Sci 53

      Pages: 199-207

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2010-02-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi