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2007 Fiscal Year Final Research Report Summary

Neuronal re-organization and functional recovery following activity dependent BDNF upregulation

Research Project

Project/Area Number 17591522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOita University

Principal Investigator

FUJIKI Minoru  Oita University, Department of Neurosurgery, School of Medicine, Professor (90231563)

Co-Investigator(Kenkyū-buntansha) HIKAWA Takamitsu  Oita University, Dept. of Neurosurgery, School of Medicine, Assistant Professor (20238257)
KUBO Takeshi  Oita University, Dept. of Neurosurgery, School of Medicine, Assistant Professor (80404375)
Project Period (FY) 2005 – 2007
KeywordsCerebral ischemia / Neuronal death / Preconditioning / Magnetic stimulation / Gene expression / BDNF / Neuroprotection / Neuronal reorganization
Research Abstract

Object. The present study demonstrates that repetitive transcranial magnetic stimulation (rTMS) induces ischemic tolerance against delayed neuronal death (DND) of hippocampal neurons following an otherwise lethal ischemic insult.
Methods. Various regimens of rTMS were delivered to adult gerbils at various times prior to an episode of ischemia induced by transient(5min.) bilateral common carotid artery occlusion(BCCO). The extent of delayed neuronal death in the CA1 region of the hippocampus was assessed quantitatively 7 days after the transient ischemic episode.
We will evaluate whether when rTMS will delivered 2-5 days prior to BCCO, delayed neuronal death will be substantially attenuated as reported in ischemic tolerance. We will evaluate the degree of neuroprotection by BDNF upregulation in the animals in the group that was stimulated 2 days prior to BCCO, whether neuron density in the CA1 sector was significantly higher in the rTMS pretreatment group than in the ischemia-only group. A similar degree of neuron sparing will be seen when stimulation was delivered 3, 4, or 5 days prior to BCCO. Effectiveness of rTMS was evaluated whether when stimulation was delivered at frequencies of 25 and 50 Hz. We will also evaluate whether stimulation at 25 Hz stimulation for 128 seconds(3200 pulses) is more effective than stimulation at 50 Hz for 64 seconds(3200 pulses) or 128 seconds(6400 pulses). Clinical application will be performed after hardware spec-up with ethical committee approve.

  • Research Products

    (12 results)

All 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Navigated Brain Stimulation for Preoperative Anatomic and Functional Identification of Impaired Motor Cortex in a Patient With Meningioma2007

    • Author(s)
      Fujiki M, Hikawa T, Abe T, Anan M, Sugita K, Kobayashi H
    • Journal Title

      Neurosurgery Quarterly 17

      Pages: 33-39

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Neuroprotective and antiamnesic effect of donepezil,a nicotinic acetyl choline-receptor activator,on concessive mild traumatic brain injury in rats2007

    • Author(s)
      Fujiki M, Kubo T, Kamida T, Sugita K, Hikawa T, Abe T, Ishii K, Kobayashi H.
    • Journal Title

      J Clin Neurosci. 14

      Pages: 1240-1245

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone limits secondary injury,neuronal death,and proegrssive necrosis and cavitation after spinal cord inijury2007

    • Author(s)
      Fujiki M
    • Journal Title

      J Neurotrauma 30

      Pages: 15-20

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Intraoperative corticomuscular motor evoked potentials for evaluation of motor function:a comparison with corticospinal D and I waves2007

    • Author(s)
      Fujiki M
    • Journal Title

      J Neurosurg. 104

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Navigated Brain Stimulation for Preoperative Anatomic and Functional Identification of Impaired Motor Cortex in a Patient With Meningioma2007

    • Author(s)
      Fujiki, M., Hikawa, T., Abe, T., Anan, M., Sugita, K., Kobayashi, H.
    • Journal Title

      Neurosurgery Quarterly 17

      Pages: 33-39

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on concussive mild traumatic brain injury in rats2007

    • Author(s)
      Fujiki, M., Kubo, T., Kamida, T., Sugita, K., Hikawa, T., Abe, T., Ishii, K., Kobayashi, H.
    • Journal Title

      J Clin Neurosci 14

      Pages: 1240-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury2007

    • Author(s)
      Fujiki, M.
    • Journal Title

      J Neurotrauma 30

      Pages: 15-20

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intraoperative corticomuscular motor evoked potentials for evaluation of motor function : a comparison with corticospinal D and I waves2007

    • Author(s)
      Fujiki, M., Furukawa, Y., Kamida, T., Anan, M., Inoue, R., Abe, T., Kobayashi, H.
    • Journal Title

      J Neurosurg 104

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] International TMS Multisite Study;Planning and design2007

    • Author(s)
      Fujiki M.
    • Organizer
      International Society for TMS
    • Place of Presentation
      Glasgow,UK
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] International TMS Multisite Study ; Planning and design2007

    • Author(s)
      Fujiki, M.
    • Organizer
      International Society for TMS
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(欧文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.med.oita-u.ac.jp/neurosurgery/index.html

  • [Patent(Industrial Property Rights)] 脳神経外科術中運動野同定・機能的ナビゲーションシステム2007

    • Inventor(s)
      藤木 稔
    • Industrial Property Rights Holder
      藤木 稔
    • Industrial Property Number
      特願2007-303696号
    • Filing Date
      2007-10-25
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2010-02-04  

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