2007 Fiscal Year Final Research Report Summary
Intraoperative neurophysiology for motor-related cortecies and functional recovery after injury
| Project/Area Number |
17591535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
FUKAYA Chikashi Nihon University, School of Medicine, Associate Professor (50287637)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Hideki Nihon University, School of Medicine, Professor (20328735)
YAMAMOTO Takamitsu Nihon University, School of Medicine, Professor (50158284)
KATAYAMA Yoichi Nihon University, School of Medicine, Professor (00125048)
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| Project Period (FY) |
2005 – 2007
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| Keywords | motor evoked potential / D-wave / primary motor cortex / basal ganglia / motor thalamus / intraonerative neuronhysiology / deep brain stimulation / mapping |
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| Research Abstract |
On tumor resection close to the motor pathway, several types of functional mapping such as preoperative neuroimaging and intraoperative electrophysiological techniques have been extensively used in the past few decades to decrease postoperative morbidity. In particular, evoked-potential recording following a direct electrical stimulation of the cortex has been used as an intraoperative mapping and monitoring method during surgery.
The corticospinal D-wave has been confirmed as an indicator for the mapping of M1(primary motor cortex) and for monitoring CST (corticospinal tract) function during surgery. We already reported the functional outcomes due to SMA (supplementary motor cortex) and PM (premotor cortex) impairment are considerably different from that of the M1 impairment. Motor deficit caused by damage to SMA and/or PM is often expected to be compensated, and patients often fully recover in a few months. Therefore, to differentiate the M1 from other motor-related corticies is important. As previously reported, responses from muscles can be evoked by stimulating not only M1 and CST but also SMA, PM, and probably their descending fibers. This feature is unfavorable for achieving maximum tumor resection with minimum postoperative deficits because The corticospinal D-wave can be recorded only when M1 is stimulated.
On the other hand, attention has mainly been paid functional mapping of the cortex. However, intramedullary tumors such as glial tumors commonly invade subcortical structures as well as the cortices ; thus, definitive deficits may occur because of surgical impairments to eloquent pathways running through subcortical structures. Subcortical mapping using the D-wave elicited by monopolar stimulation can provide useful information that can be used to prevent postoperative motor deficit. In particular, the potential of this method for determining the distance of the stimulation point from the CST using D-wave amplitude is promising.
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[Journal Article] Recording of corticospinal evoked potential for optimum placement of motor cortex stimulation electrodes in the treatment of post-stroke pain2007
Author(s)
Yamamoto, T., Katayama, Y., Obuchi, T., Kano, T., Kobayashi, K., Oshima, H., Fukaya, C., Kakigi, R
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Journal Title
Neurol Med Chir (Tokyo) 47
Pages: 409-414
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Thalamic deep brain stimulation for writer's cramp2007
Author(s)
Fukaya, C., Katayama, Y., Kano, T., Nagaoka, T., Kobayashi, K., Oshima, H., Takamitsu, Yamamoto, T
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Journal Title
J Neurosurg 107
Pages: 977-982
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Subcortical-mapping for corticospinal tract using D-wave2007
Author(s)
Chikashi, Fukaya, Katsunori, Shijo, Takafumi, Nagaoka, Kazutaka, Kobayashi, Hideki, Oshima, Takamitsu, Yamamoto, Yoichi, Katayama
Organizer
First Congress of the International Society of Intraoperative Neurophysiology
Place of Presentation
Lucerne
Year and Date
20071100
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Recording of corticospinal MEP for placement of motor cortex stimulation electrodes in the treatment of post-stroke pain2007
Author(s)
Takamitsu, Yamamoto, Toshiki, Obuchi, Toshikazu, Kano, Kazutaka, Kobayashi, Hided, Oshima, Chikashi, Fukaya, Yoichi, Katayama
Organizer
The 6th Congress of Asian Society for Stereotactic, Functional and Computer Assisted Neurosurgery
Place of Presentation
Mt. Fuji, Japan
Year and Date
20070500
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Intraoperative Neurophysiological monitoring and mapping2005
Author(s)
Fukaya, C., Nagaoka, T., Kobayashi, K., Oshima, H., Yamamoto, T., Katayama, Y
Organizer
6th International Congress on Minimally Invasive Neurosurgery
Place of Presentation
Nagoya, Japan
Year and Date
20050300
Description
「研究成果報告書概要(欧文)」より
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