2007 Fiscal Year Final Research Report Summary
Elucidation of the molecular mechanism of Ossification of the Posterior Longitudinal Ligament
| Project/Area Number |
17591554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AE Keisuke Tokyo Medical and Dental University, 大学院・医歯学総合研究科, Assistant Professor (20376726)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOMIYA Kenichi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, Professor (20111594)
TAKEDA Shu Tokyo Medical and Dental University, 大学院・医歯学総合研究科, Associate Professor (30376727)
KAWABATA Shigenori Tokyo Medical and Dental University, 大学院・医歯学総合研究科, Assistant Professor (50396975)
TOMORI Masaki Tokyo Medical and Dental University, 医学部・附属病院, Fellow (30431919)
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| Project Period (FY) |
2005 – 2007
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| Keywords | ossification of the ligament / Runx / transgenic mouse |
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| Research Abstract |
We addressed the role of transcription factor Runxl and Runx2 in the development of Ossification of the Posterior Longitudinal Ligament (OPLL) by using Runx deficient mice.
We crossed ttw mice, a naturally developed mouse model for OPLL, with Runx deficient mice. We then analyzed histologically ttw mice/Runx2 heterozygote mice in comparison with ttw mice. By micro Computed tomography analysis, the ossification of ttw/Runx2 heterozygote mice was reduced almost to the 50% in the calcification volume to that of ttw mice. Histologically, chondrocyte hypertrophy, accumulation of type X collagen was significantly decreased. These results suggest that Runx2 play pivotal role in the development of OPLL.
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Research Products
(22 results)
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[Presentation] 仙骨巨細胞腫の治療2007
Author(s)
阿江啓介
Organizer
第39回日本整形外科学会骨軟部腫瘍学術集会パネル
Place of Presentation
北海道札幌市
Year and Date
2007-07-06
Description
「研究成果報告書概要(和文)」より
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