2007 Fiscal Year Final Research Report Summary
Cellular mechanisms of contractile and vasodilating actions of anesthetics in vascular smooth muscle
| Project/Area Number |
17591644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki (2007)
Kagoshima University (2005-2006) |
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Principal Investigator |
TSUNEYOSHI Isao University of Miyazaki, Faculty of Medicine, Department of Anesthesiology & Intensive Care, Professor (90301390)
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| Project Period (FY) |
2005 – 2007
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| Keywords | smooth muscle vascular / shock / vascular reaction / sepsis / anesthetic / human artery / cardio-pulmonarv-bypass |
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| Research Abstract |
First year; Objective: To determine the direct contractile effects of angiotensin II (AII) and vasopressin (VP), and the effects of combinations of these agonists, in human isolated gastroepiploic arteries in vitro. Conclusion: There is a powerful synergism between the contractile effects of low-dose VP and AII in this human isolated artery. Moreover, the elevations of plasma AII and VP levels during hemorrhage suggest that this synergism may be both physiologic Ally and clinic Ally important in optimizing vasoconstriction and maintaining blood pressure in such critical states.
Second year ; Objective : There are few data available on the effect of ultrasonic skeletonization with the harmonic scalpel on internal thoracic artery (ITA) and gastroepiploic artery (GEA) vessel function. Conclusion : Ultrasonic complete skeletonization with the harmonic scalpel may retain smooth muscle function of skeletonized grafts, whereas endothelial function of ultrasonic skeletonized grafts may be significantly compromised.
Third year ; Objective ; In the direct contractile effects of angiotensin II (AII), this peptide induced strong tachyphylaxis, and thus the contractile performance were degraded in a short time. Therefore, the aim of this study is to determine the mechanisms responsible for the AII-induced tachyphylaxis in human vascular smooth muscle, such as a gastroepiploic arteries.
Conclusion; There is a possibility that vasodilator prostaglandins, which are released by AII, are involved in AII tachyphylaxis in humans, since pretreatment with indomethacin reduces, but does not abolish, the tachyphylaxis
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[Journal Article] Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisiting mitral regurgitation : improvement2005
Author(s)
T., Omae, Y., Kakihana, A., Matsunaga, I., Tsuneoshi, K., Kawasaki, Y., Kanmura, R., Sakata
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Journal Title
Anesthesia & Analgesia 101 : 1
Pages: 2-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Differential pharmacologic sensitivities of phosphodiesterase3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries2005
Author(s)
M., Onomoto, I., Tsuneyoshi, A., Yonetani, S., Suehiro, K., Matsumoto, E., Sakata, Y., Kanmura
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Journal Title
Anesthesia & Analgesia 101 : 4
Pages: 950-956
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 「研究成果報告書概要(欧文)」より2005
Author(s)
T., Hidaka, I., Tsuneyoshi, WA., Boyle, M., Onomoto, A., Yonetani, J., Hamasaki, R., Katai, Y., Kanmura
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Journal Title
Critical Care Medicine 33 : 11
Pages: 2613-2620
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[Book] 最新整形外科学大系2007
Author(s)
恒吉 勇男、上村 裕一
Total Pages
42-51
Publisher
中山書店
Description
「研究成果報告書概要(和文)」より
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