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2007 Fiscal Year Final Research Report Summary

N-cadherin expression is associated with bladder cancer progression and poor prognosis

Research Project

Project/Area Number 17591664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

TOMITA Kyoichi  The University of Tokyo, Hospital, associate professor (20272578)

Co-Investigator(Kenkyū-buntansha) KUME Haruki  The University of Tokyo, Hospital, assistant professor (10272577)
KITAMURA Tadaichi  The University of Tokyo, Hospital, Professor (70010551)
Project Period (FY) 2005 – 2007
Keywordsbladder cancer / invasion / E-cadherin / N-cadherin / prognosis / confocal scanning laser microscopy / cadherin switching
Research Abstract

We investigated the expression of N-cadherin in cultured human bladder cancer cells and human bladder cancer specimens. We aim at establishing the pathological role of induced expression of N-cadherin in bladder cancer progression and show a correlation between expression of cadherins and clinical outcome. In 45 bladder cancer specimens of radical cystectomy or transurethral resection, double-label immunofluorescece staining of both E-and N-cadherin was performed, and patterns of these expressions were evaluated. We investigated to clarify the localization of N-cadherin expression using confocal scanning laser microscopy (CSLM). In cultured cancer cells, we did not confirm to change from E-cadherin to n-cadherin according to hepatocyte growth factor. Normal expression of E-cadherin was found in 20 cases (44.4%), and positive expression of N-cadherin (membranous pattern and/or dotted pattern) was found in 24 cases (53.3%). Aberrant expression of E-cadherin and positive expression of N-cadherin have a significant correlation with tumor stage. The ratio of 5 years survival rate was as follows:E-cadherin (normal 100%: aberrant 59.2%), and N-cadherin (positive 62.5%: negative 94.7%), respectively. There was a significant difference in survival between normal and aberrant expression of E-cadherin, or between positive and negative expression of N-cadherin. Bladder cancer cells invading stroma strongly showed positive N-cadherin expression by CSLM. In bladder cancer patients, there is a significant correlation between E-cadherin and N-cadherin, and pT stage. There is a significant correlation between aberrant expression of E-cadherin and positive expression of N-cadherin. Aberrant expression of E-cadherin and positive expression of N-cadherin show poor prognostic factors in survival of bladder cancer patients. Our data revealed N-cadherin expression may play an important role in bladder cancer invasion and metastasis.

  • Research Products

    (2 results)

All 2006

All Presentation (2 results)

  • [Presentation] N-cadherin expression is associated with blabber cancer progression and poor prognosis2006

    • Author(s)
      Kyoichi Tomita
    • Organizer
      21th congress of European association of Urology
    • Place of Presentation
      Istanbul
    • Year and Date
      2006-03-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] N-cadherin expression is associated with blabber cancer progression and poor prognosis.2006

    • Author(s)
      Tomita K, Kume H, Kashibuchi K, Kitamura T.
    • Organizer
      21th congress of European association of Urology
    • Place of Presentation
      Istanbul
    • Year and Date
      2006-03-18
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-06-09  

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