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2006 Fiscal Year Final Research Report Summary

A fundamental study about the new therapeutic stratedy with cell mediated immunity sysytem for uterine cervical cancer and CIN

Research Project

Project/Area Number 17591716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tsukuba

Principal Investigator

OKI Akinori  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (60334067)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroyuki  筑波大学, Graduate School of Comprehensive Human Sciences, Professor (40158415)
Project Period (FY) 2005 – 2006
KeywordsHPV / HLA / cervical cancer / immunotherapy
Research Abstract

As a result of multi-institutions collaborative investigation intended to elucidate the natural history by observating CIN1/2, it developed that there were two steps by the process during carcinogenesis of CIN1/2. The study subjects consisted of 570 women aged 54 or younger with cytologically and histologically confirmed CIN 1/2. CIN cases included 479 CIN 1 and 91 CIN 2. The median follow-up time was 38.1 months. The 570 subjects were divided into 361 (63.3%) patients with regression, 172 (28.6%) patients with persistence and 46 (8.1%) patients with progression. The median regression time was 6.5 months and the median progression time was 17.9 months, suggesting that regression is an early event and progression is a late event in the national history of CIN 1/2. Thus, the first step is a step to persist without regression of the CIN1/2 within two years usually disappearing. The second step is the step that persisted CIN1/2 which continued progresses to CIN3. We used hazard ratio after … More adjustment of Age, CIN grade and HPV category to evaluate various prognostic factors, because the three factors were closely associated with both regression and progression in the univariate analysis. Age, CIN grade, HPV risk category, smoking, marital status, and number of sexual partners were significantly associated with CIN persistence, whereas CIN grade, HPV risk category and HLA class II allele (HLA DRB1*1302) had significant association with CIN progression.
In such a background we paid attention to the type of HPV and the haplotype of the HLA Class I antigen in elements of the uterine cervix cancer.
It is obvious that high-risk HPV infection is a direct trigger in the carcinogenesis of uterine cervix cancer, but evasion from virus immunity and tumor immunity by the host is indispensable in carcinogenesis process. These immune mechanism due to cell-mediated immunity through the T lymphocyte, and co-existence of HLA class I molecules and the HPV specific peptide is important for this system. The complex of HLA class I molecules with peptide consisting of around 9-10 amino acids, is recognized as an antigen by a T lymphocytes. The binding affinity of the peptide is HLA type specific, so that the immune response depends on the difference of the HLA haplotypes.
13 kinds of cell lines, which were derived from cervical cancer, were analysed both HPV and HLA typings. HPV16 was detected by seven lines of those, and HPV18 was detected by three, and it was not detected from one. Three of seven HPV16 positive lines were positive for A*1101 and five of these positive for A*2401, but did not accumulate the HLA of seven HPV16 positive lines in a specific haplotype in B, C locus. The distribution in which locus did not have regional control and significant difference. About half in HLA A, B locus and about two-thirds in C locus were coverd by these seven HPV16 positive cell lines, A susceptibility of the cervical cancer by the difference of the HLA might be identified in future by comparing the HLA distribution of the uterine cervix cancer patient of the specific HPV (especially HPV16) positive with normal regional control. Less

  • Research Products

    (8 results)

All 2006

All Journal Article (8 results)

  • [Journal Article] ホート研究に基づくCIN1/2の管理方針と高危険群の抽出2006

    • Author(s)
      沖明典
    • Journal Title

      日本産科婦人科学会雑誌 58・11

      Pages: 1739-44

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] HPV感染と危険因子2006

    • Author(s)
      沖明典、吉川裕之
    • Journal Title

      産婦人科治療 93・6

      Pages: 633-41

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      S.Miura, K.Matsumoto, A.Oki, T.Satoh, H.Tsunoda, T.Yasugi, H.Yoshikawa
    • Journal Title

      International Journal of Cancer 119・11

      Pages: 2713-15

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia.2006

    • Author(s)
      K.Matsumoto, T.Yasugi, A.Oki, T.Fujii, C.Nagata, S.Sekiya, H.Hoshiai, Y.Taketani, T.Kanda, T.Kawana, H.Yoshikawa
    • Journal Title

      Cancer Letters 231・2

      Pages: 309-13

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of high-risk CIN 1/2 and its management based on a large scale cohort study of CIN 1/2 in Japan2006

    • Author(s)
      A.Oki
    • Journal Title

      Nippin Sanka-Hujinnka-gakkai zasshi Vol.58(11)

      Pages: 1739-1744

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] HPV infection and itsrisk factors2006

    • Author(s)
      A.Oki, H.Yoshikawa
    • Journal Title

      Safujina chiryou Vol.93(6)

      Pages: 633-41

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      S.Miura, K.Matsumoto, A.Oki, T.Satoh, H.Tsunoda, T.Yasugi, H.Yoshikawa
    • Journal Title

      International Journal of Cancer Vol.119(11)

      Pages: 2713-2715

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia2006

    • Author(s)
      K.Matsumoto, T.Yasugi, A.Oki, T.Fujii, C.Negate, S.Sekiya, H.Hoshiai, Y.Taketani, T.Kanda, T.Kawana, H.Yoshikawa
    • Journal Title

      Cancer Letters Vol.231(2)

      Pages: 309-313

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2011-06-18  

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