2007 Fiscal Year Final Research Report Summary
Immunological Control of Human Papillomavirus Infections
| Project/Area Number |
17591722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUMOTO Koji University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (30302714)
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| Project Period (FY) |
2005 – 2007
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| Keywords | human papillomavirus / HPV / antibody response / IL-10 / cervical cancer / CIN |
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| Research Abstract |
1) IgG antibodies to HPV16, 52, 58 and 6 LI-Capsids and Spontaneous Regression of Cervical Intraepithelial Neoplasia
A total of 116 Japanese women with cervical intraepithelial neoplasia grade I/II (CIN I/II) were tested for cervical human papillomavirus (HPV) DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.
2) Interleukin-10 Promoter Polymorphism and Susceptibility to Cervical Cancer among Japanese women
A substitution of G for A at position -1082 in interleukin-10 (IL-10) promoter region is known to produce significantly higher levels of IL-10. Therefore, IL-10 promoter polymorphism may affect immunological control of oncogenic human papillomavirus (HPV) infections. To address a possible association between IL-10 promoter polymorphism and risk of cervical cancer, a total of 429 Japanese women [160 normal cytology, 186 CIN (cervical intraepithelial neoplasia) and 83 ICC (invasive cervical cancer)] were analyzed for IL-10 promoter polymorphisms. Using cellular DNA from cervical samples, we performed an ARMS-PCR method for detection of A and/or G at-1082 in IL-10 promoter region. The frequency of genotypes (G/G or G/A) associated with higher IL-10 production was 9.3% for normal cytology: 18.8% for CIN: 32.5% for ICC (P for trend <0.001). The highest IL-10 expression genotype G/G was detected in 1% of normal cytology, 1% of CIN and 6% of ICC. Our data suggest that IL-10 promoter polymorphism may contribute to the development of cervical cancer and its precursor lesions.
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Research Products
(36 results)
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[Journal Article] Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer2007
Author(s)
K. Uno, S. Homma, T. Satoh, K. Nakanishi, D. Abe, K. Matsumoto, A. Oki, H. Tsunoda, I. Yamaguchi, T. Nagasawa, H. Yoshikawa, K. Aonuma
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Journal Title
British Journal of Cancer Vol.96(peer reviewed)
Pages: 290-295
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] High incidence of silent venous thromboembolism before treatment in ovarian cancer2007
Author(s)
T. Satoh, A. Oki, K Uno, M. Sakurai, H. Ochi, S. Okada, R. Minami, K. Matsumoto, YO Tanaka, H. Tsunoda, S. Homma, H. Yoshikawa
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Journal Title
British Journal of Cancer Vol.97(peer reviewed)
Pages: 1053-1057
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IgG antibodies to human papillomavirus 16, 52, 58, and 6 L1 capsids : case-control study of cervical intraepithelial neoplasia in Japan2007
Author(s)
K. Matsumoto, T. Yasugi, S. Nakagawa, K. Kawana, N. Yaegashi, T. Iwasaka, K. Kanazawa, Y. Taketani, H. Yoshikawa
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Journal Title
Journal of the Japanese Society of Gynecologic Oncology Vol.25(peer reviewed)
Pages: 98-105
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia2006
Author(s)
K. Matsumoto, T. Yasugi, A. Oki, T. Fujii, C. Nagata, S. Sekiya, H. Hoshiai, Y. Taketani, T. Kanda, T. Kawana, H. Yoshikawa
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Journal Title
Cancer Letters Vol.231(peer reviewed)
Pages: 309-313
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of a cellular ubiquitin-protein liga E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillpmavirus E62006
Author(s)
Y. Matsumoto, S. Nakagawa, T. Yano, S. Takizawa, K. Nagasaka, K. Nakagawa, T. Minaguchi, O. Wada, H. Ooishi, K. Matsumoto, T. Yasugi, T. Kanda, J. M. Huibregtse, Y. Taketani Y.
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Journal Title
Journal of Medical Virology Vol.78(peer reviewed)
Pages: 501-507
Description
「研究成果報告書概要(欧文)」より
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