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2006 Fiscal Year Final Research Report Summary

Study of placental formation and functional differentiation by tissue specific stem cell transplantation

Research Project

Project/Area Number 17591728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

SUZUKI Ayako  Kyoto University, Graduate School of Medicine, assistant professor, 医学研究科, 助手 (90378696)

Co-Investigator(Kenkyū-buntansha) ITOH Hiroaki  Kyoto University, Graduate School of Medicine, lecturer, 医学研究科, 講師 (70263085)
YURA Shigeo  Kyoto University, Graduate School of Medicine, assistant professor, 医学研究科, 助手 (60335289)
SAGAWA Norimasa  Mie University, Graduate School of Medicine, professor, 医学系研究科, 教授 (00162321)
SUZUKI Yoshihisa  Kyoto University, Graduate School of Medicine, associate professor, 医学研究科, 助教授 (30243025)
ITOH Hiroshi  Kyoto University, Graduate School of Medicine, associate professor, 医学研究科, 助教授 (40252457)
Project Period (FY) 2005 – 2006
KeywordsIUGR / placenta / mononuclear cell / glucocorticoid / fetal growth
Research Abstract

The placenta plays an essential role in the growth of fetus in the uterus. Any insult in placental development, such as abnormal immune reaction or maternal malnutrition, can result in poor placental growth and placental insufficiency. In the present study, we evaluated an involvement of maternal bone-marrow derived mononuclear cells in the development of the placenta by transplanting these cells in growing placenta. Bone-marrow cells obtained from GFP transgenic mice were injected in the growing placenta and was observed to be retained in the placental tissue just prior to delivery. Moreover, GFP positive maternal mononuclear cells were observed in the placenta of non-GFP pups growing in the uterus of GFP transgenic dams, thus indicating that maternal mononuclear cells may contribute somehow to the formation of the placenta. In the present study, we also elucidated an involvement of glucocorticoid inactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 2(11βHSD2). 11βHSD2 was expressed in chorionic epithelium of the mouse placenta. 11βHSD2 expression in the placenta was increased by maternal food restriction during pregnancy. Therefore, it is implicated that fetus is protected from exposure to glucocorticoid in maternal circulation increased by food restriction stress. In addition, placental 11βHSD2 expression was further increased by feeding high protein diet during food restriction, together with improved fetal growth. These findings may give us a clue to develop a new strategy to have a good fetal outcome.

  • Research Products

    (8 results)

All 2005

All Journal Article (8 results)

  • [Journal Article] Experimental Transplantation Study for Possible Transformation of Bone Marrow Cells in the Mouse Placenta2005

    • Author(s)
      Kazuyo Kakui
    • Journal Title

      Placenta 26・8-9

      Pages: 678-685

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A case of spontaneous regression of congenital cystic adenomatoid malformation of the lung -Longitudinal examinations by magnetic resonance imaging2005

    • Author(s)
      Makoto Kawamura
    • Journal Title

      Congenital Anomalies 45・4

      Pages: 157-160

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 当科および関係病院で経験した婦人科疾患に合併した重症肺血栓塞栓症10例の解析2005

    • Author(s)
      鈴木彩子
    • Journal Title

      産婦人科の進歩 57・2

      Pages: 191-195

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 症例から学ぶ婦人科腫瘍学 子宮体部病変 非定型子宮筋腫(グレーゾーン)2005

    • Author(s)
      鈴木彩子
    • Journal Title

      日本産科婦人科学会雑誌 57・9

      Pages: N207-N210

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Experimental Transplantation Study for Possible Transformation of Bone Marrow Cells in the Mouse Placenta2005

    • Author(s)
      Kazuyo Kakui
    • Journal Title

      Placenta Vol.26

      Pages: 678-685

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case of spontaneous regression of congenital cystic adenomatoid malformation of the lung-Longitudinal examinations by magnetic resonance imaging2005

    • Author(s)
      Makoto Kawamura
    • Journal Title

      Congenital Anomalies Vol.45

      Pages: 157-160

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Retrospective study of patients with gynecological disease developing serious pulmonary embolism : a report of 10 cases2005

    • Author(s)
      Ayako Suzuki
    • Journal Title

      Adv Obstet Gynecol Vol.57

      Pages: 191-195

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Diagnostic criteria based on magnetic resonance imaging for uterine sarcoma2005

    • Author(s)
      Ayako Suzuki
    • Journal Title

      Acta Obst Gynaec Jpn Vol.57

      Pages: N207-N210

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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