2006 Fiscal Year Final Research Report Summary
Carrier cell-mediated ovarian cancer-specific cellular and immunological gene therapy by induction of CTL
| Project/Area Number |
17591745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University |
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Principal Investigator |
HAMADA Katsuyuki Ehime University, University Hospital, Lecturer, 医学部附属病院, 講師 (90172973)
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| Project Period (FY) |
2005 – 2006
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| Keywords | ovarian cancer / oncolytic adenovirus / IAI>3B / carrier cell / atellocolagen / pre-immunization / E1A / promoter |
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| Research Abstract |
Replication-competent viruses have been developed to treat cancers. However, their cytotoxic effects are insufficient, because infection with them is inhibited by generation of neutralizing antibodies. To address this limitation, we developed carrier cell system to deliver a replication-competent adenovirus. A549 carrier cell infected with oncolytic adenovirus AdE3-IAI.3B killed target cancer cells and this infection was uninhibited by antiadenovirus antibody and enabled repetitive infection. After the induction of antiadenoviral CTL responses by immunization of adenovirus, administration of carrier cells infected with a replication-competent adenovirus induced complete tumor regression. Adenovirus-GM-CSF augmented the antitumor effect of carrier cells by increasing antiadenoviral and antitumoral CTL responses. This novel carrier cell-mediated viral transfection system might prove useful in a variety of types of cancer therapy.
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Research Products
(14 results)
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[Journal Article] Immune response to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide.2006
Author(s)
Hamada, K., Sakaue, M., Sarkar, A., Buchl, S., Satterfield, W., Keeling M., Sastry, J., Roth, J.A, Follen, M.
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Journal Title
Gynecologic Oncology 99
Pages: S177-S186
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immune response to repetitive adenovirus- mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide2005
Author(s)
Hamada, K., Sakaue, M., Sarkar, A., Buchl, S., Satterfield, W., Keeling M., Sastry, J., Roth, J.A., Follen M.
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Journal Title
Gynecologic Oncology 99
Pages: S177-S186
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A repliation-selective adenoviral vector for head and neck cancers.2005
Author(s)
Tanaka, H., Shirakawa, T., Zhang, Z., Hamada, K., Gotoh, A., Nibu, K.
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Journal Title
Arch Otolaryngol Head Neck Surg 131
Pages: 630-634
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A replication-selective adenoviral vector for head and neck cancers.2005
Author(s)
Tanaka, H., Shirakawa, T.Zhang, Z., Hamada, K., Gotoh, A., Nibu, K.
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Journal Title
Arch Otolaryngol Head Neck Surg 131
Pages: 630-634
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Carrier cell-mediated infection of a replication-competent adenovirus for cancer gene therapy
Author(s)
Hamada, K., Desaki, J., Nakagawa, K., Shirakawa, T., Gotoh, A., Tagawa, M.
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Journal Title
Molecular Therapy (In print)
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Carrier cell-mediated infection of a replication-competent adenovirus for cancer gene therapy
Author(s)
Hamada, K., Desaki, J., Nakagawa, K., Shirakawa, T., Gotoh, A., Tagawa, M.
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Journal Title
Molecular Therapy (in print)
Description
「研究成果報告書概要(欧文)」より
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