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2006 Fiscal Year Final Research Report Summary

Carrier cell-mediated ovarian cancer-specific cellular and immunological gene therapy by induction of CTL

Research Project

Project/Area Number 17591745
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionEhime University

Principal Investigator

HAMADA Katsuyuki  Ehime University, University Hospital, Lecturer, 医学部附属病院, 講師 (90172973)

Project Period (FY) 2005 – 2006
Keywordsovarian cancer / oncolytic adenovirus / IAI>3B / carrier cell / atellocolagen / pre-immunization / E1A / promoter
Research Abstract

Replication-competent viruses have been developed to treat cancers. However, their cytotoxic effects are insufficient, because infection with them is inhibited by generation of neutralizing antibodies. To address this limitation, we developed carrier cell system to deliver a replication-competent adenovirus. A549 carrier cell infected with oncolytic adenovirus AdE3-IAI.3B killed target cancer cells and this infection was uninhibited by antiadenovirus antibody and enabled repetitive infection. After the induction of antiadenoviral CTL responses by immunization of adenovirus, administration of carrier cells infected with a replication-competent adenovirus induced complete tumor regression. Adenovirus-GM-CSF augmented the antitumor effect of carrier cells by increasing antiadenoviral and antitumoral CTL responses. This novel carrier cell-mediated viral transfection system might prove useful in a variety of types of cancer therapy.

  • Research Products

    (14 results)

All 2007 2006 2005 Other

All Journal Article (13 results) Book (1 results)

  • [Journal Article] Gene therapy. Review for ovarian cancer.2007

    • Author(s)
      Hamada, K.
    • Journal Title

      Nangai Shoten.

      Pages: 8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A denovirus-mediated transfer of human papillomavirus 18 E6/E7 antisense RNA and induction of apoptosis in cervical cancer.2006

    • Author(s)
      Hamada, K., Shirakawa, T., Gotoh, A., Roth, J.A., Follen, M
    • Journal Title

      Gynecologic Oncology 103

      Pages: 820-830

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Adenovirus-mediated transfer of human papillomavirus 18 E6/E7 antisense RNA and induction of apoptosis in cervical cancer.2006

    • Author(s)
      Hamada, K., Shirakawa, T, Gotoh, A., Roth, JA, Follen, M
    • Journal Title

      Gynecologic Oncology 103

      Pages: 820-830

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immune response to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide.2006

    • Author(s)
      Hamada, K., Sakaue, M., Sarkar, A., Buchl, S., Satterfield, W., Keeling M., Sastry, J., Roth, J.A, Follen, M.
    • Journal Title

      Gynecologic Oncology 99

      Pages: S177-S186

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The nude rat as an orthotopic model for cervical cancer.2005

    • Author(s)
      Hamada, K., Ueda, N., Ito, M., Roth, J.A., Follen, M.
    • Journal Title

      Gynecologic Oncology 99

      Pages: S159-S165

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Immune response to repetitive adenovirus- mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide2005

    • Author(s)
      Hamada, K., Sakaue, M., Sarkar, A., Buchl, S., Satterfield, W., Keeling M., Sastry, J., Roth, J.A., Follen M.
    • Journal Title

      Gynecologic Oncology 99

      Pages: S177-S186

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A repliation-selective adenoviral vector for head and neck cancers.2005

    • Author(s)
      Tanaka, H., Shirakawa, T., Zhang, Z., Hamada, K., Gotoh, A., Nibu, K.
    • Journal Title

      Arch Otolaryngol Head Neck Surg 131

      Pages: 630-634

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 卵巣癌に対する遺伝子治療2005

    • Author(s)
      濱田雄行
    • Journal Title

      日本臨床 63(12)

      Pages: 552-561

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The nude rat as an orthotopic model for cervical cancer.2005

    • Author(s)
      Hamada, K., Ueda, N., Ito, M., Roth, J A Follen, M.
    • Journal Title

      Gynecologic Oncology 99

      Pages: S159-S165

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A replication-selective adenoviral vector for head and neck cancers.2005

    • Author(s)
      Tanaka, H., Shirakawa, T.Zhang, Z., Hamada, K., Gotoh, A., Nibu, K.
    • Journal Title

      Arch Otolaryngol Head Neck Surg 131

      Pages: 630-634

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene therapy for ovarian cancer.2005

    • Author(s)
      Hamada, K.
    • Journal Title

      Nihon Rinshou 63(12)

      Pages: 552-561

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Carrier cell-mediated infection of a replication-competent adenovirus for cancer gene therapy

    • Author(s)
      Hamada, K., Desaki, J., Nakagawa, K., Shirakawa, T., Gotoh, A., Tagawa, M.
    • Journal Title

      Molecular Therapy (In print)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Carrier cell-mediated infection of a replication-competent adenovirus for cancer gene therapy

    • Author(s)
      Hamada, K., Desaki, J., Nakagawa, K., Shirakawa, T., Gotoh, A., Tagawa, M.
    • Journal Title

      Molecular Therapy (in print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 7薬物治療、12)遺伝子治療、よくわかる卵巣癌のすベて2007

    • Author(s)
      濱田雄行
    • Total Pages
      8
    • Publisher
      永井書店
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

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