2006 Fiscal Year Final Research Report Summary
Analyses of vestibular cortical responses with Dipole-tracing method and functional near infrared
| Project/Area Number |
17591779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Toyama |
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Principal Investigator |
WATANABE Yukio University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Professor, 医学部, 教授 (10108037)
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| Co-Investigator(Kenkyū-buntansha) |
SHOJAKU Hideo University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Associate Professor (60187507)
UMENO Katsumi University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Instructor (90086596)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Dipole-tracing method / functional near infrared spectroscopy / vestibular stimulation / higher cortical function |
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| Research Abstract |
A system to evaluate functional localization in the brain corresponding to the vestibular stimulation was developed. In this system, a electro-encephalogram (EEG) and a functional near infrared spectroscopy (fNIRS) were simultaneously recorded and analyzed during vertigo elicited by the vestibular stimulations, which were made by the cold and hot air.
Two characteristic responses of blood flow, evaluated by the oxidized hemoglobin, were observed after the cold and warm caloric stimulation for two to four minutes. One was simple increase of the blood flow, observed in the parietal and temporal area of the brain, the other was two phase response of the blood flow in the frontal area, in which at first the blood flow decreased just after the vestibular stimulation and then it increased when the test subject felt vertigo.
These remarkable blood flow responses were observed in very wide area in the brain, such as precentral gyrus, frontoparietal operculum, frontal pole, postcentral gyrus, supramarginal gyrus, superior parietal lobule and superior temporal gyrus, the localization of which almost corresponded to those of the previous reports evaluated by other methods.
The EEG responses during the vestibular stimulation indicated a burst of θ-wave and increase of the power spectrum corresponding to the θ-wave by the frequency analysis, which might suggest that the increase of brain activity according to the vertigo elicited by the vestibular stimulation.
These results indicated that the simultaneous recording of the fNIRS and EEG could detect the activity of the cerebral cortex according to the vertigo and that our method could provide very useful clinical information for diagnosis and treatment of the peripheral vertiginous diseases.
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