2006 Fiscal Year Final Research Report Summary
Control of intraocular neovascularization by vitreous remodeling
| Project/Area Number |
17591820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Yamagata University |
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Principal Investigator |
TAKAHASHI Yoshinori Yamagata university, department of medicine, Lecturer, 医学部, 講師 (20236334)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Hidetoshi Yamagata university, department of medicine, Professor, 医学部, 教授 (90158163)
KANNO Makoto Yamagata university, department of medicine, Assistant Professor, 医学部, 助手 (80292415)
KAMIO Satomi Yamagata university, department of medicine, Assistant Professor, 医学部, 助手 (80375336)
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| Project Period (FY) |
2005 – 2006
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| Keywords | remodeling / hyalocyte / extracellular matrix |
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| Research Abstract |
Hyalocyte is concerned with vitreous remodeling by producing extracellular matrix (ECM). So we suppose hyalocyte plays an important role in vitreo-retinal disorders. To prove our hypothesis, we have established new cell-line of hyalocyte from pig vitreous.
The concentration of cytokines in the vitreous is changed in various disorders such as diabetic retinopathy, proliferative vitreo retinopathy. This change affects for hyalocyte. So we have examined the change of ECM production by stimulating various cytokines. Also we have studied about regulation of ECM production by adding steroid.
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