2007 Fiscal Year Final Research Report Summary
Development of evaluation methods for pathophysiology of ocular visual and motor system using current imaging technique and eye movement recording system
| Project/Area Number |
17591824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Niigata University |
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Principal Investigator |
TAKAGI Mineo Niigata University, Medical and Dental Hospital, Lecturer (60251807)
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| Project Period (FY) |
2005 – 2007
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| Keywords | magnetic resonance imaging / optic nerve complex / optic nerve diseases / eye movement recording system / pupil measurement / ocular torsion / near reflex / wave form of nystagmus |
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| Research Abstract |
Recently available three-dimensional fast imaging employing steady-state acquisition (3-D FIESTA) has provided excellent tissue contrast between the brain, nerve and cerebrospinal fluid, in addition to exhibiting high spatial resolution. We tested FIESTA in various optic nerve diseases in order to examine characteristic changes in the intraorbital optic nerve complex. Images of the acute phase of optic neuritis showed swelling of the optic nerve with reactive subarachnoidal space enlargement. In the optic perineuritis, the optic nerve diameter was normal but with surrounding inflammation. Images of optic atrophy including glaucoma showed subarachnoidal space enlargement with normal optic sheath circumference and a thinner optic nerve, while segmental optic nerve hypoplasia appeared with a smaller optic nerve sheath circumference without subarachnoidal space enlargement. The FIESTA sequence seemed to be a useful technique to differentiate optic neuropathies through the visualization of detailed structures of the optic nerve complex on coronal images of the orbit. Next, for eye movement and pupil research, we used video-image analysis system, Subjects' or patients' each eye was photographed with an infra-red CCD camera and recorded on a digital tape. The pupillary area, the center of the pupil, and the pattern of the iris were detected using a computer-assisted procedure, from which horizontal and vertical eye movements, pupillary response, and ocular torsion was calculated. The recorded papillary near reflex and ocular torsion during near response in various conditions. This system is also useful for clinical recording of nystagmus, tonic papillary response in Adie syndrome, convergence palsy and spasm, and characteristic aspects of vergence and pupil abnormalities were found.
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[Journal Article] Effect of the background on the disparity-induced ramp vergence response in humans2006
Author(s)
Hayakawa,Y., Takagi, M., Iijima, A. Bando, T., Takada, R., Miki, A. Usui, T., Hasegawa, S, Abe, H
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Journal Title
Ophthalmologica 220
Pages: 94-100
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Pupillography of relative afferent pupillary defect contralateral to monocular mature cataract2006
Author(s)
Miki, A. Iijima, A. Takagi, M., Usui, T., Hasegawa, S., Abe, H., Bando, T
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Journal Title
Canadian Journal of Ophthalmology 41
Pages: 469-471
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis2006
Author(s)
Ueki, S., Fujii, Y., Matsuzawa, H., Takagi, M., Abe, H., Kwee, I, L., Nakada, T
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Journal Title
American Journal of Ophthalmology 142
Pages: 591-596
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Negative scotopic ERG and photopic ON response impairment in a patient with normal dark adaptation2006
Author(s)
Tanimoto, N., Usui, T., Ichibe, M., Kuze, M., Takagi, M., Hasegawa, S., Sato, M., Tanaka, K., Abe, H
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Journal Title
Documenta Ophthalmologica 113
Pages: 171-177
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Night blindness with depolarizing pattern of ON/OFF response; a case report.2005
Author(s)
Usui, T., Tanimoto, N., Ueki, S., Miki, A., Takagi, M., et. al.
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Journal Title
Documenta Ophthalmologica 111
Pages: 15-21
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Cone dysfunction with negative electroretinogram and ring scotoma; a case report.2005
Author(s)
Usui, T., Tanimoto, N., Ichibe, M., Takagi, M., Hasegawa, S., Abe, H
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Journal Title
Neuro-ophthalmology 27
Pages: 111-120
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Abnormal electroretinographic findings in a patient with negative scotopic electroretinogram and dark adaptation2005
Author(s)
Tanimoto, N., Usui, T., Ichibe, M., Takagi, M., Hasegawa, S., Abe, H., Sato, M., Tanaka, K
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Journal Title
Neuro-Ophthalmology 29
Pages: 1-7
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Near-infrared Spectroscopy of the Visual Cortex in Unilateral Optic Neuritis2005
Author(s)
Miki, A, Nakajima, T, Takagi, M, Usui, T, Abe, H, Liu, C-SJ, Liu, G.T
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Journal Title
American Journal of Ophthalmology 139
Pages: 353-356
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] PIII and derived P II analysis in a patient with retinal dysfunction with supernormal scotopic ERG. Documenta2005
Author(s)
Tanimoto, N., Usui, T., Ichibe, M., Takagi, M., Hasegawa, S., Abe, H
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Journal Title
Ophthalmologica 110
Pages: 219-226
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Night blindness with depolarizing pattern of ON/OFF response; a case report2005
Author(s)
Usui, T., Tanimoto, N., Ueki, S., Miki, A. Takagi, M., Hasegawa, S., Abe, H
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Journal Title
Documenta Ophthalmologica 111
Pages: 15-21
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Rod and cone a-waves in central vein occlusion2005
Author(s)
Tanimoto, N., Usui, T., Ichibe, M., Takagi, M., Hasegawa, S., Abe, H
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Journal Title
Japanese Journal of Ophthalmology 49
Pages: 402-410
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A case of osteopetrosis with acute optic neuropathy
Author(s)
Tsuchida, H., Takagi, M., Miki, A. Usui, T., Hasegawa, S., Abe, H
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Journal Title
Japanese Journal of Ophthalmology in press
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Pituitary adenoma manifesting as an isolated abducens palsy
Author(s)
Miki, A. Takagi, M., Usui, T., Abe, H., Yaoeda, Y., Tumanuma, I
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Journal Title
Neuro-ophthalmology in press
Description
「研究成果報告書概要(欧文)」より
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