• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2006 Fiscal Year Final Research Report Summary

Comprehensive and prompt basic science study for protecting retinal ganglion cell by combined system of cultured cell and individual animals and application for clinical approach

Research Project

Project/Area Number 17591827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KASHIWAGI Kenji  University of Yamanashi, University of Yamanashi Hospital, Assistant Professor, 医学部附属病院, 講師 (30194723)

Co-Investigator(Kenkyū-buntansha) KOGURE Satoshi  University of Yamanashi, University of Yamanashi Hospital, Assistant Professor, 医学部附属病院, 講師 (40234736)
MABUCHI Tadashi  University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Research Associate, 大学院医学工学総合研究部, 助手 (80150308)
MABUCHI Fumihiko  University of Yamanashi, Department of Research Interdisciplinary Graduate' School of Medicine and Engineering, Research Associate, 大学院医学工学総合研究部, 助手 (20322125)
MAEDA Shu-ichiro  University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院医学工学総合研究部, 教授 (10117244)
Project Period (FY) 2005 – 2006
KeywordsRetinal ganglion cell / Glaucoma / Animal disease model / culture model / transgenic model
Research Abstract

Ocular disease targeting retinal ganglion cell (RGC) loss, such as glaucoma that is secondary cause of acquired blindness in the world, may cause severe and irreversible visual dysfunction. Many kinds of treatment including clinical applied for other diseases are subject to be candidated treatment for this insult. In this particular investigation., we aimed to investigate the effectiveness of either candidated or unknown factors for rescuing RGC loss using prompt and accurate evaluation system for pursuing new clinical treatment. In results, we success to establish new evaluation system for RGC damage, and we investigate several new potential neuron-protective drugs such as latanoprost and iganijipine. We also revealed new aspects regarding mechanism of damage of retinal neuron such as regulating kinase 1 that plays a important role in apoptosis of RGC and success to develop new approach for neuron-protection. We also investigated single nucleotide polymorphisms in glaucoma in genes of OPA-1, apolipoprotein E, and Methylenetetrahydrofolate reductase gene. Furthermore, at present, we are working on revising new in vivo and in vitro disease models, preparing several types of transgenic animals with new evaluation system for them, and developing new animal disease models using primate for investigating RGC disturbance for conducting good platform of translational research system. Those of them are expected to contribute investigation for new aspects of disturbance mechanism of RGC and development of new therapy.

  • Research Products

    (15 results)

All 2007 2006 2005

All Journal Article (14 results) Book (1 results)

  • [Journal Article] The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma2007

    • Author(s)
      F.Mabuchi
    • Journal Title

      American journal of ophthalmology 143・1

      Pages: 125-130

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma2007

    • Author(s)
      F.Mabuchi et al.
    • Journal Title

      American journal of ophthalmology 143(1)

      Pages: 125-130

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma2006

    • Author(s)
      F.Mabuchi
    • Journal Title

      Molecular Vision 7・12

      Pages: 735-739

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effect of unoprostone isopropyl on Ca2+ release - Activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells2006

    • Author(s)
      M.Shimura
    • Journal Title

      Journal of ocular pharmacology and therapeutics 22・4

      Pages: 219-226

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Neuroprotective effect of latanoprost on rat retinal ganglion cells2006

    • Author(s)
      H.Kudo
    • Journal Title

      Graefs Arch Clin Exp Ophthalmol 244・8

      Pages: 1003-1006

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of apoptosis signal - regulating kinase 1 in stress - induced neural cell apoptosis in vivo2006

    • Author(s)
      C.Harada
    • Journal Title

      American Journal of Pathology 168・1

      Pages: 261-269

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298AJC are not associated with open angle glaucoma2006

    • Author(s)
      F.Mabuchi
    • Journal Title

      Molecular Vision 7(12)

      Pages: 735-739

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of unoprostone isopropyl on Ca2+ release-Activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells2006

    • Author(s)
      M.Shimura
    • Journal Title

      Journal of ocular pharmacology and therapeutics 22(4)

      Pages: 219-226

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Neuroprotective effect of latanoprost on rat retinal ganglion cells2006

    • Author(s)
      H.Kudo
    • Journal Title

      Graefs Arch Clin Exp Ophthalmol 244(8)

      Pages: 1003-1006

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo2006

    • Author(s)
      C.Harada
    • Journal Title

      American journal of ophthalmology 168(1)

      Pages: 261-269

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population2005

    • Author(s)
      F.Mabuchi
    • Journal Title

      Molecular Vision 12・11

      Pages: 609-612

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ocular distribution after topical instillation and potential neuroprotective effect after intravitreal injection of the calcium channel blocker iganipidine2005

    • Author(s)
      M.Ohashi
    • Journal Title

      Current Eye Research 30・4

      Pages: 309-317

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population2005

    • Author(s)
      F.Mabuchi et al.
    • Journal Title

      Molecular Vision 12(11)

      Pages: 609.612

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ocular distribution after topical instillation and potential neuroprotective effect after intravitreal injection of the calcium channel blocker iganipidine2005

    • Author(s)
      M.Ohashi
    • Journal Title

      Current Eye Research 30(4)

      Pages: 309-317

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] あたらしい眼科2005

    • Author(s)
      柏木 賢治
    • Total Pages
      168-171
    • Publisher
      V 治療 1)薬物療法 神経保護と神経再生
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi