2007 Fiscal Year Final Research Report Summary
Development of new glaucoma drugs wing experimental glaucoma models and clinical study on pertinence of modem glaucoma management
| Project/Area Number |
17591828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu University |
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Principal Investigator |
YAMAMOTO Tetsuya Gifu University, Graduate School of Medicine, Professor (50134581)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Kazuhide Gifu University, Graduate School of Medicine, Associate professor (40234067)
AOYAMA Yumiko Gifu University, Hospital, Lecturer (00222498)
SAWADA Akira Gifu University, Hospital, Assistant professor (80293570)
ISHIDA Kyoko Gifu University, Hospital, Assistant professor (80334936)
SUEMORI Shinsuke Gifu University, Hospital, Assistant professor (80377663)
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| Project Period (FY) |
2005 – 2007
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| Keywords | glaucoma / normal-tension glaucoma / neuroprotection / intraocular pressure / opticnerve / experimental glaucoma |
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| Research Abstract |
Basic research
1. A new calpain inhibitor was Lund to have neuroprotective effect against NMDA-induced retinal ganglion cell damage.
2. Several commercial anti-glaucoma drugs have anti-proliferative effect on cultured human conjunctival cells.
3. Lomerizine, a calcium-channel blocker, was found. To have neuroprotective effect against retinal ganglion cell damage in a mouse model.
4. Metallothionein also has neuroprotective effect against NMDA-induced retinal ganglion cell damage in a mouse model.
5. Cobalt may induce selective loss of photoreceptor cells in mice.
6. The role of tissue type plasminogen activator was investigated in relation with apoptosis of retina and optic nerve.
Clinical research
1. Prognosis of primary angle-closure/primary angle-closure glaucoma was analyzed. It was found that PAS extent and presence of GON were closely correlated with the poor prognosis.
2. Anew method to analyze glaucomatous optic nerve pathology was established using a new stereo-fundus camera.
3. Asymmetry of the second kernel response measured by multifocal ERG between nasal and temporal regions was found to be related with the degree of visual field deterioration in normal-tension glaucoma.
4. It was Lund that sufficient IOP reduction significantly reduced the development of optic disc hemorrhages in both primary open-angle glaucoma and normal-tension glaucoma.
5. We established basic data of 24-hr variation of IOP in normal-tension glaucoma.
6. A population-based study found that the prevalence of total glaucoma was 5.0% and that of PACG to be 0.6% in Japanese aged 40 or older.
7. Basic data on optic disc topography measured by Heidelberg Retina Tomograph were established in Japanese.
8. An analysis on IOP reduction and aqueous outflow did not reveal definite relationship between IOP reduction by latanoprost and pretreatment tonographic C-value.
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[Journal Article] Three-dimensional reconstruction of optic nerve head from stereo fundus images and its quantitative estimation2007
Author(s)
Nakagawa, T., Hayashi, Y., Hatanaka, Y., Aoyama, A., Hara, T., Fujita, A., Kakogawa, M., Fujita, H., Yamamoto, T
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Journal Title
Proceedings of the 29th Annual International Conference of the IEEE EMBS
Pages: 6747-6750
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma2007
Author(s)
Asano, E., Mochizuki, K., Sawada, A., Nagasaka, E., Kondo, Y., Yamamoto, T
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Journal Title
Jpn J Ophthalmol 51(5)
Pages: 379-389
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The incidence of disc hemorrhage in open-angle glaucoma before and after trabeculectomy2006
Author(s)
Miyake, T., Sawada, A., Yamamoto, T., Miyake, K., Sugiyama, K., Kitazawa, Y
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Journal Title
J Glaucoma 15(2)
Pages: 164-171
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina2006
Author(s)
Hara, A., Niwa, M., Kumada, M., Aoki, H., Kunisada, T., Oyama, T., Yamamoto, T., Kozawa, O., Mori, H
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Journal Title
Brain Res 1085
Pages: 33-42
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat2006
Author(s)
Karim, MZ, Sawada, A., Kawakami, H., Yamamoto, T., Taniguchi, T
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Journal Title
Curr Eye Res 31
Pages: 273-283
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice2006
Author(s)
Suemori, 5., Shimazawa, M., Kawase, K., Satoh, M., Nagase, H., Yamamoto, T., Hara, H
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Journal Title
Invest Ophthalmol Vis Sci 47(9)
Pages: 3975-3982
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride2006
Author(s)
Hara, A., Niwa, M., Aoki, H., Kumada, M., Aoki, H., Kunisada, T., Oyama, T., Yamamoto, T., Kozawa, O., Mori, H
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Journal Title
Brain Res 1109(1)
Pages: 192-200
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade2005
Author(s)
Kumada, M., Niwa, M., Hara, A., Matsuno, H., Mod, H., Matsuo, O., Ueshima, S., Matsuo, O., Yamamoto, T., Kozawa, O
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Journal Title
Invest Ophthalmol Vis Sci 46(4)
Pages: 1504-1507
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The Tajimi Study Group, Japan Glaucoma Society : The Tajimi Study Report 2. Prevalence of primary angle closure and secondary glaucoma in a Japanese population2005
Author(s)
Yamamoto, T., Iwase, A., Araie, M., Suzuki, Y., Abe, H., Shirato, S., Kuwayama, Y., Mishima, HK., Shimizu, H., Tomita, G., Inoue, Y., Kitazawa, Y
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Journal Title
Ophthalmology 112(10)
Pages: 1661-1669
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] the HRT Study Group : Topographic characteristics of the optic nerve head measured with scanning laser tomography in normal Japanese subjects2005
Author(s)
Uchida, H., Yamamoto, T., Araie, M., Tomita, G., Shirakashi, M., Yoshikawa, K
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Journal Title
Jpn J Ophthalmol 49(6)
Pages: 469-476
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Detection of retinal nerve fiber layer defects in retinal fundus images using Gabor filtering2007
Author(s)
Hayashi, Y., Nakagawa, T., Hatanaka, Y., Aoyama, A., Kakogawa, M., Hara, T., Fujita, H., Yamamoto, T
Organizer
International Society for Optical Engineering 2007, poster presentation
Place of Presentation
San Diego, USA
Year and Date
20070217-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Cup region extraction of optic nerve head for three-dimensional retinal fundus image2007
Author(s)
Nakagawa, T., Hayashi, Y., Hatanaka, Y., Aoyama, A., Hara, T., Kakogawa, M., Fujita, H., Yamamoto, T
Organizer
Asian Forum on Medical Imaging 2007
Place of Presentation
Cheju, Korea
Year and Date
20070126-27
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Extraction of nerve fiber layer defects in ocular fundus images2006
Author(s)
Hayashi, Y., Nakagawa, T., Aoyama, A., Hara, T., Fujita, H., Yamamoto, T., Hatanaka, Y., Mizukusa, Y., Fujita, A., Kakogawa, M
Organizer
The 20th International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS2006) poster presentation
Place of Presentation
Osaka, Japan
Year and Date
20060628-0701
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma2005
Author(s)
Yamamoto, T., Hasegawa, K., Sawada, A., Ishida, K., Kawase, K
Organizer
World Glaucoma Congress poster presentation
Place of Presentation
Vienna, Austria
Year and Date
20050706-09
Description
「研究成果報告書概要(欧文)」より
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