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2007 Fiscal Year Final Research Report Summary

Evaluation of prospective clinical research on aptitude for photocoagulation therapy of diabetic retinopathy

Research Project

Project/Area Number 17591856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionTokyo Women's Medical University

Principal Investigator

HORI Sadao  Tokyo Women's Medical University, School of Medicine, Professor (20143498)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Naoto  Tokyo Women's Medical University, School of Medicine, Professor (80119031)
Project Period (FY) 2005 – 2007
Keywordsdiabetic retinopathy / photocoagulation / randomized clinical trial
Research Abstract

To evaluate the efficacy of timing and method of photocoagulation for pre-proliferative diabetic retinopathy, treated group and non-treated group were compared at 36 months after randomized prospective clinical trial.
Forty nine eyes were involved in the study with moderately severe pre-proliferative diabetic retinopathy and randomly divided into two groups; 23 eyes for treated group and 26 for non-treated, the eyes followed more than 36 months were 12 in the treated eyes and 20 in the non-treated eyes. In the treated group, selective photocoagulation was performed at the beginning of the trial to the non-perfused areas detected by fluorescein angiography (FAG). Additional coagulation was performed when the non-perfused area was progressed and detected at periodical examinations after the selective coagulation. In the non-treated group, scattered coagulation was performed when the neovascularization (NV) was detected by FAG at every 6-months examination.
At 36 months, 2 eyes developed NV in the treated group whereas 12 eyes in the non-treated group (p=0.02). When the visual acuity was compared between the baseline and at 36months, it reduced more than 2 lines in the treated group (p=0.047) and no reduction of visual acuity was noted in the non-treated group.
The photocoagulation was recommended for the moderately severe pre-proliferative diabetic retinopathy to prevent progression of proliferative diabetic retinopathy.

  • Research Products

    (4 results)

All 2009 2006

All Journal Article (4 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Association of vitreous inflammatory factors with diabetic macular edema.2009

    • Author(s)
      Funatsu H, Noma H, Mimura T, Eguchi S, Hori S
    • Journal Title

      Ophthalmology 116

      Pages: 73-79

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of perioperative glycemic control in progression of diabetic reti nopathy and maculopathy2006

    • Author(s)
      Suto C, Hori S, Kato S, Muraoka K, Kitano S
    • Journal Title

      Arch Ophthalmol 124

      Pages: 38-45

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Relationship between macular microcirculation and progression of diabetic macular edema2006

    • Author(s)
      Sakata K, Funatsu H, Harino S, Noma H, Hori S
    • Journal Title

      Ophthalmology 113

      Pages: 1385-1391

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of perioperative glycemic control in progression of diabetic r etinopathy and maculopathy2006

    • Author(s)
      Suto C, Hori S, Kato S, Muraoka K, Kitano S
    • Journal Title

      Arch Ophthalmol 124

      Pages: 38-45

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-06-09  

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