2007 Fiscal Year Final Research Report Summary
Gut flora and synbiotics therapy in patients with severe SIRS
| Project/Area Number |
17591887
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SHIMIZU Kentaro Osaka University, Osaka University Hospital, Medical Doctor (60379203)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi Osaka University Graduate School of Medicine, 医学系研究科, Professor (90127241)
SHIMAZU Takeshi Kinki University Hospital, 医学部附属病院, Professor (50196474)
TANAKA Hiroshi Department of Emergency Medicine and Critical Care Medicine Juntendo University, Urayasu Hospital, Professor (90252676)
KUWAGATA Yasuyuki Osaka University Graduate School of Medicine, 医学系研究科, Associate Professor (50273678)
OGURA Hiroshi Osaka University Graduate School of Medicine, 医学系研究科, Associate Professor (70301265)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Keywords | Synbiotics / Systemic inflammatory response syndrome / gut / sepsis / short-chain fatty acids / probiotics / prebiotics / flora |
|---|
| Research Abstract |
The gut is considered an important target organ of injury following severe insult such as sepsis, trauma, and shock. Synbiotics therapy is a combination with probiotics and prebiotics. We quantitatively evaluated changes in the gut microflora and environment in patients with severe SIRS, examined the effects of synbiotic treatment on clinical course, and evaluated the limitation of synbiotic treatment on gut dysmotility.
1) The gut flora and environment are significantly altered in patients with severe SIRS. Analysis of fecal flora confirmed that patients with severe SIRS showed significantly lower total anaerobic bacterial counts, in particular, 2-4 log units fewer beneficial Bifidobacterium and Lactobacillus and 2 log units more pathogenic Staphylococcus and Pseudomonas group counts than did healthy volunteers. Concentrations of total fecal organic acids, in particular, beneficial short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, were significantly decreas
… More
ed in the patients.
2) Synbiotics maintain the gut flora and environment in patients with severe SIRS and significantly reduce the incidence of septic complications. The incidences of infectious complications in patients with severe SIRS were significantly lower in the synbiotics group than in the control group(enteritis, 7%vs. 46%, pneumonia, 20% vs. 52%,and bacteremia, 10%vs. 33%, respectively). These beneficial effects of synbiotics in the present study may be due to improved gut flora, increased short-chain fatty acids.
3) In SIRS patients with synbiotic therapy(50cases), intestinal dymotility patients(5 cases) all had deterioration in their gut flora, caused bacteremia, and were mortal.
As a result, the deterioration of gut flora were related with septic complications and mortality. Synbiotics could maintain the gut flora and protect the critically ill patients from infectious complications. Further study is needed to clarify the mechanisms by which synbiotics decrease septic complications in patients with SIRS. Less
|
-
-
[Journal Article] Altered gut flora and environment in patients with severe SIRS2006
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Yoshiya K, Matsushima A, Sumi Y, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
-
Journal Title
J Trauma 60
Pages: 126-133
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] SIRS患者における腸内細菌叢、腸内環境の変化とシンバイオティクス療法の有効性(総説)2006
Author(s)
清水健太郎, 小倉裕司, 後藤美紀, 朝原崇, 野本康二, 諸富正己, 平出敦, 松嶋麻子, 田崎修, 鍬方安行, 田中裕, 嶋津岳士, 杉本壽
-
Journal Title
日本救急医学会雑誌 17
Pages: 833-844
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
[Journal Article] 侵襲に伴う腸内有機酸の変化2005
Author(s)
後藤美紀, 平出敦, 小倉裕司, 清水健太郎, 池側均, 鵜飼勲, 京力深穂, 杉本壽, 朝原崇, 野本康二, 諸富正己
-
Journal Title
栄養-評価と治療 22
Pages: 615-617
Description
「研究成果報告書概要(和文)」より
-
[Journal Article] Synbiotics decrease the incidence of septic complications in patients with severe SIRS : A preliminary report.
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Yoshiya K, Matsushima A, Sumi Y, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H.
-
Journal Title
Digestive Diseases and Sciences (印刷中)
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Synbiotics decrease the incidence of septic complications in patients with severe SIRS: A preliminary report.
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Yoshiya K, Matsushima A, Sumi Y, Kuwagala Y, Tanaka H, Shimazu T, Sugimoto H.
-
Journal Title
Digestive Diseases and Sciences (in press)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] Intestinal dysmotility and enteritis increase septic mortality in patients with severe SIRS.2007
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Tasaki O, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
Organizer
The 29^<th> ESPEN
Place of Presentation
Prague, Czech Republic
Year and Date
20070908-20070911
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
[Presentation] Altered gut flora and environment in severe SIRS : Are synbiotics viable treatment?2006
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Tasaki 0, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
Organizer
The 1^<st>international congress for medical use of functional foods
Place of Presentation
Tokyo, Japan
Year and Date
20061116-20061117
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] The persistent decrease of total obligate anaerobes in gut is related to the high mortality in patients with severe SIRS.(Emergency Medicine Specialty Award)2006
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Tasaki O, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
Organizer
The 36^<th> Critical Care Congress
Place of Presentation
Orland, U.S.A.
Year and Date
20060218-20060221
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] Synbiotics reduce the septic complications in patients with severe SIRS2006
Author(s)
Shimizu K. Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Tasaki O, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
Organizer
The 35^<th> Critical Care Congress
Place of Presentation
San Francisco, U.S.A.
Year and Date
20060106-20060111
Description
「研究成果報告書概要(欧文)」より
-
-
-
